Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Sandra K Weller"'
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003652 (2013)
Herpes Simplex Virus type 1 (HSV-1) has evolved to disable the cellular DNA damage response kinase, ATR. We have previously shown that HSV-1-infected cells are unable to phosphorylate the ATR substrate Chk1, even under conditions in which replication
Externí odkaz:
https://doaj.org/article/82ad8553ab924d2196e8260f79f0c6d1
Autor:
April J Schumacher, Kareem N Mohni, Yinan Kan, Eric A Hendrickson, Jeremy M Stark, Sandra K Weller
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002862 (2012)
Production of concatemeric DNA is an essential step during HSV infection, as the packaging machinery must recognize longer-than-unit-length concatemers; however, the mechanism by which they are formed is poorly understood. Although it has been propos
Externí odkaz:
https://doaj.org/article/751feac02ab846c08c4e260d54ba26af
Autor:
Sandra K Weller
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001105 (2010)
Externí odkaz:
https://doaj.org/article/e5b0a83581eb46aea8e4a2f26c323ced
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000619 (2009)
Virus-Induced Chaperone-Enriched (VICE) domains form adjacent to nuclear viral replication compartments (RC) during the early stages of HSV-1 infection. Between 2 and 3 hours post infection at a MOI of 10, host protein quality control machinery such
Externí odkaz:
https://doaj.org/article/0632de2c7dee4785848f141650c9d596
Autor:
Katherine A. DiScipio, Savithri Weerasooriya, Renata Szczepaniak, Akram Hazeen, Lee R. Wright, Dennis L. Wright, Sandra K. Weller
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT The majority of drug discovery efforts against herpesviruses have focused on nucleoside analogs that target viral DNA polymerases, agents that are associated with dose-limiting toxicity and/or a narrow spectrum of activity. We are pursuing a
Externí odkaz:
https://doaj.org/article/b11c066f7d064ddbbe256897f68ddac0
Publikováno v:
Viruses, Vol 14, Iss 7, p 1557 (2022)
In this review, we explore recombination in two very different virus families that have become major threats to human health. The Herpesviridae are a large family of pathogenic double-stranded DNA viruses involved in a range of diseases affecting bot
Externí odkaz:
https://doaj.org/article/ad62b345ad96424d80a35562271ac080
Autor:
Sandra K. Weller, Neal A. DeLuca
Publikováno v:
EMBO Rep
Herpes simplex virus (HSV) establishes latent infection in long-lived neurons. During initial infection, neurons are exposed to multiple inflammatory cytokines but the effects of immune signaling on the nature of HSV latency are unknown. We show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d33777b67311c9e8a7c33288694905d
https://doi.org/10.15252/embr.202153496
https://doi.org/10.15252/embr.202153496
Autor:
Kumar Singh Saikatendu, Michael J. Sofia, Matthew D. Disney, David Baker, Jennifer O. Nwankwo, Marla Weetall, Annaliesa S. Anderson, Christopher P. Austin, Mindy I. Davis, Matthias Götte, Emmie de Wit, Andrew D. Mesecar, Matthew D. Hall, Richard J. Whitley, Stephanie Moore, James M. Anderson, Kara Carter, George R. Painter, Anthony J. Conley, Charlotte A. Lanteri, Sandra K. Weller, Jay Bradner, Celia A. Schiffer, Tomas Cihlar, Abigail Grossman, Timothy P. Sheahan, Kizzmekia S. Corbett, Stephanie L. Ford-Scheimer, Kyle R. Brimacombe, Lillian Chiang, Elizabeth A. Campbell, Daria J. Hazuda, Mark R. Denison, Frederick G. Hayden, Sara Cherry, Pei Yong Shi, Courtney V. Fletcher, Hilary D. Marston, Jules O'Rear, Hugh D. C. Smyth, Francis S. Collins, Anthony S. Fauci
Publikováno v:
The Journal of Infectious Diseases
The NIH Virtual SARS-CoV-2 Antiviral Summit, held on 6 November 2020, was organized to provide an overview on the status and challenges in developing antiviral therapeutics for coronavirus disease 2019 (COVID-19), including combinations of antivirals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fbeec014e16d0c92ea9ed32a14e4019
Autor:
Thierry Douki, Jaliyah Peterson, Emily Camilleri, Willie Taylor, Peter Setlow, Ralf Moeller, Sandra K. Weller, D. Levi Craft, George Korza, Maria Rocha Granados, Wendy W. K. Mok, Renata Szczpaniak
Publikováno v:
Applied and Environmental Microbiology
Applied and Environmental Microbiology, American Society for Microbiology, 2020, 86 (8), ⟨10.1128/AEM.03039-19⟩
Applied and Environmental Microbiology, 2020, 86 (8), ⟨10.1128/AEM.03039-19⟩
Appl Environ Microbiol
Applied and Environmental Microbiology, American Society for Microbiology, 2020, 86 (8), ⟨10.1128/AEM.03039-19⟩
Applied and Environmental Microbiology, 2020, 86 (8), ⟨10.1128/AEM.03039-19⟩
Appl Environ Microbiol
This study examined the microbicidal activity of 222-nm UV radiation (UV(222)), which is potentially a safer alternative to the 254-nm UV radiation (UV(254)) that is often used for surface decontamination. Spores and/or growing and stationary-phase c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900a78a92727bc809ba6055499f559ff
https://hal.archives-ouvertes.fr/hal-02565567
https://hal.archives-ouvertes.fr/hal-02565567
Publikováno v:
Journal of Biological Chemistry. 292:15611-15621
During lytic infection, herpes simplex virus (HSV) DNA is replicated by a mechanism involving DNA recombination. For instance, replication of the HSV-1 genome produces X- and Y-branched structures, reminiscent of recombination intermediates. HSV-1's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1862f0d75d228dcba9624dc32aa884
https://doi.org/10.1074/jbc.m117.799064
https://doi.org/10.1074/jbc.m117.799064