Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sandra Heckers"'
Autor:
Stefan Gingele, Florian Henkel, Sandra Heckers, Thiemo M. Moellenkamp, Martin W. Hümmert, Thomas Skripuletz, Martin Stangel, Viktoria Gudi
Publikováno v:
Cells, Vol 9, Iss 4, p 945 (2020)
To unravel the failure of remyelination in multiple sclerosis (MS) and to test promising remyelinating treatments, suitable animal models like the well-established cuprizone model are required. However, this model is only standardized in young mice.
Externí odkaz:
https://doaj.org/article/34b9a707c0954209873c5b6215ab3f08
Autor:
Jessica Kronenberg, Kaweh Pars, Marina Brieskorn, Chittappen K. Prajeeth, Sandra Heckers, Philipp Schwenkenbecher, Thomas Skripuletz, Refik Pul, Andreas Pavlou, Martin Stangel
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 2, p 325 (2019)
Dimethylfumarate (DMF) has been approved the for treatment of relapsing-remitting multiple sclerosis. The mode of action of DMF and its assumed active primary metabolite monomethylfumarate (MMF) is still not fully understood, notably for brain reside
Externí odkaz:
https://doaj.org/article/ecf294d1a28c403da7c6c6896419544a
Autor:
Franco Corvace, Timo Jendrik Faustmann, Sandra Heckers, Pedro M. Faustmann, Fatme Seval Ismail
Publikováno v:
Pharmacology. 108:188-198
Introduction: Multiple sclerosis (MS) is the most common chronic inflammatory, demyelinating disease of the central nervous system. Dimethyl fumarate (DMF) and monomethyl fumarate (MMF) belong to the disease-modifying drugs in treatment of MS. There
Autor:
Thomas Skripuletz, Chittappen K. Prajeeth, Martin Stangel, Refik Pul, Sandra Heckers, Philipp Schwenkenbecher, Kaweh Pars, Marina Brieskorn, Andreas Pavlou, Jessica Kronenberg
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 2
International Journal of Molecular Sciences, Vol 20, Iss 2, p 325 (2019)
Volume 20
Issue 2
International Journal of Molecular Sciences, Vol 20, Iss 2, p 325 (2019)
Dimethylfumarate (DMF) has been approved the for treatment of relapsing-remitting multiple sclerosis. The mode of action of DMF and its assumed active primary metabolite monomethylfumarate (MMF) is still not fully understood, notably for brain reside
Autor:
Lukas Merkel, Martin Stangel, H. Markus Schwab, Sandra Heckers, Jessica Kronenberg, Viktoria Gudi
Publikováno v:
Journal of molecular neuroscience : MN. 67(3)
Growth factors play a crucial role during de- and remyelination of the central nervous system (CNS) due to their neurotrophic functions. We have previously shown that the growth factors neuregulin-1 (Nrg-1) and glial cell-derived neurotrophic factor
Autor:
Refik Pul, Katharina Stahl, Vikramjeet Singh, Chittappen K. Prajeeth, Martin Stangel, Thomas Skripuletz, Viktoria Gudi, Corinna Trebst, Stefanie Janßen, Georgios Tsiavaliaris, Sandra Heckers
Publikováno v:
Experimental Neurology. 261:666-676
Microglia are resident macrophages in the central nervous system (CNS) and the primary cells that contribute to CNS inflammation in many pathological conditions. Upon any signs of brain damage, microglia become activated and undergo tremendous cellul
Autor:
Markus H. Schwab, Lukas Merkel, Martin Stangel, Sandra Heckers, Jessica Kronenberg, Viktoria Gudi
Publikováno v:
Journal of Molecular Neuroscience. 68:318-318
The original version of this article unfortunately contained mistakes in the author group and affiliation sections. Author Markus H. Schwab's name was incorrectly presented as "H. Markus Schwab" and his affiliations were incorrectly assigned as "1 an
Autor:
Sandra Heckers, Nadine Held, André Bleich, Viktoria Gudi, Jessica Kronenberg, Martin Stangel, Thomas Skripuletz
Publikováno v:
Neurotoxicity research. 31(4)
Animal models, such as cuprizone (bis-cyclohexanone oxaldihydrazone) feeding, are helpful to study experimental demyelination and remyelination in the context of diseases like multiple sclerosis. Cuprizone is a copper chelator, which when supplemente
Low dose fumaric acid esters are effective in a mouse model of spontaneous chronic encephalomyelitis
Autor:
Anne-Kathrin Trampe, Ralf Gold, Andrew T. Chan, Sandra Heckers, Xiomara Pedreiturria, Seray Demir, Daniela Hess
Publikováno v:
Journal of neuroimmunology. 285
In this study we examined the role of fumaric acid esters (FAE) in a spontaneous and chronic animal model, the opticospinal EAE (OSE). Preventive treatment of dimethylfumarate (DMF) promotes onset of disease in animals treated with high dose DMF. Thi