Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Sandra L. Jimmo"'
1
Reduced Phosphodiesterase 3 Activity and Phosphodiesterase 3A Level in Synthetic Vascular Smooth Muscle Cells: Implications for Use of Phosphodiesterase 3 Inhibitors in Cardiovascular Tissues
Autor: Douglas G. Tilley, Donald H. Maurice, Sandra L. Jimmo, Daniel Palmer, Hanguan Liu, Heather A. Dunkerley
Publikováno v: Molecular Pharmacology. 61:1033-1040
Vascular smooth muscle cells (VSMC) in situ function to control contraction and are said to express a contractile phenotype. However, during development or in response to vascular damage, VSMC proliferate and express a more synthetic phenotype. A sur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52335653e9127043ffea530ce6437b2d
https://doi.org/10.1124/mol.61.5.1033
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2
Altered Phosphodiesterase 3-Mediated cAMP Hydrolysis Contributes to a Hypermotile Phenotype in Obese JCR:LA-cp Rat Aortic Vascular Smooth Muscle Cells
Autor: Douglas G. Tilley, Donald H. Maurice, P. Marlene Absher, Heather A. Dunkerley, Daniel R. Raymond, Robert B. Vernon, Stuart J. Netherton, Daniel Palmer, Sandra L. Jimmo, E. Helene Sage, James C. Russell
Publikováno v: Diabetes. 51:1194-1200
Cardiovascular diseases represent a significant cause of morbidity and mortality in diabetes. Of the many animal models used in the study of non-insulin-dependent (type 2) diabetes, the JCR:LA-cp rat is unique in that it develops insulin resistance i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf03f37af5cd07a10ed945b9d8a6b080
https://doi.org/10.2337/diabetes.51.4.1194
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3
Expression of Phosphodiesterase 4D (PDE4D) Is Regulated by Both the Cyclic AMP-dependent Protein Kinase and Mitogen-activated Protein Kinase Signaling Pathways
Autor: Donald H. Maurice, Douglas G. Tilley, Hanguan Liu, Stephen C. Pang, Heather A. Dunkerley, Sandra L. Jimmo, Daniel Palmer
Publikováno v: Journal of Biological Chemistry. 275:26615-26624
Multiple families of cyclic nucleotide phosphodiesterases (PDE) have been described, and the regulated expression of these genes in cells is complex. Although cAMP is known to control the expression of certain PDE in cells, presumably reflecting a sy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e852aabc78810728b923bb9bfefd32cd
https://doi.org/10.1074/jbc.m001634200
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5
Protein kinase A phosphorylation of human phosphodiesterase 3B promotes 14-3-3 protein binding and inhibits phosphatase-catalyzed inactivation
Autor: Daniel Palmer, Sandra L. Jimmo, Donald H. Maurice, Lindsay S. Wilson, Rhonda L. Carter, Daniel R. Raymond
Publikováno v: The Journal of biological chemistry. 282(13)
Recent studies confirm that intracellular cAMP concentrations are nonuniform and that localized subcellular cAMP hydrolysis by cyclic nucleotide phosphodiesterases (PDEs) is important in maintaining these cAMP compartments. Human phosphodiesterase 3B
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306dfd3ea0a1aae75f93515ceb1ccd9e
https://pubmed.ncbi.nlm.nih.gov/17255105
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6
Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system
Autor: Donald H. Maurice, Stuart J. Netherton, Douglas G. Tilley, Heather A. Dunkerley, Sandra L. Jimmo, Hisham S. Elbatarny, Daniel Palmer, Daniel R. Raymond
Publikováno v: Molecular pharmacology. 64(3)
Cyclic AMP (cAMP) and cGMP regulate a myriad of cellular functions, such as metabolism, contractility, motility, and transcription in virtually all cell types, including those of the cardiovascular system. Considerable effort over the last 20 years h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06dff8bf3715869067b7004c350e90f
https://pubmed.ncbi.nlm.nih.gov/12920188
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8
Zinc alters conformation and inhibits biological activities of nerve growth factor and related neurotrophins
Autor: Sandra L. Jimmo, Donald F. Weaver, Suzanne M. Dostaler, Richard J. Riopelle, Mark Solc, Igor L. Shamovsky, Gail Lawrance, Gregory M. Ross
Publikováno v: Nature medicine. 3(8)
A role for Zn2+ in a variety of neurological conditions such as stroke, epilepsy and Alzheimer's disease has been postulated. In many instances, susceptible neurons are located in regions rich in Zn2+ where nerve growth factor (NGF) levels rise as a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2994b8a87fe2c8c0498fcbc0a93c47e
https://pubmed.ncbi.nlm.nih.gov/9256278
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