Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sandra Hakim"'
Publikováno v:
AcTion: Aceh Nutrition Journal, Vol 8, Iss 4, Pp 660-665 (2023)
Antioxidants in ginger (Zingiber officinale) and sappan wood play roles in health benefits, including dilating blood vessels and inhibiting cancer cells. The study analyzes the differences in organoleptic characteristics and antioxidant activity of p
Externí odkaz:
https://doaj.org/article/ea3d2d4866e54b4ba5d12910ab883f6e
Autor:
Jennifer M Dyson, Absorn Sriratana, Monica N. Koenig, Sharon D. Ricardo, Sandra Hakim, Robin M. Hobbs, Ian M. Smyth, Elizabeth M Davies, Sandra J Feeney, Christina Anne Mitchell, Olga V. Plotnikova
Publikováno v:
Human Molecular Genetics. 25:2295-2313
Polycystic kidney disease (PKD) is a common cause of renal failure with few effective treatments. INPP5E is an inositol polyphosphate 5-phosphatase that dephosphorylates phosphoinositide 3-kinase (PI3K)-generated PI(3,4,5)P3 and is mutated in ciliopa
Autor:
Christina Anne Mitchell, Sandra J Feeney, Helen E. Abud, Sarah E Conduit, Lisa M Ooms, Jennifer M Dyson, Sandra Hakim
Publikováno v:
Human Molecular Genetics.
Polycystic kidney disease (PKD) results from excessive renal epithelial cell proliferation, leading to the formation of large fluid filled cysts which impair renal function and frequently lead to renal failure. Hyperactivation of numerous signaling p
Autor:
Rajendra Gurung, Kristy A. Horan, Alex J. Fulcher, Absorn Sriratana, Carol Wicking, Georg Ramm, Tia DiTommaso, Sandra Hakim, Ian M. Smyth, Sarah E Conduit, Sandra J Feeney, Christina Anne Mitchell, Jennifer M Dyson
Publikováno v:
The Journal of Cell Biology
Dyson et al. demonstrate that the inositol polyphosphate 5-phosphatase INPP5E is essential for Hedgehog-dependent embryonic development. By regulating PI(4,5)P2 and PI(3,4,5)P3 signals at cilia, INPP5E contributes to cilia transition zone function an
Autor:
Tony Tiganis, Ivan Ivetac, David A. Sheffield, Christina Anne Mitchell, Rajendra Gurung, Lauren C. Binge, Philip W. Majerus, Sandra Hakim, Kristy A. Horan
Publikováno v:
EMBO reports. 10:487-493
Akt is a crucial phosphoinositide 3-kinase (PI(3)K) effector that regulates cell proliferation and survival. PI(3)K-generated signals, PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2), direct Akt plasma membrane engagement. Pathological Akt plasma membrane asso
Autor:
Sandra Hakim, Jennifer M Dyson, Seongjin Seo, Denny L Cottle, Ian M. Smyth, Olga V. Plotnikova, Christina Anne Mitchell, Sarah E Conduit
Publikováno v:
Journal of cell science. 128(2)
Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) cause the ciliopathies known as Joubert and MORM syndromes; however, the role of INPP5E in ciliary biology is not well understood. Here, we describe an interaction between INPP5E and AURKA,
Publikováno v:
Current topics in microbiology and immunology. 362
Phosphoinositide signalling molecules interact with a plethora of effector proteins to regulate cell proliferation and survival, vesicular trafficking, metabolism, actin dynamics and many other cellular functions. The generation of specific phosphoin
Publikováno v:
Phosphoinositides and Disease ISBN: 9789400750241
Phosphoinositide signalling molecules interact with a plethora of effector proteins to regulate cell proliferation and survival, vesicular trafficking, metabolism, actin dynamics and many other cellular functions. The generation of specific phosphoin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a13dec5b58be388102e78c7c31858bb1
https://doi.org/10.1007/978-94-007-5025-8_12
https://doi.org/10.1007/978-94-007-5025-8_12