Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Sandra J, Hewett"'
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 17 (2023)
BackgroundSystem xc– (Sxc–) is an important heteromeric amino acid cystine/glutamate exchanger that plays a pivotal role in the CNS by importing cystine into cells while exporting glutamate. Although certain behaviors have been identified as alte
Externí odkaz:
https://doaj.org/article/3e0a8e0cdee24d1e851ab03220aec760
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/fc1a8fb140b7462da0c6c95880583811
Autor:
Spandita S. Dutta, Antoaneta A. Andonova, Torsten Wöellert, Sandra J. Hewett, James A. Hewett
Publikováno v:
Neurobiology of Disease, Vol 168, Iss , Pp 105689- (2022)
Disruption of Interleukin-1β (IL-1β) signaling sensitized mice to convulsant stimuli, suggesting that this quintessential cytokine of the innate immune system contributes to maintenance of the innate seizure threshold (ST). However, much remains un
Externí odkaz:
https://doaj.org/article/4be5702d753f4a77b7de945ac58b125c
Autor:
Yan He, Sandra J. Hewett
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Understanding the mechanisms underlying ischemic brain injury is of importance to the goal of devising novel therapeutics for protection and/or recovery. Previous work in our laboratory and in others has shown that activation of cystine/glutamate ant
Externí odkaz:
https://doaj.org/article/5e7623f510484fb2a1883a5d129d1c6d
Publikováno v:
J Neurosci Res
System x(c)(-) (Sx(c)(-)) is a heteromeric antiporter (L-cystine/L-glutamate exchanger) expressed predominately on astrocytes in the central nervous system. Its activity contributes importantly to the maintenance of the ambient extracellular glutamat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c626f6692e73bd305733315c266b867
https://doi.org/10.1002/jnr.24971
https://doi.org/10.1002/jnr.24971
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 1, Pp 234-242 (2012)
The function of endogenous interleukin-1β (IL-1β) signaling in acute seizure activity was examined using transgenic mice harboring targeted deletions in the genes for either IL-1β (Il1b) or its signaling receptor (Il1r1). Acute epileptic seizure a
Externí odkaz:
https://doaj.org/article/e47033ae0a2a4772af539506c74781dd
Publikováno v:
Antioxidants, Vol 7, Iss 8, p 100 (2018)
Interleukin-1β (IL-1β), a key cytokine that drives neuroinflammation in the Central Nervous System (CNS), is enhanced in many neurological diseases/disorders. Although IL-1β contributes to and/or sustains pathophysiological processes in the CNS, w
Externí odkaz:
https://doaj.org/article/1f6f70bc191b4542b00e91289273a20c
Autor:
Yan, He, Sandra J, Hewett
Publikováno v:
Frontiers in cellular neuroscience. 16
Understanding the mechanisms underlying ischemic brain injury is of importance to the goal of devising novel therapeutics for protection and/or recovery. Previous work in our laboratory and in others has shown that activation of cystine/glutamate ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e57e2fa9111d602ef42805914e1f95b
https://pubmed.ncbi.nlm.nih.gov/35669109
https://pubmed.ncbi.nlm.nih.gov/35669109
Publikováno v:
ASN Neuro, Vol 7 (2015)
The astrocyte cystine/glutamate antiporter (system x c − ) contributes substantially to the excitotoxic neuronal cell death facilitated by glucose deprivation. The purpose of this study was to determine the mechanism by which this occurred. Using p
Externí odkaz:
https://doaj.org/article/0af5ee3359c240bb910e56410531664c
Publikováno v:
Epilepsia Open
Summary Objective Although the cystine/glutamate antiporter System xc − (Sxc −) plays a permissive role in glioma‐associated seizures, its contribution to other acquired epilepsies has not been determined. As such, the present study investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369b890e5e0e0527cb7dc9c87fff1699
https://doi.org/10.1002/epi4.12307
https://doi.org/10.1002/epi4.12307