Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sandra Hoefgen"'
Autor:
Katarina Jojić, Fabio Gherlone, Zoltán Cseresnyés, Alexander U. Bissell, Sandra Hoefgen, Stefan Hoffmann, Ying Huang, Slavica Janevska, Marc Thilo Figge, Vito Valiante
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Sphingofungins are sphinganine analog mycotoxins acting as inhibitors of serine palmitoyl transferases, enzymes responsible for the first step in the sphingolipid biosynthesis. Eukaryotic cells are highly organized with various structures an
Externí odkaz:
https://doaj.org/article/1590b18aa1de4795b6dcabe17f244522
Autor:
Sandra Hoefgen, Alexander U. Bissell, Ying Huang, Fabio Gherlone, Luka Raguž, Christine Beemelmanns, Vito Valiante
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Serine palmitoyltransferase catalyzes the first step of the sphingolipid biosynthesis. Recently, sphingolipid homeostasis has been connected to several human diseases, making serine palmitoyltransferases an interesting therapeutic target. Kn
Externí odkaz:
https://doaj.org/article/a3b04fd7641243648624375f92b171f7
Autor:
Slavica Janevska, Iuliia Ferling, Katarina Jojić, Julia Rautschek, Sandra Hoefgen, Robert H. Proctor, Falk Hillmann, Vito Valiante
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Fumonisin (FB) mycotoxins produced by species of the genus Fusarium detrimentally affect human and animal health upon consumption, due to the inhibition of ceramide synthase. In the present work, we set out to identify mechanisms of self-pro
Externí odkaz:
https://doaj.org/article/b07819250cac40d8bbc977bfb407b14c
Autor:
Adriana Oliveira Manfiolli, Filipe Silva Siqueira, Thaila Fernanda dos Reis, Patrick Van Dijck, Sanne Schrevens, Sandra Hoefgen, Martin Föge, Maria Straßburger, Leandro José de Assis, Thorsten Heinekamp, Marina Campos Rocha, Slavica Janevska, Axel A. Brakhage, Iran Malavazi, Gustavo H. Goldman, Vito Valiante
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT The pathogenic fungus Aspergillus fumigatus is able to adapt to extremely variable environmental conditions. The A. fumigatus genome contains four genes coding for mitogen-activated protein kinases (MAPKs), which are important regulatory kno
Externí odkaz:
https://doaj.org/article/2a88a6e1f3f546b38da33b11a7706562
Autor:
Kourosh Honarmand Ebrahimi, Christian Dienemann, Sandra Hoefgen, Manuel E Than, Peter-Leon Hagedoorn, Wilfred R Hagen
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72177 (2013)
The ubiquitous 24-meric iron-storage protein ferritin and multicopper oxidases such as ceruloplasmin or hephaestin catalyze oxidation of Fe(II) to Fe(III), using molecular oxygen as oxidant. The ferroxidase activity of these proteins is essential for
Externí odkaz:
https://doaj.org/article/ca9b0d642a954b27964934071661ea99
Autor:
Alexander U. Bissell, Julia Rautschek, Sandra Hoefgen, Luka Raguž, Derek J. Mattern, Nauman Saeed, Slavica Janevska, Katarina Jojić, Ying Huang, Johann E. Kufs, Barbara Herboeck, Huijuan Guo, Falk Hillmann, Christine Beemelmanns, Vito Valiante
Publikováno v:
ACS Chem Biol
Sphingofungins belong to a group of structurally related sphingolipid inhibitors produced by fungi, which specifically inhibit serine palmitoyl transferases, enzymes catalyzing the initial step during sphingolipid biosynthesis. Sphingolipids are inte
Publikováno v:
Angewandte Chemie (International Ed. in English)
Drimane‐type sesquiterpenes exhibit various biological activities and are widely present in eukaryotes. Here, we completely elucidated the biosynthetic pathway of the drimane‐type sesquiterpene esters isolated from Aspergillus calidoustus and we
Publikováno v:
Angewandte Chemie. 134
Naturally occurring α-pyrones with biological activities are mostly synthesised by polyketide synthases (PKSs) via iterative decarboxylative Claisen condensation steps. Remarkably, we found that some enzymes related to the fatty acid β-oxidation pa
Publikováno v:
RSC Advances. 10:40588-40596
In the present work, microgels were utilized as a cell-free reaction environment to produce a functional malonyl-CoA synthetase (deGFP-MatB) under geometry-controlled transcription and translation. Our approach combines the straight-forward optimizat
Publikováno v:
RSC advances. 10(66)
In the present work, microgels were utilized as a cell-free reaction environment to produce a functional malonyl-CoA synthetase (deGFP-MatB) under geometry-controlled transcription and translation. Our approach combines the straight-forward optimizat