A Mouse Model of Mild Clostridioides difficile Infection for the Characterization of Natural Immune Responses

Autor: Assaf Mizrahi, Gauthier Péan de Ponfilly, Diane Sapa, Antonia Suau, Irène Mangin, Aurélie Baliarda, Sandra Hoys, Benoît Pilmis, Sylvie Lambert, Anaïs Brosse, Alban Le Monnier

Publikováno v: Microorganisms, Vol 12, Iss 10, p 1933 (2024)

(1) Background: We describe a model of primary mild-Clostridioides difficile infection (CDI) in a naïve host, including gut microbiota analysis, weight loss, mortality, length of colonization. This model was used in order to describe the kinetics of

Externí odkaz: https://doaj.org/article/bc3bddd68fcb42f090688faca0c469ea

Biofilm Structures in a Mono-Associated Mouse Model of Clostridium difficile Infection

Autor: Anna P. Soavelomandroso, Françoise Gaudin, Sandra Hoys, Valérie Nicolas, Gayatri Vedantam, Claire Janoir, Sylvie Bouttier

Publikováno v: Frontiers in Microbiology, Vol 8 (2017)

Clostridium difficile infection (CDI) is a major healthcare-associated disease with high recurrence rates. Host colonization is critical for the infectious process, both in first episodes and in recurrent disease, with biofilm formation playing a key

Externí odkaz: https://doaj.org/article/69d15acc22274c05b865d2f30e2baacb

The flagellin FliC of Clostridium difficile is responsible for pleiotropic gene regulation during in vivo infection.

Autor: Amira Barketi-Klai, Marc Monot, Sandra Hoys, Sylvie Lambert-Bordes, Sarah A Kuehne, Nigel Minton, Anne Collignon, Bruno Dupuy, Imad Kansau

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96876 (2014)

Clostridium difficile is the main agent responsible for hospital acquired antibiotic associated diarrhoea. In recent years, epidemic strains have emerged causing more severe infections. Whilst C. difficile has two major virulence factors, toxins TcdA

Externí odkaz: https://doaj.org/article/aac4d9af67094a46939704320fb7a8c5

Characterization of Non-Toxigenic Clostridioides difficile Strains Isolated from Preterm Neonates and In Vivo Study of Their Protective Effect

Autor: Sandra Hoys, Claire Janoir, Anlyata Youssouf, Frédéric Barbut, Léa Franconeri, Julio Aires, Laurent Ferraris, Cécile Gateau, Rabab Syed-Zaidi, Jeanne Couturier

Publikováno v: Journal of Clinical Medicine, Vol 9, Iss 3650, p 3650 (2020)
Journal of Clinical Medicine
Journal of Clinical Medicine, 2020, 9 (11), pp.3650. ⟨10.3390/jcm9113650⟩
Volume 9
Issue 11
Journal of Clinical Medicine, MDPI, 2020, 9 (11), pp.3650. ⟨10.3390/jcm9113650⟩

In a previous monocentric study in preterm neonates (PN), we described a high Clostridioides difficile colonization rate (74%) with two uncommon non-toxigenic strains (NTCD) belonging to PCR-ribotype (RT) (CE)847 and (CE)032. To determine the extent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46951642828712c701fd14ce74e9fd66
https://www.mdpi.com/2077-0383/9/11/3650

Protection against Clostridium difficile infection in a hamster model by oral vaccination using flagellin FliC-loaded pectin beads

Autor: Nicolas Tsapis, Claire Janoir, Jean-François Bruxelle, Anne Collignon, Séverine Péchiné, Sandra Hoys, Elias Fattal

Publikováno v: Vaccine
Vaccine, Elsevier, 2018, 36 (40), pp.6017-6021. ⟨10.1016/j.vaccine.2018.08.013⟩

International audience; Clostridium difficile flagellin FliC is a highly immunogenic pathogen-associated molecular pattern playing a key role in C. difficile pathogenesis and gut colonization. Here, we designed an oral vaccine against C. difficile wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6802ab37741fa969d6302e3469172cd
https://doi.org/10.1016/j.vaccine.2018.08.013