Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Sandra Jordaan"'
1
Akademický článek
Updates in the Development of ImmunoRNases for the Selective Killing of Tumor Cells
Autor: Sandra Jordaan, Olusiji A. Akinrinmade, Thomas Nachreiner, Christian Cremer, Krupa Naran, Shivan Chetty, Stefan Barth
Publikováno v: Biomedicines, Vol 6, Iss 1, p 28 (2018)
Targeted cancer therapy includes, amongst others, antibody-based delivery of toxic payloads to selectively eliminate tumor cells. This payload can be either a synthetic small molecule drug composing an antibody-drug conjugate (ADC) or a cytotoxic pro
Externí odkaz: https://doaj.org/article/66c4f9f9103a4660be7438b5d9de26a3
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2
Akademický článek
Human MAP Tau Based Targeted Cytolytic Fusion Proteins
Autor: Olusiji A. Akinrinmade, Sandra Jordaan, Dmitrij Hristodorov, Radoslav Mladenov, Neelakshi Mungra, Shivan Chetty, Stefan Barth
Publikováno v: Biomedicines, Vol 5, Iss 3, p 36 (2017)
Some of the most promising small molecule toxins used to generate antibody drug conjugates (ADCs) include anti-mitotic agents (e.g., auristatin and its derivatives) which are designed to attack cancerous cells at their most vulnerable state during mi
Externí odkaz: https://doaj.org/article/b58b69018c914f209e1a2ad9b38d89fb
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3
Akademický článek
Designing the Sniper: Improving Targeted Human Cytolytic Fusion Proteins for Anti-Cancer Therapy via Molecular Simulation
Autor: Anna Bochicchio, Sandra Jordaan, Valeria Losasso, Shivan Chetty, Rodrigo Casasnovas Perera, Emiliano Ippoliti, Stefan Barth, Paolo Carloni
Publikováno v: Biomedicines, Vol 5, Iss 1, p 9 (2017)
Targeted human cytolytic fusion proteins (hCFPs) are humanized immunotoxins for selective treatment of different diseases including cancer. They are composed of a ligand specifically binding to target cells genetically linked to a human apoptosis-ind
Externí odkaz: https://doaj.org/article/84a6e6881deb49c7ace63c399f423782
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4
CSPG4
Autor: Stefan Barth, Sandra Jordaan, Peter E. van Bommel, Wijnand Helfrich, Iris Koopmans, Neelakshi Mungra, Shivan Chetty
Publikováno v: Biomedicines
Chondroitin-sulfate proteoglycan 4 (CSPG4) is a transmembrane glycoprotein overexpressed on malignant cells in several cancer types with only limited expression on normal cells. CSPG4 is implicated in several signaling pathways believed to drive canc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943ca5451285ed5aa56390cf5d437ff7
https://doi.org/10.3390/biomedicines5030037
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5
Human MAP tau based targeted cytolytic fusion proteins
Autor: Shivan Chetty, Neelakshi Mungra, Sandra Jordaan, Olusiji A. Akinrinmade, Dmitrij Hristodorov, Radoslav Mladenov, Stefan Barth
Publikováno v: Biomedicines, Vol 5, Iss 3, p 36 (2017)
Biomedicines
Some of the most promising small molecule toxins used to generate antibody drug conjugates (ADCs) include anti-mitotic agents (e.g auristatin and its derivatives) which are designed to attack cancerous cells at their most vulnerable state during mito
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586f97c028801982f900a97b4da2b01e
https://publica.fraunhofer.de/handle/publica/253674
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7
Acridine-containing RuII , OsII , RhIII and IrIII Half-Sandwich Complexes: Synthesis, Structure and Antiproliferative Activity
Autor: Sandra Jordaan, Asanda C. Matsheku, Banothile C. E. Makhubela, Gregory S. Smith, Sharon Prince, Marian Y.-H. Chen
Publikováno v: Applied Organometallic Chemistry. 31:e3852
Research aimed at enhancing the efficacy of organometallic complexes against cancer, has shown that attaching bio-active molecules to (metallo)drugs often enhances their biological properties. New salicylaldimine and 2-pyridylimine ligands (L2 and L3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f2bc0745659b1ad7a7714290284d0ae
https://doi.org/10.1002/aoc.3852
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8
Designing the Sniper: Improving Targeted Human Cytolytic Fusion Proteins for Anti-Cancer Therapy via Molecular Simulation
Autor: Emiliano Ippoliti, Sandra Jordaan, Valeria Losasso, Paolo Carloni, Anna Bochicchio, Shivan Chetty, Rodrigo Casasnovas Perera, Stefan Barth
Publikováno v: Biomedicines : open access journal 5(1), 9 (2017). doi:10.3390/biomedicines5010009 special issue: "Special Issue "Targeted Human Cytolytic Fusion Proteins" / Guest Editor Prof. Dr. Stefan Barth, Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, UCT, South Africa"
Biomedicines, Vol 5, Iss 1, p 9 (2017)
Biomedicines 5(1), 9 (2017). doi:10.3390/biomedicines5010009
Biomedicines
Biomedicines : open access journal 5(1), 9 (2017). doi:10.3390/biomedicines5010009 special issue: "Special Issue "Targeted Human Cytolytic Fusion Proteins" / Guest Editor Prof. Dr. Stefan Barth, Department of Integrative Biomedical Sciences, Institut
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adec7a1b48255c36b3982aa9d11b3e62
https://doi.org/10.3390/biomedicines5010009
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9
Targeted human cytolytic fusion proteins at the cutting edge: Harnessing the apoptosis-inducing properties of human enzymes for the selective elimination of tumor cells
Autor: Krupa Naran, Sandra Jordaan, Shivan Chetty, Stefan Barth, Neelakshi Mungra, Precious Hlongwane
Publikováno v: Scopus-Elsevier
Oncotarget
Patient-specific targeted therapy represents the holy grail of anti-cancer therapeutics, allowing potent tumor depletion without detrimental off-target toxicities. Disease-specific monoclonal antibodies have been employed to bind to oncogenic cell-su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52bdb80c7c25fb23ed3a12c6217d6dcf
http://www.scopus.com/inward/record.url?eid=2-s2.0-85060826728&partnerID=MN8TOARS
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