Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Sandra Kleinau"'
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background The therapeutic IgG1 anti-CD20 antibody, rituximab (RTX), has greatly improved prognosis of many B-cell malignancies. Despite its success, resistance has been reported and detailed knowledge of RTX mechanisms are lacking. Compleme
Externí odkaz:
https://doaj.org/article/dbbbec6a1c43408eacd57d446e79377a
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3890 (2022)
Monocytes were previously thought to be the precursors of all tissue macrophages but have recently been found to represent a unique population of cells, distinct from the majority of tissue macrophages. Monocytes and intestinal macrophages seem now t
Externí odkaz:
https://doaj.org/article/6e8591e9245941379960503ceac50224
Autor:
Aida Paivandy, Srinivas Akula, Sandra Lara, Zhirong Fu, Anna-Karin Olsson, Sandra Kleinau, Gunnar Pejler, Lars Hellman
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1185 (2022)
To obtain a more detailed picture of macrophage (MΦ) biology, in the current study, we analyzed the transcriptome of mouse peritoneal MΦs by RNA-seq and PCR-based transcriptomics. The results show that peritoneal MΦs, based on mRNA content, under
Externí odkaz:
https://doaj.org/article/417f75df104c4331b2a8a7cd09307b6c
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137474 (2015)
Fc receptors (FcR) interacting with immune complexes (ICs) is a central event in the immune pathogenesis of rheumatoid arthritis (RA). Here we asked if a specific FcR is linked to RA pathogenesis and if FcR activities relate to disease and treatment
Externí odkaz:
https://doaj.org/article/911c8a4d9fe34c548d5c90ea9ea222c8
Background The therapeutic IgG1 anti-CD20 antibody, rituximab (RTX), has greatly improved prognosis of many B-cell malignancies. Despite its success, resistance has been reported and detailed knowledge of RTX mechanisms are lacking. Complement-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293bc47865f011c5122aec512fec9a8a
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-483791
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-483791
Monoclonal antibodies (mAbs) have revolutionized clinical medicine, especially in the field of cancer immunotherapy. The challenge now is to improve the response rates, as immunotherapy still fails for many patients. Strategies to enhance tumor cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4757725434d75b47f292e670e4a435d8
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445481
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445481
Monoclonal antibodies (mAb) have revolutionized clinical medicine, especially in the field of cancer immunotherapy. The challenge now is to improve the response rates in the patients, as immunotherapy still fails for many patients. Strategies to enha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79ea448068d8f5deffa54d1096347c7b
https://doi.org/10.1101/2020.07.01.181800
https://doi.org/10.1101/2020.07.01.181800
Autor:
Xochiquetzal J. Geiger, Wentian Luo, Linna Ge, Dorin-Bogdan Borza, Andrew Wasiluk, Laurence Heidet, Xu Ping Wang, Sandra Kleinau, A. Richard Kitching, Jeffrey H. Miner, Florina Olaru
Publikováno v:
The Journal of Immunology. 190:1424-1432
Goodpasture disease is an autoimmune kidney disease mediated by autoantibodies against noncollagenous domain 1 (NC1) monomers of α3(IV) collagen that bind to the glomerular basement membrane (GBM), usually causing rapidly progressive glomerulonephri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::722e70b9f09d4d9f9eb675186f570a14
https://doi.org/10.4049/jimmunol.1202204
https://doi.org/10.4049/jimmunol.1202204
A monoclonal antibody reactive with the mycobacterial 65 kDa heal shock protein (ML 30) was investigated for reactivity with biopsies from normal rat joints and with inflamed joints due to adjuvant arthritis (AA) or collagen induced arthrilis (CIA).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd61e806d2267fec3cd9d1ab19e2578
https://ora.ox.ac.uk/objects/uuid:bbac97e3-88a1-412e-b277-ded5ad3c0dc1
https://ora.ox.ac.uk/objects/uuid:bbac97e3-88a1-412e-b277-ded5ad3c0dc1
Publikováno v:
Scientific Reports
Marginal zone (MZ) B cells, representing a distinct subset of innate-like B cells, mount rapid T-independent responses to blood-borne antigens. They express low-affinity polyreactive antigen receptors that recognize both foreign and self-structures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25734a9cd697eec4a60590dbf27195c