Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Sandra Hodge"'
Autor:
Greg Hodge, Hubertus Jersmann, Mark Holmes, Patrick Asare, Eugene Roscioli, Paul N. Reynolds, Sandra Hodge
Publikováno v:
Biology, Vol 12, Iss 9, p 1261 (2023)
Introduction: Pro-inflammatory CD8+ T cells are increased in the lungs and also in the peripheral circulation of both smokers and chronic obstructive pulmonary disease (COPD) patients. The reason for this is unclear but has been described as a spillo
Externí odkaz:
https://doaj.org/article/a2f00e34891a48c98c0515b1233566ce
Publikováno v:
Journal of Inflammation, Vol 17, Iss 1, Pp 1-12 (2020)
Abstract Background Inflammasomes and sphingosine-1-phosphate (S1P) signalling are increasingly subject to intensive research in human diseases. We hypothesize that in respiratory muco-obstructive diseases, mucus obstruction enhances NLRP3 inflammaso
Externí odkaz:
https://doaj.org/article/38b6d4bd2fd849b69fa1e93a0d78ff0c
Autor:
Patrick F. Asare, Hai B. Tran, Plinio R. Hurtado, Griffith B. Perkins, Phan Nguyen, Hubertus Jersmann, Eugene Roscioli, Sandra Hodge
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 15 (2021)
Introduction/Rationale: In chronic obstructive pulmonary disease (COPD), defective macrophage phagocytic clearance of cells undergoing apoptosis by efferocytosis may lead to secondary necrosis of the uncleared cells and contribute to airway inflammat
Externí odkaz:
https://doaj.org/article/dbd46a76f302486c98c0d1a21e6b7af5
Autor:
Patrick F. Asare, Eugene Roscioli, Plinio R. Hurtado, Hai B. Tran, Chui Yan Mah, Sandra Hodge
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
One aim of cancer therapies is to induce apoptosis of tumor cells. Efficient removal of the apoptotic cells requires coordinated efforts between the processes of efferocytosis and LC3-associated phagocytosis (LAP). However, this activity has also bee
Externí odkaz:
https://doaj.org/article/c6aad7c4f13643af813b7541e3130926
Autor:
Matthew G. Macowan, Hong Liu, Marianne D. Keller, Miranda Ween, Rhys Hamon, Hai B. Tran, Sandra Hodge
Publikováno v:
Physiological Reports, Vol 8, Iss 13, Pp n/a-n/a (2020)
Abstract Cigarette smoke (CS)‐induced emphysema is an important contributor to chronic obstructive pulmonary disease (COPD). We have shown the efficacy of azithromycin in reducing airway inflammation in COPD and in reducing exacerbations in severe
Externí odkaz:
https://doaj.org/article/33abb8dcb3f140a9b97d86d9bcca3274
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 14 (2020)
Background: The class III NAD-dependent histone deacetylase (HDAC) sirtuin 1 (SIRT1) is an important regulator of senescence, aging, and inflammation. SIRT1de-acetylates chromatin histones, thereby silencing inflammatory gene transcription. We have r
Externí odkaz:
https://doaj.org/article/f929d0fc1de84ab796fc790cd960fd5a
Autor:
Eugene Roscioli, Rhys Hamon, Susan E. Lester, Hubertus P. A. Jersmann, Paul N. Reynolds, Sandra Hodge
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background Individuals with respiratory disease are being increasingly exposed to wildfire smoke as populations encroach further into forested regions and climate change continues to bring higher temperatures with lower rainfall. Frequent ex
Externí odkaz:
https://doaj.org/article/0d5376415c6f40d2b6462a59dc73c7f9
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Bushfires are increasing in frequency and severity worldwide. Bushfire smoke contains organic/inorganic compounds including aldehydes and acrolein. We described suppressive effects of tobacco smoke on the phagocytic capacity of airway macrop
Externí odkaz:
https://doaj.org/article/951fb943ffdc4a01ae08074cd1554b4b
Autor:
Peter G. Gibson, Ian A. Yang, John W. Upham, Paul N. Reynolds, Sandra Hodge, Alan L. James, Christine Jenkins, Matthew J. Peters, Guy B. Marks, Melissa Baraket, Heather Powell, Jodie L. Simpson
Publikováno v:
ERJ Open Research, Vol 5, Iss 4 (2019)
Background Low-dose azithromycin is an effective therapy for persistent asthma; however, its benefit in severe asthma is not defined. Methods Participants with severe asthma were identified from the AMAZES randomised, placebo-controlled trial of long
Externí odkaz:
https://doaj.org/article/cf5d487e0add488f850f74735d2b3382
Autor:
Alice C-H. Chen, Hai B. Tran, Yang Xi, Stephanie T. Yerkovich, Katherine J. Baines, Susan J. Pizzutto, Melanie Carroll, Avril A.B. Robertson, Matthew A. Cooper, Kate Schroder, Jodie L. Simpson, Peter G. Gibson, Greg Hodge, Ian B. Masters, Helen M. Buntain, Helen L. Petsky, Samantha J. Prime, Anne B. Chang, Sandra Hodge, John W. Upham
Publikováno v:
ERJ Open Research, Vol 4, Iss 1 (2018)
Protracted bacterial bronchitis (PBB) in young children is characterised by prolonged wet cough, prominent airway interleukin (IL)-1β expression and infection, often with nontypeable Haemophilus influenzae (NTHi). The mechanisms responsible for IL-1
Externí odkaz:
https://doaj.org/article/38913608e0474e6c9cbe0fa34b676bac