Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Sandra J. van Vliet"'
Autor:
Kelly Boelaars, Ernesto Rodriguez, Zowi R. Huinen, Chang Liu, Di Wang, Babet O. Springer, Katarzyna Olesek, Laura Goossens-Kruijssen, Thomas van Ee, Dimitri Lindijer, Willemijn Tak, Aram de Haas, Laetitia Wehry, Joline P. Nugteren-Boogaard, Aleksandra Mikula, Charlotte M. de Winde, Reina E. Mebius, David A. Tuveson, Elisa Giovannetti, Maarten F. Bijlsma, Manfred Wuhrer, Sandra J. van Vliet, Yvette van Kooyk
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Despite recent advances in cancer immunotherapy, pancreatic ductal adenocarcinoma (PDAC) remains unresponsive due to an immunosuppressive tumor microenvironment, which is characterized by the abundance of cancer-associated fibroblasts (CAFs)
Externí odkaz:
https://doaj.org/article/89d397e7c86647f4a8efdf005a8b83cc
Autor:
Ernesto Rodriguez, Dimitri V. Lindijer, Sandra J. van Vliet, Juan J. Garcia Vallejo, Yvette van Kooyk
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109037- (2024)
Summary: Changes in glycosylation patterns have been associated with malignant transformation and clinical outcomes in several cancer types, prompting ongoing research into the mechanisms involved and potential clinical applications. In this study, w
Externí odkaz:
https://doaj.org/article/9d2bd95a3952445a95f863798e4ae5eb
Autor:
Brigitte-Carole Keumatio Doungtsop, MSc, Eleonora Nardini, MSc, Hakan Kalay, BSc, Serge A. Versteeg, MSc, Joyce Lübbers, PhD, Gaby van Barneveld, MSc, Eveline R.J. Li, PhD, Sandra J. van Vliet, PhD, Ronald van Ree, PhD, Esther C. de Jong, PhD, Yvette van Kooyk, PhD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 1, Pp 100193- (2024)
Background: House dust mite extract–based allergen immunotherapy (AIT) to treat house dust mite allergy is substantially effective but still presents some safety and efficacy concerns that warrant improvement. Several major allergen-based approache
Externí odkaz:
https://doaj.org/article/7470b0bb5873499a871f5e4c9cea61fc
Autor:
Ernesto Rodriguez, Kelly Boelaars, Kari Brown, Katarina Madunić, Thomas van Ee, Frederike Dijk, Joanne Verheij, R. J. Eveline Li, Sjoerd T. T. Schetters, Laura L. Meijer, Tessa Y. S. Le Large, Else Driehuis, Hans Clevers, Sven C. M. Bruijns, Tom O’Toole, Sandra J. van Vliet, Maarten F. Bijlsma, Manfred Wuhrer, Geert Kazemier, Elisa Giovannetti, Juan J. Garcia-Vallejo, Yvette van Kooyk
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Rodriguez et al. present a transcriptomic analysis of glycosylation associated gene profiles, including bulk patient sequencing, sc-RNA seq, cell lines and organoids, to examine glycosylation in PDAC. They find 2 specific glycan profiles correlating
Externí odkaz:
https://doaj.org/article/733f6ecaba10448ebbd86e176c3ab7d9
Autor:
Dorian A. Stolk, Sophie K. Horrevorts, Sjoerd T.T. Schetters, Laura J.W. Kruijssen, Sanne Duinkerken, Eelco Keuning, Martino Ambrosini, Hakan Kalay, Rieneke van de Ven, Juan J. Garcia-Vallejo, Tanja D. de Gruijl, Sandra J. van Vliet, Yvette van Kooyk
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss , Pp 315-328 (2021)
Induction of tumor-specific cytotoxic CD8+ T cells (CTLs) via immunization relies on the presentation of tumor-associated peptides in major histocompatibility complex (MHC) class I molecules by dendritic cells (DCs). To achieve presentation of exogen
Externí odkaz:
https://doaj.org/article/2ff62c35b69d455394582a46f07cde98
Autor:
Ernesto Rodriguez, Kelly Boelaars, Kari Brown, R. J. Eveline Li, Laura Kruijssen, Sven C. M. Bruijns, Thomas van Ee, Sjoerd T. T. Schetters, Matheus H. W. Crommentuijn, Joost C. van der Horst, Nicole C. T. van Grieken, Sandra J. van Vliet, Geert Kazemier, Elisa Giovannetti, Juan J. Garcia-Vallejo, Yvette van Kooyk
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Alterations in glycosylation in tumours facilitate tumour progression. Here, the authors show that pancreatic ductal adenocarcinomas present increased sialylation, which stimulates the polarisation of monocytes via Siglec receptors, resulting in the
Externí odkaz:
https://doaj.org/article/64cd1d7410f74f27b60dd9aca97082ae
Autor:
Valeria da Costa, Karina V. Mariño, Santiago A. Rodríguez-Zraquia, María Florencia Festari, Pablo Lores, Monique Costa, Mercedes Landeira, Gabriel A. Rabinovich, Sandra J. van Vliet, Teresa Freire
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 12047 (2022)
Lung cancer is the first leading cause of cancer-related deaths in the world. Aberrant glycosylation in lung tumors leads to the expression of tumor-associated carbohydrate structures, such as the Tn antigen, consisting of N-acetyl-galactosamine (Gal
Externí odkaz:
https://doaj.org/article/2e8678524f034f30ab41b7fcad0baaac
Autor:
Rui-Jún Eveline Li, Aram de Haas, Ernesto Rodríguez, Hakan Kalay, Anouk Zaal, Connie R. Jimenez, Sander R. Piersma, Thang V. Pham, Alex A. Henneman, Richard R. de Goeij-de Haas, Sandra J. van Vliet, Yvette van Kooyk
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Dendritic cells (DCs) are key initiators of the adaptive immunity, and upon recognition of pathogens are able to skew T cell differentiation to elicit appropriate responses. DCs possess this extraordinary capacity to discern external signals using re
Externí odkaz:
https://doaj.org/article/940058aa5a7547b08562962f35f58f1e
Autor:
Juan M. Ilarregui, Gijs Kooij, Ernesto Rodríguez, Susanne M. A. van der Pol, Nathalie Koning, Hakan Kalay, Joost C. van der Horst, Sandra J. van Vliet, Juan J. García-Vallejo, Helga E. de Vries, Yvette van Kooyk
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)
Abstract Background Multiple sclerosis (MS) involves a misdirected immune attack against myelin in the brain and spinal cord, leading to profound neuroinflammation and neurodegeneration. While the mechanisms of disease pathogenesis have been widely s
Externí odkaz:
https://doaj.org/article/22f87aeffcb24a268513be628fe3e17d
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/b81b70f056774d448a1da5885fb1e3eb