Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sandra Glasmacher"'
Autor:
Liad Hinden, Majdoleen Ahmad, Sharleen Hamad, Alina Nemirovski, Gergő Szanda, Sandra Glasmacher, Aviram Kogot-Levin, Rinat Abramovitch, Bernard Thorens, Jürg Gertsch, Gil Leibowitz, Joseph Tam
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Renal proximal tubules modulate whole-body homeostasis by sensing various nutrients. Here the authors describe the existence and importance of a unique CB1/mTORC1/GLUT2 signaling axis in regulating nutrient homeostasis in healthy and diseased kidney.
Externí odkaz:
https://doaj.org/article/fa78e76598394da191ce9a6dc515b56c
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 2784-2792 (2016)
The human pathogen Pseudomonas aeruginosa uses the pqs quorum sensing system to coordinate the production of its broad spectrum of virulence factors to facilitate colonization and infection of its host. Hereby, the enzyme PqsD is a virulence related
Externí odkaz:
https://doaj.org/article/ec317ec2145c4f0881fb35332eb29e16
Autor:
Liad Hinden, Majdoleen Ahmad, Sharleen Hamad, Alina Nemirovski, Sandra Glasmacher, Aviram Kogot-Levin, Jürg Gertsch, Gil Leibowitz, Joseph Tam
Publikováno v:
Nephrology Dialysis Transplantation. 37
BACKGROUND AND AIMS Diabetic kidney disease (DKD), the renal manifestation of diabetes, contributes to increased morbidity and mortality of patients with diabetes. Activation of the cannabinoid-1 receptor (CB1R) and the mammalian target of rapamycin
Autor:
Isabella Caligiuri, Vincenzo Canzonieri, Giulio Poli, Eleonora Gori, Tiziana Perin, Sandra Glasmacher, Andrea Chicca, Jürg Gertsch, Rebecca Ferrisi, Flavio Rizzolio, Filippo Minutolo, Giulia Mantini, Tiziano Tuccinardi, Giulia Bononi, Marco Macchia, Andrea Sodi, Elisa Giovannetti, Carlotta Granchi, Stefano Palazzolo
Publikováno v:
Granchi, C, Bononi, G, Ferrisi, R, Gori, E, Mantini, G, Glasmacher, S, Poli, G, Palazzolo, S, Caligiuri, I, Rizzolio, F, Canzonieri, V, Perin, T, Gertsch, J R, Sodi, A, Giovannetti, E, Macchia, M, Minutolo, F, Tuccinardi, T & Chicca, A 2021, ' Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors ', European Journal of Medicinal Chemistry, vol. 209, 112857 . https://doi.org/10.1016/j.ejmech.2020.112857
European Journal of Medicinal Chemistry, 209:112857. Elsevier Masson SAS
European Journal of Medicinal Chemistry, 209:112857. Elsevier Masson SAS
An interesting enzyme of the endocannabinoid system is monoacylglycerol lipase (MAGL). This enzyme, which metabolizes the endocannabinoid 2-arachidonoylglycerol (2-AG), has attracted great interest due to its involvement in several physiological and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac48e4d28188ea63f3b8262b96d6d7c
http://hdl.handle.net/11568/1104307
http://hdl.handle.net/11568/1104307
Autor:
Carl-Christian Kolbe, Este Leidmaa, Jürg Gertsch, Lena-Louise Schuele, Marie Denise Roggan, Beat Lutz, Andras Bilkei-Gorzo, Janis-Lisa Transfeld, Sandra Glasmacher, Andreas Zimmer, Laura Bindila
Publikováno v:
Schuele, Lena-Louise; Glasmacher, Sandra; Gertsch, Jürg; Roggan, Marie Denise; Transfeld, Janis-Lisa; Bindila, Laura; Lutz, Beat; Kolbe, Carl-Christian; Bilkei-Gorzo, Andras; Zimmer, Andreas; Leidmaa, Este (2021). Diacylglycerol lipase alpha in astrocytes is involved in maternal care and affective behaviors. GLIA, 69(2), pp. 377-391. Wiley 10.1002/glia.23903
Genetic deletion of cannabinoid CB1 receptors or diacylglycerol lipase alpha (DAGLa), the main enzyme involved in the synthesis of the endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG), produced profound phenotypes in animal models of depression-re
Autor:
Sandra Glasmacher, Jürg Gertsch
Publikováno v:
Glasmacher, Sandra; Gertsch, Jürg (2021). Characterization of pepcan-23 as pro-peptide of RVD-hemopressin (pepcan-12) and stability of hemopressins in mice. Advances in biological regulation, 80, p. 100808. Elsevier 10.1016/j.jbior.2021.100808
Hemopressins ((x)-PVNFKLLSH) or peptide endocannabinoids (pepcans) can bind to cannabinoid receptors. RVD-hemopressin (pepcan-12) was shown to act as endogenous allosteric modulator of cannabinoid receptors, with opposite effects on CB1 and CB2, resp
Autor:
Vanessa Petrucci, Zongxian Cao, Sandra Glasmacher, Andrea Chicca, Jürg Gertsch, Pal Pacher, János Pálóczi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Petrucci, Vanessa; Chicca, Andrea; Glasmacher, Sandra Patricia; Paloczi, Janos; Cao, Zongxian; Pacher, Pal; Gertsch, Jürg (2017). Pepcan-12 (RVD-hemopressin) is a CB2 receptor positive allosteric modulator constitutively secreted by adrenals and in liver upon tissue damage. Scientific Reports, 7(1), p. 9560. Nature Publishing Group 10.1038/s41598-017-09808-8
Scientific Reports
Petrucci, Vanessa; Chicca, Andrea; Glasmacher, Sandra Patricia; Paloczi, Janos; Cao, Zongxian; Pacher, Pal; Gertsch, Jürg (2017). Pepcan-12 (RVD-hemopressin) is a CB2 receptor positive allosteric modulator constitutively secreted by adrenals and in liver upon tissue damage. Scientific Reports, 7(1), p. 9560. Nature Publishing Group 10.1038/s41598-017-09808-8
Pepcan-12 (RVD-hemopressin; RVDPVNFKLLSH) is the major peptide of a family of endogenous peptide endocannabinoids (pepcans) shown to act as negative allosteric modulators (NAM) of cannabinoid CB1 receptors. Noradrenergic neurons have been identified
Autor:
Margherita Lapillo, Isabella Caligiuri, Tiziano Tuccinardi, Marco Macchia, Andrea Chicca, Jürg Gertsch, Flavio Rizzolio, Filippo Minutolo, Giulia Bononi, Maguie El Boustani, Sandra Glasmacher, Carlotta Granchi, Giulio Poli, Cristina Licari
Monoacylglycerol lipase (MAGL) is the enzyme degrading the endocannabinoid 2-arachidonoylglycerol, and it is involved in several physiological and pathological processes. The therapeutic potential of MAGL is linked to several diseases, including canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653096d3b78d86ac59e28fe87ccbc41a
http://hdl.handle.net/10278/3711935
http://hdl.handle.net/10278/3711935
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 2784-2792 (2016)
The human pathogen Pseudomonas aeruginosa uses the pqs quorum sensing system to coordinate the production of its broad spectrum of virulence factors to facilitate colonization and infection of its host. Hereby, the enzyme PqsD is a virulence related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05db87743d6594f36c2deaee9d9a8169