Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Sandra J Hewett"'
Publikováno v:
ASN Neuro, Vol 4 (2012)
Despite longstanding evidence that hypoglycaemic neuronal injury is mediated by glutamate excitotoxicity, the cellular and molecular mechanisms involved remain incompletely defined. Here, we demonstrate that the excitotoxic neuronal death that follow
Externí odkaz:
https://doaj.org/article/826ae404c1724c76bf674350c59c597e
Autor:
Ellora Sen, Anirban Basu, Lisa B Willing, Tracy F Uliasz, Jaimie L Myrkalo, Susan J Vannucci, Sandra J Hewett, Steven W Levison
Publikováno v:
ASN Neuro, Vol 3 (2011)
Hypoxic preconditioning reprogrammes the brain's response to subsequent H/I (hypoxia-ischaemia) injury by enhancing neuroprotective mechanisms. Given that astrocytes normally support neuronal survival and function, the purpose of the present study wa
Externí odkaz:
https://doaj.org/article/5506cf1b36bc423fb73e903f15dc40ce
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 17 (2023)
BackgroundSystem xc– (Sxc–) is an important heteromeric amino acid cystine/glutamate exchanger that plays a pivotal role in the CNS by importing cystine into cells while exporting glutamate. Although certain behaviors have been identified as alte
Externí odkaz:
https://doaj.org/article/3e0a8e0cdee24d1e851ab03220aec760
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/fc1a8fb140b7462da0c6c95880583811
Publikováno v:
J Neurosci Res
System x(c)(-) (Sx(c)(-)) is a heteromeric antiporter (L-cystine/L-glutamate exchanger) expressed predominately on astrocytes in the central nervous system. Its activity contributes importantly to the maintenance of the ambient extracellular glutamat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c626f6692e73bd305733315c266b867
https://doi.org/10.1002/jnr.24971
https://doi.org/10.1002/jnr.24971
Autor:
Spandita S. Dutta, Antoaneta A. Andonova, Torsten Wöellert, Sandra J. Hewett, James A. Hewett
Publikováno v:
Neurobiol Dis
Disruption of Interleukin-1β (IL-1β) signaling sensitized mice to convulsant stimuli, suggesting that this quintessential cytokine of the innate immune system contributes to maintenance of the innate seizure threshold (ST). However, much remains un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f4c61d36eab6d6914e55f3fc6f1845
https://europepmc.org/articles/PMC9067394/
https://europepmc.org/articles/PMC9067394/
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 1, Pp 234-242 (2012)
The function of endogenous interleukin-1β (IL-1β) signaling in acute seizure activity was examined using transgenic mice harboring targeted deletions in the genes for either IL-1β (Il1b) or its signaling receptor (Il1r1). Acute epileptic seizure a
Externí odkaz:
https://doaj.org/article/e47033ae0a2a4772af539506c74781dd
Autor:
Yan, He, Sandra J, Hewett
Publikováno v:
Frontiers in cellular neuroscience. 16
Understanding the mechanisms underlying ischemic brain injury is of importance to the goal of devising novel therapeutics for protection and/or recovery. Previous work in our laboratory and in others has shown that activation of cystine/glutamate ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e57e2fa9111d602ef42805914e1f95b
https://pubmed.ncbi.nlm.nih.gov/35669109
https://pubmed.ncbi.nlm.nih.gov/35669109
Publikováno v:
Epilepsia Open
Summary Objective Although the cystine/glutamate antiporter System xc − (Sxc −) plays a permissive role in glioma‐associated seizures, its contribution to other acquired epilepsies has not been determined. As such, the present study investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369b890e5e0e0527cb7dc9c87fff1699
https://doi.org/10.1002/epi4.12307
https://doi.org/10.1002/epi4.12307
Publikováno v:
Neurochemistry international. 144
Active and passive transporters constitute a gene family of approximately 2000 members. These proteins are required for import and export across the blood brain barrier, clearance of neurotransmitters, inter-cellular solute transfer, and transport ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162ac29378d7a78ce3b791137eb137d0
https://pubmed.ncbi.nlm.nih.gov/33524471
https://pubmed.ncbi.nlm.nih.gov/33524471