Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Sandra Heskamp"'
Autor:
Anne P. M. Beerkens, Daan F. Boreel, James A. Nathan, Jiri Neuzil, Gang Cheng, Balaraman Kalyanaraman, Micael Hardy, Gosse J. Adema, Sandra Heskamp, Paul N. Span, Johan Bussink
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-10 (2024)
Abstract Background Hypoxia is a common feature of many solid tumors and causes radiotherapy and immunotherapy resistance. Pharmacological inhibition of oxidative phosphorylation (OXPHOS) has emerged as a therapeutic strategy to reduce hypoxia. Howev
Externí odkaz:
https://doaj.org/article/6158a99077a34dd2a03b9ab6923fa43f
Autor:
Jim Middelburg, Marjolein Sluijter, Gaby Schaap, Büşra Göynük, Katy Lloyd, Vitalijs Ovcinnikovs, Gijs G. Zom, Renoud J. Marijnissen, Christianne Groeneveldt, Lisa Griffioen, Gerwin G. W. Sandker, Sandra Heskamp, Sjoerd H. van der Burg, Tsolere Arakelian, Ferry Ossendorp, Ramon Arens, Janine Schuurman, Kristel Kemper, Thorbald van Hall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract CD3 bispecific antibody (CD3 bsAb) therapy is clinically approved for refractory hematological malignancies, but responses in solid tumors have been limited so far. One of the main hurdles in solid tumors is the lack of sufficient T-cell inf
Externí odkaz:
https://doaj.org/article/36795cab2cda485e96053669065dc63a
Autor:
Milou Boswinkel, René Raavé, Andor Veltien, Tom WJ Scheenen, Nina Fransén Petterson, René in ‘t Zandt, Lars E. Olsson, Karin von Wachenfeldt, Sandra Heskamp, Irma Mahmutovic Persson
Publikováno v:
Frontiers in Nuclear Medicine, Vol 3 (2023)
ObjectiveAccurate imaging biomarkers that indicate disease progression at an early stage are highly important to enable timely mitigation of symptoms in progressive lung disease. In this context, reproducible experimental models and readouts are key.
Externí odkaz:
https://doaj.org/article/a405629d6a6940eca5062731026e2424
Autor:
Thorbald van Hall, Jim Middelburg, Gerwin Gerhard Wemke Sandker, Evienne Wilbrink, Janneke Molkenboer-Kuenen, Erik Aarntzen, Sandra Heskamp
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background CD3 bispecific antibodies (CD3-bsAbs) require binding of both a tumor-associated surface antigen and CD3 for their immunotherapeutic effect. Their efficacy is, therefore, influenced by the tumor uptake and the extracellular dose. To optimi
Externí odkaz:
https://doaj.org/article/a20cb64dfac3462d8468563a33246239
Autor:
Iris M. Hagemans, Peter J. Wierstra, Kas Steuten, Janneke D. M. Molkenboer-Kuenen, Duco van Dalen, Martin ter Beest, Johan M. S. van der Schoot, Olga Ilina, Martin Gotthardt, Carl G. Figdor, Ferenc A. Scheeren, Sandra Heskamp, Martijn Verdoes
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background While immune checkpoint inhibitors such as anti-PD-L1 antibodies have revolutionized cancer treatment, only subgroups of patients show durable responses. Insight in the relation between clinical response, PD-L1 expression and intr
Externí odkaz:
https://doaj.org/article/bce30ec5271e44dfb6d7dc4a81599ac1
Autor:
Iris M. Hagemans, Peter J. Wierstra, Kas Steuten, Janneke D. M. Molkenboer-Kuenen, Duco van Dalen, Martin ter Beest, Johan M. S. van der Schoot, Olga Ilina, Martin Gotthardt, Carl G. Figdor, Ferenc A. Scheeren, Sandra Heskamp, Martijn Verdoes
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/145df4837af84e51a6fd6145a71f73f9
Autor:
Fokko J. Huizing, Bianca A.W. Hoeben, Jasper Lok, Otto C. Boerman, Sandra Heskamp, Johan Bussink
Publikováno v:
Physics and Imaging in Radiation Oncology, Vol 19, Iss , Pp 145-150 (2021)
Background and purpose: Tumor hypoxia is an important cause of radioresistance and is associated with poor outcome.SPECT (Single-photon emission computed tomography) imaging enables visualizing tumor characteristics. We investigated the SPECT-radiotr
Externí odkaz:
https://doaj.org/article/dd2fd80f825e474d993f5860a5309827
Autor:
Gerwin G. W. Sandker, Gosse Adema, Janneke Molkenboer-Kuenen, Peter Wierstra, Johan Bussink, Sandra Heskamp, Erik H. J. G. Aarntzen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundProgrammed death-ligand 1 (PD-L1) regulates immune homeostasis by promoting T-cell exhaustion. It is involved in chronic infections and tumor progression. Nuclear imaging using radiolabeled anti-PD-L1 antibodies can monitor PD-L1 tissue exp
Externí odkaz:
https://doaj.org/article/785887c64a7e45628531f9d9e709f550
Autor:
Evelien A. J. van Genugten, Jetty A. M. Weijers, Sandra Heskamp, Manfred Kneilling, Michel M. van den Heuvel, Berber Piet, Johan Bussink, Lizza E. L. Hendriks, Erik H. J. G. Aarntzen
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Metabolic reprogramming is recognized as one of the hallmarks of cancer. Alterations in the micro-environmental metabolic characteristics are recognized as important tools for cancer cells to interact with the resident and infiltrating T-cells within
Externí odkaz:
https://doaj.org/article/9b66e4df3d91464b8a3b133634adb7fa
Autor:
Peter Wierstra, Gerwin Sandker, Erik Aarntzen, Martin Gotthardt, Gosse Adema, Johan Bussink, René Raavé, Sandra Heskamp
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 4, Iss 1, Pp 1-20 (2019)
Abstract Immunotherapy with checkpoint inhibitors demonstrates impressive improvements in the treatment of several types of cancer. Unfortunately, not all patients respond to therapy while severe immune-related adverse effects are prevalent. Currentl
Externí odkaz:
https://doaj.org/article/20f31596bfc0426dafc57c35de5ebd0a