Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models

Autor: Morteza Chalabi Hajkarim, Ella Karjalainen, Mikhail Osipovitch, Konstantinos Dimopoulos, Sandra L Gordon, Francesca Ambri, Kasper Dindler Rasmussen, Kirsten Grønbæk, Kristian Helin, Krister Wennerberg, Kyoung-Jae Won

Publikováno v: eLife, Vol 11 (2022)

Large-scale multiparameter screening has become increasingly feasible and straightforward to perform thanks to developments in technologies such as high-content microscopy and high-throughput flow cytometry. The automated toolkits for analyzing simil

Externí odkaz: https://doaj.org/article/3f675683279247e3902e4a69cb12b59a

Dissecting the impact of environment, season and genotype on blackcurrant fruit quality traits

Autor: Delphine M. Pott, Sara Durán-Soria, J. William Allwood, Simon Pont, Sandra L. Gordon, Nikki Jennings, Ceri Austin, Derek Stewart, Rex M. Brennan, Agnieszka Masny, Anita Sønsteby, Erika Krüger, Dorota Jarret, José G. Vallarino, Björn Usadel, Sonia Osorio

Publikováno v: Food Chemistry
Food chemistry 402, 134360-(2023). doi:10.1016/j.foodchem.2022.134360

This work aims to determine the effect of genotype x environment (GxE) interaction that influence blackcurrant (Ribes nigrum) fruit quality. We applied metabolomics-driven analysis on fruits from four cultivars grown in contrasting European-locations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1169bf42770c87a8d63ea6ef2fa88f3
https://hdl.handle.net/11250/3061853

Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models

Autor: Ella Karjalainen, Morteza Chalabi Hajkarim, Mikhail Osipovitch, Konstantinos Dimopoulos, Sandra L Gordon, Francesca Ambri, Kasper Dindler Rasmussen, Kirsten Grønbæk, Kristian Helin, Krister Wennerberg, Kyoung-Jae Won

Publikováno v: Chalabi Hajkarim, M, Karjalainen, E, Osipovitch, M, Dimopoulos, K, Gordon, S L, Ambri, F, Rasmussen, K D, Grønbæk, K, Helin, K, Wennerberg, K & Won, K-J 2022, ' Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models ', eLife, vol. 11, e73760 . https://doi.org/10.7554/eLife.73760

Large-scale multiparameter screening has become increasingly feasible and straightforward to perform thanks to developments in technologies such as high-content microscopy and high-throughput flow cytometry. The automated toolkits for analyzing simil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7a199d9f50566a99a89ca2b875725a
https://curis.ku.dk/portal/da/publications/comprehensive-and-unbiased-multiparameter-highthroughput-screening-by-compare-finds-effective-and-subtle-drug-responses-in-aml-models(e0f96da2-3ced-4480-acad-eabd0e85cb66).html

NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals

Autor: Malcolm V. Gee, Hideo Kon, Sandra L. Gordon, Nicholas R. Bachur

Publikováno v: Proceedings of the National Academy of Sciences. 76:954-957

With NADPH as the electron donor, rat liver NADPH cytochrome P-450 reductase (NADPH:ferricytochrome oxidoreductase, EC 1.6.2.4) catalyzes the single-electron reduction of several quinone antibiotics to a semiquinone or free radical state. The benzant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655a57bf8121b4d0272bf342254f4586
https://doi.org/10.1073/pnas.76.2.954