Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sandra L. Cockerham"'
Autor:
Guoqing Cao, Thomas P. Beyer, Youyan Zhang, Robert J. Schmidt, Yan Q. Chen, Sandra L. Cockerham, Karen M. Zimmerman, Sotirios K. Karathanasis, Ellen A. Cannady, Todd Fields, Nathan B. Mantlo
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 12, Pp 2169-2176 (2011)
Cholesteryl ester transfer protein (CETP) catalyses the exchange of cholesteryl ester and triglyceride between HDL and apoB containing lipoprotein particles. The role of CETP in modulating plasma HDL cholesterol levels in humans is well established a
Externí odkaz:
https://doaj.org/article/814d7db5161b4c7e8b11650ddcf3aa93
Autor:
Sandra L. Cockerham, Anthony G. Borel, Eva Maria Martin De La Nava, Daniel Ray Mayhugh, Sweetana Stephanie Ann, Nathan Bryan Mantlo, Youyan Zhang, Timothy M. Jones, Robert J. Schmidt, Thomas P. Beyer, Ellen A. Cannady, Ana Maria Escribano, Ana I. Mateo, Guoqing Cao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3671-3675
This letter describes the discovery and SAR optimization of tetrazoyl tetrahydroquinoline derivatives as potent CETP inhibitors. Compound 6m exhibited robust HDL-c increase in hCETP/hApoA1 double transgenic model and favorable pharmacokinetic propert
Autor:
Nathan Bryan Mantlo, Youyan Zhang, Eva Maria Martin De La Nava, Thomas P. Beyer, Gregory A. Stephenson, Saravanan Parthasarathy, Anthony G. Borel, Sandra L. Cockerham, Xiaodong Wang, Sweetana Stephanie Ann, Maria-Carmen Fernandez, Ana I. Mateo, Robert J. Schmidt, Ana Maria Escribano, Timothy M. Jones, Scott Alan Frank, Guoqing Cao, Ellen A. Cannady
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3056-3062
This Letter describes the discovery and SAR optimization of 1,5-tetrahydronaphthyridines, a new class of potent CETP inhibitors. The effort led to the identification of 21b and 21d with in vitro human plasma CETP inhibitory activity in the nanomolar
Autor:
Jason Scott Sawyer, Michael J. Sofia, Peter W. Stengel, Steven A. Silbaugh, Stephen M. Spaethe, Sandra L. Cockerham, Alison M. Bendele, William T. Jackson, Larry L. Froelich
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 361:397-404
We examined the in vivo actions of LY293111 sodium (2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]pro poxy]phenoxy] benzoic acid sodium salt). Guinea pigs were used to evaluate the effect of this agent on (1) acute airway obstruction
Publikováno v:
European Journal of Pharmacology. 557:66-68
In guinea pigs, we found that intravenous 5,8,11,14-eicosatetraenamide ( N -2-hydroxyethyl), arachidonylethanolamide (anandamide), 0.3–10.0 mg/kg, did not inhibit leukotriene D 4 (LTD 4 )-induced airway obstruction, while inhaled anandamide, 21.8 a
Autor:
Steven A. Silbaugh, William A. Devane, Sandra L. Cockerham, Peter W. Stengel, Marian K. Rippy
Publikováno v:
European Journal of Pharmacology. 355:57-66
Anandamide (arachidonylethanolamide), 5,8,11,14-eicosatetraenamide, ( N -2-hydroxyethyl), was tested for bronchodilator and anti-inflammatory activities. Conscious guinea pigs were given cumulative i.v. doses of anandamide (1.0, 3.0, and 10.0 mg/kg)
Autor:
J. Scott Sawyer, Sandra L. Cockerham, K. Jeff Thrasher, Larry L. Froelich, Carlos R. Roman, Bach Nicholas J, Peter W. Stengel, Jerome H. Fleisch, Steven A. Silbaugh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:249-252
A series of quinoline-substituted dihydroindoles has been synthesized and evaluated as antagonists of the cysLT 1 receptor. This series, exemplified by 2 (LY302905; pKi = 8.3 for inhibition of binding of 3 H-LTD 4 to guinea pig lung membranes), repre
Publikováno v:
Respiration Physiology. 102:97-104
We exposed conscious A/J mice to several challenge aerosols and measured gas trapped within excised lungs by quantitating their buoyancy in saline (Archimedes' principle). The temporal stability of the excised lung gas volume (ELGV) measurement was a
Publikováno v:
Neuropeptides. 28:35-42
We examined the relationship between airway obstruction and plasma extravasation produced by the intravenous administration of the selective NK1 receptor agonist [Sar9, Met(O2)11]-substance P(SP). Conscious guinea-pigs were injected with Evans' blue
Publikováno v:
European Journal of Pharmacology. 253:253-259
We examined the effect of dexamethasone on A23187-induced bronchospasm, pulmonary inflammation and airway responses to substance P. Guinea pigs, dosed orally once a day for 4 days with dexamethasone (3.0, 10.0 or 30.0 mg/kg) or saline, were exposed t