Výsledky vyhledávání - "Sandra J. Baldwin"

Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor

Autor: Aili L. Lazaar, Jonathan Robertson, Sandra J. Baldwin, Ruth J. Mayer, Navin Goyal, Lucy Yang, Ruth Tal-Singer, Rebecca L. Boardley, Ian B. Wilkinson, Joseph Cheriyan, David E. Newby

Publikováno v: British Journal of Clinical Pharmacology. 81:971-979

LY is funded by a Wellcome Trust-GSK Translational Medicine and Therapeutics (TMAT) Studentship and a Raymond and Beverley Sackler Fellowship. IW is a British Heart Foundation Senior Clinical Fellow and both JC and IW are supported by the Cambridge N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04ba0ad814aec7b3b2cdc78178c63ba4
https://doi.org/10.1111/bcp.12855

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The safety, tolerability, and pharmacokinetic profile of GSK2838232, a novel 2nd generation HIV maturation inhibitor, as assessed in healthy subjects

Autor: Sandra J. Baldwin, Jianfeng Xu, Matt Davies, Jerry Jeffrey, Matthew Burke, Allan R Tenorio, Brian A. Johns, Elizabeth Gould, Amanda Peppercorn, Roxanne C. Jewell, Mark Johnson, Yu Lou

Publikováno v: Pharmacology researchperspectives. 6(4)

This work aimed to assess the safety, tolerability, pharmacokinetics (PK), and relative bioavailability of GSK2838232, an investigational HIV maturation inhibitor. GSK2838232 was administered over four dose-escalation studies in healthy subjects whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4413391e38d9e7f99b7279ba5b19681d
https://pubmed.ncbi.nlm.nih.gov/29930812

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CYTOCHROME P450 GENE INDUCTION IN RATS EX VIVO ASSESSED BY QUANTITATIVE REAL-TIME REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION (TAQMAN)

Autor: Charlotte A. Ashby, Stephen E. Clarke, Andrew Ayrton, Sandra J. Baldwin, Lin Yue, Jo L. Bramhall, Steven R. Hood, Paul R. Murdock

Publikováno v: Drug Metabolism and Disposition. 34:1063-1069

Drug-induced changes in expression of cytochrome P450 (P450) genes are a significant issue in the preclinical development of pharmaceuticals. For example, preclinically, P450 induction can affect safety studies by reducing the systemic exposure of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2a500b4d32e7c80e7e56fa91dd34e2
https://doi.org/10.1124/dmd.105.008185

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Pharmacokinetics of the novel, high-affinity and selective dopamine D3 receptor antagonist SB-277011 in rat, dog and monkey:in vitro/in vivocorrelation and the role of aldehyde oxidase

Autor: Kevin M. Thewlis, Sandra J. Baldwin, C. E. Shardlow, P. J. Kelly, P. Jeffrey, Nigel Deeks, Leanne Cutler, Andrew Ayrton, Geoffrey Stemp, Nigel E. Austin, M. Nash

Publikováno v: Xenobiotica. 31:677-686

1. In vitro studies with the selective dopamine D3 receptor antagonist SB-277011 were conducted in liver microsomes and homogenates from rat, dog, cynomolgus monkey and human to correlate the rate of metabolism with the in vivo pharmacokinetics of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d43cd3f1671913b36b08b27781fbac3
https://doi.org/10.1080/00498250110056531

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Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron

Autor: Jackie C. Bloomer, Sandra J. Baldwin, S E Clarke, R J Chenery, G J Smith, Andrew Ayrton

Publikováno v: British Journal of Clinical Pharmacology. 38:557-566

1. The metabolism of granisetron was investigated in human liver microsomes to identify the specific forms of cytochrome P450 responsible. 2. 7-hydroxy and 9'-desmethyl granisetron were identified as the major products of metabolism following incubat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd51d46c7ed1ac7e3bba5da19ec371c
https://doi.org/10.1111/j.1365-2125.1994.tb04397.x

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Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

Autor: Andrew Ayrton, R J Chenery, G J Smith, Sandra J. Baldwin, S E Clarke, Jackie C. Bloomer

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 25(3)

1. The potential of ketoconazole and sulphaphenazole to inhibit specific P450 enzyme activities (1A2, 2A6, 2B6, 2C9/8, 2C19, 2D6, 2E1, 3A and 4A) was investigated using human liver microsomes. 2. Ketoconazole demonstrated an inhibitory effect on cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa7227dff56423d2201c02f8e88052b
https://pubmed.ncbi.nlm.nih.gov/7618352

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Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes

Autor: Jacqueline C. Bloomer, Randall S. Sozio, Sandra J. Baldwin, Andrew Ayrton, Stephen E. Clarke, Richard J. Chenery

Publikováno v: Chemical research in toxicology. 7(6)

In vitro techniques have been utilized to investigate the microsomal enzymes involved in the metabolism of lauric acid and to establish conditions in which it can be used as a model substrate for both cytochrome P450 4A and cytochrome P450 2E1 in hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2be60b5ff1b3c050b0bc43ae4cbce1
https://pubmed.ncbi.nlm.nih.gov/7696540

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