Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sandra Huling"'
Autor:
Fredrick J. Suchy, Lien Nguyen, Hideyuki Hyogo, Steven R. Lear, Sandra Huling, Ashok K. Batta, Sandra K. Erickson, Ephraim Sehayek, Benjamin L. Shneider, Sandrine Dubrac, David E. Cohen, Jaya Bollineni, Meena Ananthanarayanan, Gerald Salen, Sean Deane, Natarajan Balasubramaniyan, Sarah Shefer
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 5, Pp 1001-1009 (2003)
Cholesterol 7alpha-hydroxylase, a rate-limiting enzyme for bile acid synthesis, has been implicated in genetic susceptibility to atherosclerosis. The gene, CYP7A1, encoding a protein with this activity, is expressed normally only in hepatocytes and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a306b6673b5272de45f6ac2fd30f525f
https://doi.org/10.1194/jlr.m200489-jlr200
https://doi.org/10.1194/jlr.m200489-jlr200
Autor:
Sandra Huling, Vivek Bhargava, Thomas Kuwahara, Elizabeth Hansell, James H. McKerrow, Robert S. Warren, Mary Matley, Lisa M. Coussens
Publikováno v:
Molecular Medicine. 6:450-460
Proteases facilitate several steps in cancer progression. To identify proteases most suitable for drug targeting, actual enzyme activity and not messenger RNA levels or immunoassay of protein is the ideal assay readout. An automated microtiter plate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1df1267414317bd9c8d0d1a3be9da1d
https://doi.org/10.1007/bf03401787
https://doi.org/10.1007/bf03401787
Publikováno v:
Hepatology. 28:1064-1072
Cholesterol 7α-hydroxylase is a rate-limiting enzyme in bile acid synthesis, a major pathway for cholesterol catabolism. It plays a crucial role in postnatal development and survival. In an adult liver, its activity and messenger RNA (mRNA) are hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867e7b7eb541326cc9b48e388e6b2213
https://doi.org/10.1002/hep.510280422
https://doi.org/10.1002/hep.510280422
Autor:
Alan Wells, Susan Jo Burwen, Ulrich Marti, Sandra Huling, Mary E. Barker, Albert L. Jones, Anna Feren
Publikováno v:
Hepatology. 13:15-20
Experiments undertaken to investigate the binding of epidermal growth factor by hepatocyte nuclei showed that: (a) isolated nuclei from both normal and regenerating rat liver are capable of binding 125I-epidermal growth factor, (b) the nuclear epider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fa243d3d5302dbd1eeb0f79c90b5851
https://doi.org/10.1002/hep.1840130104
https://doi.org/10.1002/hep.1840130104
Autor:
Sandra Huling, Kenneth R. Feingold, Judy K. Shigenaga, James A. Lausier, Arthur H. Moser, Janet L. Funk, Carl Grunfeld, Gordon J Strewler, Robert A. Nissenson
Publikováno v:
Endocrinology. 136(8)
PTH-related protein (PTHrP), the peptide that is responsible for most cases of hypercalcemia of malignancy, is also produced under normal circumstances by a variety of tissues. Its role and regulation at these sites are not well understood. Recently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adef170b686f5cfb81219f05bb29a8c6
https://pubmed.ncbi.nlm.nih.gov/7628377
https://pubmed.ncbi.nlm.nih.gov/7628377
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 89(10)
In the rat, secretion of polymeric IgA from serum into bile is dependent upon the presence of a functional polymeric immunoglobulin receptor (pIgR) that acts as a hepatocyte plasma membrane receptor for ligand binding and as a transcellular transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95aa556778d97e2a2e0b3f05205a155f
https://pubmed.ncbi.nlm.nih.gov/1374892
https://pubmed.ncbi.nlm.nih.gov/1374892
Autor:
Henry S. Gaines, Gary T. Hradek, Brian J. Underdown, Sandra Huling, Albert L. Jones, William D. Christiansen
Publikováno v:
Hepatology. 2:769-776
It is well documented that the liver provides an important source of secretory immunoglobulin A (sIgA) in the gut fluid. In the rat, liver parenchymal cells can actively sequester the dimeric form of IgA (dIgA) from plasma and transfer it attached to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e4b570381e8194c1ed2d1e451ffadc
https://doi.org/10.1002/hep.1840020604
https://doi.org/10.1002/hep.1840020604
Publikováno v:
Gastroenterology. 84:978-985
17 alpha-Ethynyl estradiol-induced cholestasis was used to study the relationship of protein to bile salt transport in liver. The biliary secretion of horseradish peroxidase was unaltered in treated animals despite a 56% reduction in bile flow. Cytoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bc0f1f354ebab3862932aa01f71ce85
https://doi.org/10.1016/0016-5085(83)90200-7
https://doi.org/10.1016/0016-5085(83)90200-7
Publikováno v:
Biochemical and Biophysical Research Communications. 88:605-612
Mevalonic acid exists in two forms at physiologic pH: an open-chain salt and a cyclic lactone. Studies by others have demonstrated preferential utilization of the salt by the brain and of mevalonolactone by isolated hepatocytes. The major finding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e56990f8a2ea8d84f9ecf6e5cdb00c7
https://doi.org/10.1016/0006-291x(79)92091-6
https://doi.org/10.1016/0006-291x(79)92091-6
Publikováno v:
Journal of Cellular Biochemistry. 40:109-119
Experiments were undertaken to determine whether the method of iodination of epidermal growth factor (EGF) affects its binding to rat liver plasma membranes and its uptake, processing, and secretion into bile by intact rat hepatocytes. EGF was iodina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f67069d0027f2f9c4b1c4cd59cc88d
https://doi.org/10.1002/jcb.240400111
https://doi.org/10.1002/jcb.240400111