The Step Test Evaluation of Performance on Stairs (STEPS): Validation and reliability in a neurological disorder.

Autor: Anne D Kloos, Deb A Kegelmeyer, Katherine Ambrogi, David Kline, Meredith McCormack-Mager, Brittany Schroeder, Sandra K Kostyk

Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0213698 (2019)

BackgroundIndividuals with neurological disorders often have difficulty negotiating stairs that can lead to injurious falls. Clinicians lack a clinical tool to identify impairments in stair negotiation and to assist their decision making regarding tr

Externí odkaz: https://doaj.org/article/c8baf643da9641598e190008c83c5903

Safety and efficacy of valbenazine for the treatment of chorea associated with Huntington's disease (KINECT-HD): a phase 3, randomised, double-blind, placebo-controlled trial

Autor: Erin Furr Stimming, Daniel O Claassen, Elise Kayson, Jody Goldstein, Raja Mehanna, Hui Zhang, Grace S Liang, Dietrich Haubenberger, Jamie Adams, Christopher Beck, Cheryl Chen, Martha Nance, Claudia Testa, Patricia Huffman, Amy Chesire, Frederick Marshall, Praveen Dayalu, Angela Stovall, Deborah Hall, Jacob Hawkins, Letty Ginsburg, Henry Moore, Tiago Mestre, Tanya Thompson, Natalie Connors, H. Diana Rosas, Allison Daley, Sandra K. Kostyk, Casey Mitchell, Amy Hellman, Sheryl Houston, Danielle Buchanan, Katherine McDonell, Stewart A. Factor, Elaine Sperin, Andrea Hurt, Joanne Wojcieszek, Mike Adurogbangba, Lynn A. Raymond, Jody Corey-Bloom, Chase Snell, Courtney Blair, Victor Sung, Sophia Antonioli, Jacqueline Fung, Simon Laganiere, Luis Sierra, William M. Mallonee, Greg Suter, Danny Bega, Zsa Zsa Brown, Lawrence Elmer, Nancy Vollmar, Debra del Castillo, Yi-Han Lin, Kelly Andrzejewski, Patricia Weigel, Trevor Hawkins, Kendra Kirby, Cimmaron Retzik-Stahr, Lauren Seeberger, Rohit Dhall, Anja Rassmann, McKenzie Luxmore, Burton Scott, James Boyd, Katherine Chan, Nikolaus McFarland, Kyle Rizer, Patricia Conlon, Valerie Suski, Federico Rodriguez-Porcel, Sandra Wilson, Christine Farrell, David Hunter, David Houghton, Sarah Seoane, Clare Gibbons, Philippe Rizek, Robin Kuprewicz, Steven Lo, Miroslav Cuturic, Vicki Segro, Kate Greenly, Fredy Revilla, Enrique Urrea-Mendoza, Kevin J. Black, Thomas Davis, Natividad Stover, Andrew Duker, Jay Van Gerpen, Peter Hedera, William Ondo, Karen Anderson, Stephen Bradley, Ken Cheung, Samuel Frank

Publikováno v: The Lancet Neurology. 22:494-504

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9521bbc7c5886201c53a98dc988016d
https://doi.org/10.1016/s1474-4422(23)00127-8

Data-driven evolution of neurosurgical gene therapy delivery in Parkinson’s disease

Autor: Russell R. Lonser, Robert E. Gross, Amber D. Van Laar, R. Mark Richardson, Chadwick W. Christine, Sandra K. Kostyk, Bernard Ravina, Stewart A. Factor, Paul S. Larson, Krystof S. Bankiewicz, Adrian P. Kells

Publikováno v: Journal of Neurology, Neurosurgery, and Psychiatry

Loss of nigrostriatal dopaminergic projection neurons is a key pathology in Parkinson’s disease, leading to abnormal function of basal ganglia motor circuits and the accompanying characteristic motor features. A number of intraparenchymally deliver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e26bfd5e9e7896e82b66f15268073b
https://doi.org/10.1136/jnnp-2020-322904

Safety and Tolerability of SRX246, a Vasopressin 1a Antagonist, in Irritable Huntington’s Disease Patients—A Randomized Phase 2 Clinical Trial

Autor: Melanie Benge, Amie L. Hiller, Carolyn Gray, Michele Costigan, H. Diana Rosas, Stephanie Lowenhaupt, Rosalind S Chuang, Peter Hedera, Danny Bega, Matthew J. Barrett, Marianne Chase, Jon W. Yankey, Jessica Lamb, Elaine Sperin, Susan Perlman, Christina Gruenwald, Joseph F. Quinn, Joyce Ann Moran, Lauren Seeberger, Debra E Itzkowitz, Brenton A Wright, Kelly Lowen, Karen E. Anderson, Victor W. Sung, Angela Molloy, Frederick J. Marshall, Patricia Conlon, Hilda T Maibach, Jamie L Adams, Elaine Most, Stewart A. Factor, Karen Marder, Allison M. Daley, Shifang Lu, Carlos Singer, Michael J Brownstein, Neal G. Simon, Amy M Chesire, Valerie Suski, Codrin Lungu, Kellie Keith, Christopher S. Coffey, Guy J Schwartz, Zsazsa R Brown, Richard Dubinsky, Catherine Gladden, Paola Wall, Jeremy M. Shefner, Steven M. Hersch, Cara Jacob, Jeffrey D. Long, Dixie Ecklund, Padraig E. O'Suilleabhain, Andrew P. Duker, J. Singleton, Meghan Zorn, Carolyn Drazinic, Mark Quigg, Eve M Damiano, Sandra K. Kostyk, Brenda Thornell, Andrew McGarry, Merit Cudkowicz, Robin Conwit, Paul Deritis, Joel S. Perlmutter

Publikováno v: Journal of Clinical Medicine
Volume 9
Issue 11
Journal of Clinical Medicine, Vol 9, Iss 3682, p 3682 (2020)

SRX246 is a vasopressin (AVP) 1a receptor antagonist that crosses the blood-brain barrier. It reduced impulsive aggression, fear, depression and anxiety in animal models, blocked the actions of intranasal AVP on aggression/fear circuits in an experim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6ab53df7b21fa094318e696048bfcc

Immediate effects of treadmill walking in individuals with Lewy body dementia and Huntington's disease

Autor: Robin Schubert, Douglas W. Scharre, Yubo Tan, Deb A. Kegelmeyer, Gregory S. Young, Nora E. Fritz, Ralf Reilmann, Anne D. Kloos, Sandra K. Kostyk

Publikováno v: Gaitposture. 86

Background Treadmill training may improve gait disorders associated with neurodegenerative diseases. In Parkinson’s disease (PD), treadmill training alters gait patterns after one session, and long-term training improves gait parameters, fall risk,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d80945890b52f5a2a931cd58e079985
https://pubmed.ncbi.nlm.nih.gov/33756407