Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sandra J. Hoffman"'
An intestinal organoid–based platform that recreates susceptibility to T-cell–mediated tissue injury
Autor:
Eugene Rudensky, Jennifer Tsai, Sandra J. Hoffman, Victor J. Torres, David Hudesman, Chen Liu, John Bertin, Ken Cadwell, Thomas Heaney, Brad J. Geddes, Marcel R.M. van den Brink, Jordan E. Axelrad, Yu Matsuzawa-Ishimoto, Xiaomin Yao, Allison M. Beal, Frank Yeung, P'ng Loke, Yusuke Shono, Ashley M. Hine, Jessica A Neil, Samantha L. Schuster, Michael Cammer, Ying-Han Chen, Amina Lazrak, Erin E Zwack, M. Zahidunnabi Dewan, Katherine B Nichols
Publikováno v:
Blood. 135:2388-2401
A goal in precision medicine is to use patient-derived material to predict disease course and intervention outcomes. Here, we use mechanistic observations in a preclinical animal model to design an ex vivo platform that recreates genetic susceptibili
Autor:
Stéphane Sautet, Emilie Jigorel, Nicolas Faucher, Jamel Meslamani, Lara Kathryn Leister, Pascal Grondin, Julie A. Cox, Bryan W. King, Pamela Nassau, Gemma Victoria White, Brad J. Geddes, Alain Claude-Marie Daugan, Helen H. Sun, Michael T. Ouellette, Pauline Lamoureux, Elizabeth J. Rivera, Scott B. Berger, James H. Thorpe, Philip A. Harris, J. Mosley, Susan E. Hutchinson, Frédéric Donche, John Bertin, Sandra J. Hoffman, Natalie Wellaway, Patrick M. Eidam, Paris Ward, Florent Potvain, Clark A. Sehon, Sebastien Andre Campos, Robert W. Marquis, Peter J. Gough, Mukesh K. Mahajan, Veronique Beneton, Jae U. Jeong, Michelle C. Schaeffer, John D. Lich, Allison M. Beal, Rakesh Nagilla, James Michael Woolven, Bonnie L. Hoffman, Anderson Niall Andrew, Marie-Hélène Fouchet, Deepak Bandyopadhyay, Carol A. Capriotti, Rachel D. Totoritis, Joshua N. Finger, Kishore K. Pasikanti, David D. Wisnoski, Sze-Ling Ng, Nino Campobasso, Nicolas George, Michael Reilly
Publikováno v:
Journal of Medicinal Chemistry. 62:5096-5110
RIP1 kinase regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including inflammatory and neurological diseases. Currently, RIP1 kinase inhibitors have advanced into early clinical
Autor:
Xiaoyang Dong, Anna Vossenkämper, Attiq Rahman, Viera Kasparcova, Robert Singhaus, Joshua N. Finger, Bryan W. King, Patrick M. Eidam, Michael Reilly, David D. Wisnoski, Scott B. Berger, John D. Lich, James Kang, Michael T. Ouellette, Lauren Dare, Philip A. Harris, Julie A. Cox, Nathan A. Miller, John Bertin, Michelle C. Schaeffer, Deepak Bandyopadhyay, Daohua Zhang, Alan R. Rendina, Clark A. Sehon, Sandra J. Hoffman, Peter J. Gough, Rachel D. Totoritis, Thomas T. MacDonald, Yunfeng Lan, Paris Ward, Barbara A. Swift, Robert W. Marquis, Lara Kathryn Leister, Rakesh Nagilla, Elizabeth J. Rivera, Helen H. Sun, Carol A. Capriotti, Nino Campobasso, Ruth Lehr, Christina S. Pao, Jae U. Jeong
Publikováno v:
Journal of Medicinal Chemistry. 60:1247-1261
RIP1 regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including immune-mediated inflammatory diseases. Small-molecule inhibitors of RIP1 kinase that are suitable for advancement
Autor:
Shunsuke Otani, Eileen M. Burd, Scott B. Berger, Craig M. Coopersmith, Kristal M. Maner-Smith, John Bertin, Sandra J. Hoffman, Alexandra DeLaney, Gregory K. Tharp, Michelle C. Schaeffer, Linda Roback, Carol A. Capriotti, Peter J. Gough, Cedrick Young, Steven E. Bosinger, Zhe Liang, Nelson C. DiPaolo, Edward S. Mocarski, Dmitry M. Shayakhmetov, Igor E. Brodsky, Yanjun Feng, Pratyusha Mandal, John D. Lyons, Eric A. Ortlund
Summary The execution of shock following high dose E. coli lipopolysaccharide (LPS) or bacterial sepsis in mice required pro-apoptotic caspase-8 in addition to pro-pyroptotic caspase-11 and gasdermin D. Hematopoietic cells produced MyD88- and TRIF-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fbdf244c275c03e848f8c2615710ce
https://europepmc.org/articles/PMC6064639/
https://europepmc.org/articles/PMC6064639/
Autor:
Lorraine A. Fitzpatrick, Sanjay Kumar, Jacquelin Jolette, Peter Mansell, Susan Y. Smith, Robert E. Guldberg, Rana Samadfam, Sandra J. Hoffman
Publikováno v:
Journal of Bone and Mineral Research. 28:1653-1665
Rosiglitazone (RSG) is an antidiabetic drug that has been associated with increased peripheral fractures, primarily in postmenopausal women. In this report, we investigated the underlying mechanisms of RSG-associated bone loss in ovariectomized (OVX)
Autor:
Michelle C. Schaeffer, Peter J. Gough, James Kang, Viera Kasparcova, Jae U. Jeong, LaShadric C. Grady, Joshua N. Finger, Paris Ward, Daohua Zhang, Robert W. Marquis, Lauren Dare, Michael T. Ouellette, Deepak Bandyopadhyay, Rakesh Nagilla, Xiaoyang Dong, Carol A. Capriotti, Christina S. Pao, Nino Campobasso, Rachel D. Totoritis, Philip A. Harris, Ruth Lehr, Jennifer Summerfield, Bryan W. King, Ami S. Lakdawala, Julie A. Cox, Barbara A. Swift, Aming Zhang, Scott B. Berger, John Bertin, Dean E. McNulty, Alan R. Rendina, Sandra J. Hoffman
Publikováno v:
Journal of medicinal chemistry. 59(5)
The recent discovery of the role of receptor interacting protein 1 (RIP1) kinase in tumor necrosis factor (TNF)-mediated inflammation has led to its emergence as a highly promising target for the treatment of multiple inflammatory diseases. We screen
Autor:
Vernal R. Vaden, Janice A. Vasko, Lago Amparo M, John Fox, Sanjay Kumar, William F. Huffman, Maggie Schultz, Hyking Haley, James F. Callahan, Xiaoguang Liang, Bingming Yi, Theodore M. Danoff, Lorraine A. Fitzpatrick, M. Gowen, George B. Stroup, Nemeth Edward F, Christopher Matheny, Sandra J. Hoffman, Eric G. Delmar, Robert W. Marquis, Pradip K. Bhatnagar
Publikováno v:
Bone. 46:534-542
Daily subcutaneous administration of exogenous parathyroid hormone (PTH) promotes bone formation in patients with osteoporosis. Here we describe two novel, short-acting calcium-sensing receptor antagonists (SB-423562 and its orally bioavailable precu
Autor:
Janice A. Vasko-Moser, Sandra J. Hoffman, Michael W. Lark, William H. Miller, George B. Stroup, Maxine Gowen
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 302:205-211
An excess of thyroid hormone results in increased bone turnover and loss of bone mass in humans. Exogenous administration of thyroid hormone to rats has served as a model of human hyperthyroidism in which antiresorptive therapies have been tested. We
Autor:
Robert W. Marquis, Karl F. Erhard, Sandra J. Hoffman, Daniel F. Veber, Maxine Gowen, Ru Yu, Lauren Dare, Brian R. Smith, Michael W. Lark, Thadeus Tomaszek, Janice A. Vasko-Moser, Amit Bhattacharyya, Ian E. James, Simon M. Blake, George B. Stroup
Publikováno v:
Journal of Bone and Mineral Research. 16:1739-1746
Cathepsin K is a cysteine protease that plays an essential role in osteoclast-mediated degradation of the organic matrix of bone. Knockout of the enzyme in mice, as well as lack of functional enzyme in the human condition pycnodysostosis, results in
Autor:
David J. Rieman, William F. Huffaman, Kevin L. Salyers, Richard M. Keenan, Michael W. Lark, Janice A. Vasko-Moser, Thomas W. Ku, Maxine Gowen, Leonard M. Azzarano, Karl F. Erhard, Stephen T. Ross, Denise Zembryki, Bradbeer Jeremy N, Bondinell William E, Shing-Mei Hwang, William H. Miller, Kenneth A. Newlander, George B. Stroup, Beata Lechowska, Fred H. Drake, Keith W. Ward, Kyung O. Johanson, Brian R. Smith, Paula C. Adams, Ian E. James, R. Curtis Haltiwanger, Russell D. Cousins, Dalia R. Jakas, Sandra J. Hoffman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1807-1812
A new series of potent nonpeptide vitronectin receptor antagonists, based on a novel carbocyclic Gly-Asp mimetic, has been discovered. A representative of this series, SB 265123 (4), has 100% oral bioavailability in rats, and is orally active in vivo