Výsledky vyhledávání - "Sandra Keerthisinghe"

Akademický článek

Targeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides

Autor: Darryl M. Wilson, Daniel J. Driedger, Dennis Y. Liu, Sandra Keerthisinghe, Adrian Hermann, Christoph Bieniossek, Roger G. Linington, Robert A. Britton

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Polyketide or polyketide-like macrolides (pMLs) continue to serve as a source of inspiration for drug discovery. However, their inherent structural and stereochemical complexity challenges efforts to explore related regions of chemical space

Externí odkaz: https://doaj.org/article/ade8a36322684d49b417cc35ec35dfe3

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Microwave-irradiated rapid synthesis of antimicrobial pyrazine derivatives in reactive eutectic media

Autor: Helen Schneider, Nabyl Merbouh, Sandra Keerthisinghe, Markus Antonietti, Svitlana Filonenko

Publikováno v: Green Chemistry

Herein, we report of the use of reactive eutectic media from ammonium formate and monosaccharides to synthesize poly(hydroxyalkyl)pyrazines via microwave irradiation. This enabled unprecedented fast rates as well as better atom economy compared to pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedff889ba91e22954d97be2c3b9df22
https://doi.org/10.1039/d2gc03122a

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Total synthesis of biselide A

Autor: Darryl Wilson, F. P. Jake Haeckl, Sandra Keerthisinghe, Daniel Kwon, Roger G. Linington, Matthew Taron, Hope Fan, Venugopal Rao Challa, Robert Britton, Baldip Kang

Publikováno v: Chemical Science

A total synthesis of the marine macrolide biselide A is described that relies on an enantiomerically enriched α-chloroaldehyde as the sole chiral building block. Several strategies to construct the macrocycle are presented including a macrocyclic Re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba03d4499c019c5cb2bc3dba402b76b8
https://pubmed.ncbi.nlm.nih.gov/34168790

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The FOUR LIPS and MYB88 transcription factor genes are widely expressed in Arabidopsis thaliana during development

Autor: Xiaohong Wen, EunKyoung Lee, Lien Lai, Fred D. Sack, Sandra Keerthisinghe, Qin Lei, Meng Li, Xiaolin Ren, Jessica R. Lucas

Publikováno v: American Journal of Botany. 102:1521-1528

Premise of the study The FOUR LIPS (FLP) and MYB88 transcription factors, which are closely related in structure and function, control the development of stomata, as well as entry into megasporogenesis in Arabidopsis thaliana. However, other location

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678edbd72d444c9d959f98cbf7d78fff
https://doi.org/10.3732/ajb.1500056

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