Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sandra Gunne"'
Autor:
Sandra Gunne, Marie Schwerdtner, Marina Henke, Ann-Kathrin Schneider, Lucas Keutmann, Eva Böttcher-Friebertshäuser, Susanne Schiffmann
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 419 (2023)
Background: The transmembrane protease serine 2 (TMPRSS2) proteolytically activates the envelope proteins of several viruses for viral entry via membrane fusion and is therefore an interesting and promising target for the development of broad-spectru
Externí odkaz:
https://doaj.org/article/5532d2cd24f8454f92e849bf52a24b47
Autor:
Susanne Schiffmann, Sandra Gunne, Thomas Ulshöfer, Marina Henke, Luise A. Roser, Ann-Kathrin Schneider, Jindrich Cinatl, Dominique Thomas, Yannick Schreiber, Pia Viktoria Wagner, Arnold Grünweller, Michael J. Parnham
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1086 (2022)
We characterized the in vitro safety and bioavailability profile of silvestrol, a compound effective against various viruses, such as corona- and Ebolaviruses, with an EC50 value of about 5 nM. The cytotoxic profile of silvestrol was assessed in vari
Externí odkaz:
https://doaj.org/article/b619ea0c7826480faf8049ba991d8de3
Autor:
Sandra Gunne, Ulrike Heinicke, Michael J. Parnham, Volker Laux, Kai Zacharowski, Andreas von Knethen
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1688 (2020)
The transcription factor NF-E2 p45-related factor 2 (Nrf2) is an established master regulator of the anti-oxidative and detoxifying cellular response. Thus, a role in inflammatory diseases associated with the generation of large amounts of reactive o
Externí odkaz:
https://doaj.org/article/316fa7eb89574b4f9e309b1fe3a1c4cf
Autor:
Dieter Steinhilber, Annette Sethmann, Michael J. Parnham, Marina Henke, Thomas Ulshöfer, Susanne Schiffmann, Sandra Gunne
Publikováno v:
Journal of Inflammation Research
Susanne Schiffmann,1,2 Sandra Gunne,1,2 Marina Henke,1 Thomas Ulshöfer,1 Dieter Steinhilber,1 Annette Sethmann,3 Michael J Parnham1 1Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Frankfurt am Main, 60596, Germany; 2Pharmaz
Autor:
Eugeny A. Ermilov, Annegret Preuß, Tilo Knape, Steffen Hackbarth, Tobias Bornhütter, Beate Röder, Michael Schindler, Laura Kuchler, Sandra Gunne, Bernhard Brüne, Verena Trümper, Lázló Ujlaky-Nagy, Michael J. Parnham, Andreas von Knethen, Anne Schäfer, György Vereb
Publikováno v:
Theranostics
PPARγ is a pharmacological target in inflammatory and metabolic diseases. Upon agonistic treatment or following antagonism, binding of co-factors is altered, which consequently affects PPARγ-dependent transactivation as well as its DNA-independent
Tolerizing CTL by sustained hepatic PD-L1 expression provides a new therapy spproach in mouse sepsis
Autor:
Bernhard Brüne, Andreas von Knethen, Andreas Weigert, Michael J. Parnham, Kerstin Abshagen, Florian R. Greten, Mateusz Putyrski, Brigitte M. Pützer, Laura Kuchler, Edith Hintermann, Beate Fißlthaler, Berit Genz, Lisa K. Sha, Tilo Knape, Shahzad N. Syed, Urs Christen, Anne Schäfer, Volkhard A. J. Kempf, Ajay M. Shah, Martin Schulz, Katrin Schröder, Andreas Ernst, Fabian Finkelmeier, Sandra Gunne, Michael Hogardt, Ralf P. Brandes, Marina Pesic
Publikováno v:
Theranostics
Cytotoxic T lymphocyte (CTL) activation contributes to liver damage during sepsis, but the mechanisms involved are largely unknown. Understanding the underlying principle will permit interference with CTL activation and thus, provide a new therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9a05ac1742a0a1c5c6a56543e3b0c1
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/49948
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/49948