Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sandra Hirschberg"'
Autor:
Ali JN Duabil, Christian R Cooper, Esraa Aldujaily, Sarah ER Halford, Sandra Hirschberg, Sidath D Katugampola, George DD Jones
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 6, Pp 1210-1226 (2023)
Aim: In response to DNA damage the serine/threonine-specific protein kinase checkpoint kinase 1 (CHK1) is activated allowing cells to enter S phase (S) and G2 phase (G2) cell-cycle arrest. CHK1 inhibitors are expected to prevent cells from entering s
Externí odkaz:
https://doaj.org/article/ec7ed657492f40f28f2f810abf6cf0d2
Autor:
Heather Cohen, Cara Bray, Drasti Kanakia, Johanna Lahdenranta, Punit Upadhyaya, Kristen Hurov, Julia Kristensson, Chintan Jobaliya, Greg Bannish, Adam Cotty, Kevin McDonnell, Sandra Hirschberg, Sebastien Hazard, Dominic Smethurst, Nicholas Keen, Stephen J Blakemore
Publikováno v:
Cancer Immunology Research. 10:A65-A65
Bicycles are fully synthetic constrained peptides with antibody-like affinities that target selectively, readily penetrate tumor tissue, have relatively short half-lives, and can be chemically linked together to generate multifunctional molecules. BT
Autor:
Heather Cohen, Drasti Kanakia, Johanna Lahdenranta, Punit Upadhyaya, Kristen Hurov, Julia Kristensson, Chintan Jobaliya, Greg Bannish, Adam Cotty, Kevin McDonnell, Sandra Hirschberg, Phil Brandish, Sebastien Hazard, Dominic Smethurst, Nicholas Keen, Stephen J. Blakemore
Publikováno v:
Cancer Research. 82:1976-1976
Bicycles are fully synthetic constrained peptides with antibody-like affinities that target selectively, readily penetrate tumor tissue, have relatively short half-lives, and can be chemically linked together to generate multifunctional molecules. BT
Autor:
Kyriakos P. Papadopoulos, Afshin Dowlati, Amy Dickson, Sandra Hirschberg, Sally Westrup, Punit Upadhyaya, Heather Cohen, Kristen Hurov, Roshawn Watson, Sebastien Hazard, Dominic Smethurst, Jordi Rodon Ahnert
Publikováno v:
Journal of Clinical Oncology. 40:TPS2689-TPS2689
TPS2689 Background: BT7480 is a novel, first-in-class, Nectin-4/CD137 Bicycle tumor-targeted immune cell agonist ( Bicycle TICA) that co-ligates cluster of differentiation (CD)137 (on immune cells) and Nectin-4 (on tumor cells). BT7480 comprises 3 bi
Autor:
Dennis L. Sprecher, Barbara A. Fielding, Stephen O'Rahilly, Keith N. Frayn, Duncan Richards, Samar Basu, Fredrik Karpe, Priti S. Hegde, Timothy M. Willson, Peter R. Murgatroyd, Zeke Fang, Niall R. Moore, Jay Strum, Theodore M. Danoff, Leli Sarov-Blat, Jane Cheeseman, Pauline Sutton, David G. Hassall, Sandy M. Humphreys, Eric Olson, Ulf Risérus, Tony G. Johnson, Aixue Liu, Sandra Hirschberg
Publikováno v:
Diabetes. 57:332-339
OBJECTIVE— Pharmacological use of peroxisome proliferator–activated receptor (PPAR)δ agonists and transgenic overexpression of PPARδ in mice suggest amelioration of features of the metabolic syndrome through enhanced fat oxidation in skeletal m
Autor:
Katia Georgopoulos, Dimitris Kioussis, Sandra Hirschberg, Marta Cortes, Arnd Hostert, Nicola Harker, Kathleen Roderick, Taku Naito, Mauro Tolaini
Publikováno v:
Molecular Cell. 10(6):1403-1415
Ikaros family members are important regulatory factors in lymphocyte development. Here we show that Ikaros may play an important role in CD4 versus CD8 lineage commitment decisions by demonstrating: (1) that it binds to regulatory elements in the end
Autor:
Arnd Hostert, Trisha Norton, Sandra Hirschberg, Anna Garefalaki, Mark Coles, Dimitris Kioussis, Georgia Mavria
Publikováno v:
Immunity. 16:635-647
The developmental and subset-specific expression of the CD8 genes is under the control of a complex array of regulatory elements distributed along the locus and characterized by DNaseI hypersensitivity. Here we describe the phenotype of mice in which
Autor:
Sarah E. R. Halford, Paul Jones, Steve Wedge, Sandra Hirschberg, Sidath Katugampola, Gareth Veal, Geoffrey Payne, Chris Bacon, Sarah Potter, Melanie Griffin, Maxime Chenard-Poirier, George Petrides, Graham Holder, Hector C Keun, Udai Banerji, Elizabeth R. Plummer
Publikováno v:
Journal of Clinical Oncology. 35:2516-2516
2516 Background: A key metabolic alteration in tumour cells is an increased dependency on the glycolysis, resulting in the production of lactate, which is transported out of cells by MCTs. Inhibition of MCT-1 leads to a profound inhibition of cancer
Autor:
Dennis L Sprecher, Ulf Riserus, Sandra Hirschberg, David Hassall, Eric J Olson, Lea Sarov-Blat, Stephen O’Rahilly, Timothy M Willson, Peter Murgatroyd, Anthony Johnson, Keith Frayn, Fredrik Karpe
Publikováno v:
Circulation. 116
Hypertriglyceridemia and insulin resistance in the setting of obesity, i.e. the metabolic syndrome, are thought related to ectopic fat storage and impaired regulation of fat oxidation. Rodent models suggest that increased PPARdelta function may corre
Autor:
Romain Pauwels, Sandra Hirschberg, Guy Joos, Charles Fogarty, Isidore Faiferman, Rupert Vessey, Emiel F.M. Wouters
Publikováno v:
Pulmonary Pharmacology & Therapeutics, 21(2), 385-392. Academic Press Inc.
The objectives of this study were to determine the effect of single and repeat dosing with oral ondansetron, a 5-HT3-specific receptor blocker, on the degree and duration of bronchodilation induced by inhaled ipratropium bromide in patients with COPD