Výsledky vyhledávání - "Sandra Gomez Lopez"

Asymmetric cell division of stem and progenitor cells during homeostasis and cancer

Autor: Sandra Gomez-Lopez, Claudia Petritsch, Robin G. Lerner

Publikováno v: Cellular and Molecular Life Sciences

Stem and progenitor cells are characterized by their ability to self-renew and produce differentiated progeny. A fine balance between these processes is achieved through controlled asymmetric divisions and is necessary to generate cellular diversity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74a22089569b2f640604855e9ddda9e
https://doi.org/10.1007/s00018-013-1386-1

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SC-14ASYMMETRY-DEFECTIVE OLIGODENDROCYTE PROGENITORS AS POTENTIAL CELL-OF-ORIGIN OF HYPERACTIVATED RAF-INDUCED MALIGNANT ASTROCYTOMAS

Autor: Sandra Gomez-Lopez, Robin G. Lerner, Maxim Sidorov, Banafsheh Kadkhodaei, David James, Martin McMahon, Claudia Petritsch

BACKGROUND: Studies show that the expression of an activating mutation of BRAF (BRAFV600E) in conjunction with Ink4a/Arf deletion, but not each alteration by itself, lead to formation of malignant astrocytoma (MA)-like tumors. Importantly, BRAFV600E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faac5f078bd90a4736750e78e925b9a6
https://europepmc.org/articles/PMC4218573/

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Abstract 1942: Lgl1 loss promotes stemness and invasion in EGFRvIII-driven gliomas

Autor: Sandra Gomez-Lopez, Robin G. Lerner, Claudia Petritsch

Publikováno v: Cancer Research. 74:1942-1942

Stem and progenitor cells may divide asymmetrically to self-renew and produce differentiating progeny in a single division. Usually, during an asymmetric cell division (ACD), determinants of self-renewal and differentiation segregate to opposite daug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::500fe1058569e09fba87e05956888105
https://doi.org/10.1158/1538-7445.am2014-1942

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