Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Sandra L, Grimm"'
Autor:
Ashok Subedi, Asieh Etemad, Aadhya Tiwari, Yuying Huang, Biji Chatterjee, Samantha M. McLeod, Yungang Lu, DiAngelo Gonzalez, Krishna Ghosh, Mario Sirito, Sanjay K. Singh, Elisa Ruiz, Sandra L. Grimm, Cristian Coarfa, Hui-Lin Pan, Sadhan Majumder
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The transcription repressor REST in the dorsal root ganglion (DRG) is upregulated by peripheral nerve injury and promotes the development of chronic pain. However, the genes targeted by REST in neuropathic pain development remain unclear. Th
Externí odkaz:
https://doaj.org/article/96c8383e4d684ecbb3fc611ee169bb66
Autor:
Grace O. Adeniyi-Ipadeola, Julia D. Hankins, Amal Kambal, Xi-Lei Zeng, Ketki Patil, Victoria Poplaski, Carolyn Bomidi, Hoa Nguyen-Phuc, Sandra L. Grimm, Cristian Coarfa, Fabio Stossi, Sue E. Crawford, Sarah E. Blutt, Allison L. Speer, Mary K. Estes, Sasirekha Ramani
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Human intestinal enteroids (HIEs) are gaining recognition as physiologically relevant models of the intestinal epithelium. While HIEs from adults are used extensively in biomedical research, few studies have used HIEs from infants. Consideri
Externí odkaz:
https://doaj.org/article/21fddf0cda974e5890184c60894d739a
Autor:
Tajhal D. Patel, Sandra L. Grimm, Rupa S. Kanchi, Tanmay Gandhi, Amrit Koirala, Jason T. Yustein, Cristian Coarfa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Osteosarcoma is the most prevalent bone tumor in pediatric patients. Neoadjuvant chemotherapy has improved osteosarcoma patient survival, however the 5-year survival rate for localized osteosarcoma is 75% with a 30–50% recurrence rate. We,
Externí odkaz:
https://doaj.org/article/3d66ea6b725f45dba0ecec6c9390c625
Autor:
Sandra L. Grimm, Samuel Reddick, Xiaoyu Dong, Connor Leek, Amy Xiao Wang, Manuel Cantu Gutierrez, Sean M. Hartig, Bhagavatula Moorthy, Cristian Coarfa, Krithika Lingappan
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background Bronchopulmonary dysplasia (BPD) is characterized by an arrest in lung development and is a leading cause of morbidity in premature neonates. It has been well documented that BPD disproportionally affects males compared to females
Externí odkaz:
https://doaj.org/article/b08c6f1bdb5049889cfae7c8a2b0788f
Autor:
Jose Thaiparambil, Jianrong Dong, Sandra L. Grimm, Dimuthu Perera, Chandra Shekar R. Ambati, Vasanta Putluri, Matthew J. Robertson, Tajhal D. Patel, Brandon Mistretta, Preethi H. Gunaratne, Min P. Kim, Jason T. Yustein, Nagireddy Putluri, Cristian Coarfa, Randa El‐Zein
Publikováno v:
Cancer Medicine, Vol 12, Iss 1, Pp 584-596 (2023)
Abstract Background Non‐small cell lung cancer (NSCLC) comprises the majority (~85%) of all lung tumors, with lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) being the most frequently diagnosed histological subtypes. Multi‐modal omi
Externí odkaz:
https://doaj.org/article/446a9373295047ea962bd5f2c349b9b6
Autor:
Chathura J. Gunasekara, Harry MacKay, C. Anthony Scott, Shaobo Li, Eleonora Laritsky, Maria S. Baker, Sandra L. Grimm, Goo Jun, Yumei Li, Rui Chen, Joseph L. Wiemels, Cristian Coarfa, Robert A. Waterland
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background Genetic variants can modulate phenotypic outcomes via epigenetic intermediates, for example at methylation quantitative trait loci (mQTL). We present the first large-scale assessment of mQTL at human genomic regions selected for i
Externí odkaz:
https://doaj.org/article/d2673718183743649c5bae8c0315c583
Autor:
Sandra L. Grimm, Rachel E. Stading, Matthew J. Robertson, Tanmay Gandhi, Chenlian Fu, Weiwu Jiang, Guobin Xia, Krithika Lingappan, Cristian Coarfa, Bhagavatula Moorthy
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102790- (2023)
Oxygen supplementation is life saving for premature infants and for COVID-19 patients but can induce long-term pulmonary injury by triggering inflammation, with xenobiotic-metabolizing CYP enzymes playing a critical role. Murine studies showed that C
Externí odkaz:
https://doaj.org/article/dab80afae43644dcbeba12aeb3c31668
Autor:
Lourdes Chacon-Alberty, Rupa S. Kanchi, Shengbin Ye, Camila Hochman-Mendez, Daoud Daoud, Cristian Coarfa, Meng Li, Sandra L. Grimm, Maher Baz, Ivan Rosas, Gabriel Loor
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The clinical use of circulating biomarkers for primary graft dysfunction (PGD) after lung transplantation has been limited. In a prospective single-center cohort, we examined the use of plasma protein biomarkers as indicators of PGD severity
Externí odkaz:
https://doaj.org/article/99d48daca2db430cba08b34a3bbe7778
Autor:
Emily F. Mendez, Sandra L. Grimm, Laura Stertz, Damian Gorski, Sai V. Movva, Katherine Najera, Karla Moriel, Thomas D. Meyer, Gabriel R. Fries, Cristian Coarfa, Consuelo Walss-Bass
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
IntroductionHuman-derived induced pluripotent stem cell (iPSC) models of brain promise to advance our understanding of neurotoxic consequences of drug use. However, how well these models recapitulate the actual genomic landscape and cell function, as
Externí odkaz:
https://doaj.org/article/e69ef664aef746999f9747cf0a007401
Autor:
Tattym E. Shaiken, Sandra L. Grimm, Mohamad Siam, Amanda Williams, Abdol-Hossein Rezaeian, Daniel Kraushaar, Emily Ricco, Matthew J. Robertson, Cristian Coarfa, Antrix Jain, Anna Malovannaya, Fabio Stossi, Antone R. Opekun, Alyssa P. Price, Julien Dubrulle
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105965- (2023)
Summary: Despite the knowledge that protein translation and various metabolic reactions that create and sustain cellular life occur in the cytoplasm, the structural organization within the cytoplasm remains unclear. Recent models indicate that cytopl
Externí odkaz:
https://doaj.org/article/f9e71643635c4025b44b5b347560559c