Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sandra Gendler"'
Publikováno v:
Journal of Biological Chemistry. 271:2332-2340
The MUC1 gene product (PEM, polymorphic epithelial mucin) is a cell-associated glycoprotein expressed on the apical surface of most simple secretory epithelia. The transmembrane and cytoplasmic domains of MUC1 have been shown to be highly conserved b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3624f87bc7d82b19965fe4f24be0cc7
https://doi.org/10.1074/jbc.271.4.2332
https://doi.org/10.1074/jbc.271.4.2332
Autor:
Sandra Gendler, P. Michael Conneally, Hope H. Punnett, Marcia M. Shull, Joop Wiegant, Jeff Hall, Orest Hurko, Lee A. Anderson, Norman Latov, Thomas D. Bird, Robert E. Lovelace, Phillip F. Chance, James A. Trofatter, Mary Claire King, Steven A. Schonberg, Mitchell S. Golbus, Peter J. Dyck, Paul Dazin, Zharong Jiang, Ma. Theresa Redila-Flores, Roger V. Lebo, Kevin W. Moore, Eric Lynch
Publikováno v:
Human Genetics. 88:1-12
The Charcot-Marie-Tooth disease (hereditary motor and sensory neuropathy) loci have been reported to be on at least three chromosomes: 1 (CMT1B, HMSN1B), 17 (CMT1A), and X (CMTX). In this study multipoint linkage analysis of two Duffy-linked families
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96fe222eae3cc87599a7c6bfcd49ce60
https://doi.org/10.1007/bf00204921
https://doi.org/10.1007/bf00204921
Autor:
Trevor Duhig, Sandra Gendler, Nigel Peat, David Wilson, Joyce Taylor-Papadimitriou, Carole A. Lancaster
Publikováno v:
Biochemical and Biophysical Research Communications. 173:1019-1029
The human polymorphic epithelial mucin (PEM) is expressed apically by glandular epithelium and by the carcinomas that develop from these tissues. Previously isolated cDNA clones revealed that the core protein contained a large domain consisting of va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58757584c7707142f4c6f1a5c096bc8
https://doi.org/10.1016/s0006-291x(05)80888-5
https://doi.org/10.1016/s0006-291x(05)80888-5
Publikováno v:
The Journal of Immunology. 190:132.17-132.17
Recent guidelines by the American Society of Clinical Oncologists recommend that obese individuals receive chemotherapy based on their actual body weight (ABW) without dose reduction. Contrary to prior reports, our own data demonstrate that ABW-dosed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d64a59ec49645c6056ca51c6c006ac3c
https://doi.org/10.4049/jimmunol.190.supp.132.17
https://doi.org/10.4049/jimmunol.190.supp.132.17
Autor:
Soraya Zorro Manrique, Christopher Spencer, Ana Dominguez, Judy Bradley, Noweeda Mirza, Jennifer Ko, Carole Viso, Naomi Gades, James Finke, Larry Pease, Sandra Gendler, Peter Cohen
Publikováno v:
The Journal of Immunology. 190:132.21-132.21
4T1 is a metastatic breast cancer model with fulminant accumulation of MDSCs. Survival and function of MDSCs is often reported as STAT3-dependent, and STAT3 inhibitors such as sunitinib dramatically deplete 4T1 splenic MDSCs. Paradoxically, sunitinib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3745c2e5af2c8000a03101ba3470d30
https://doi.org/10.4049/jimmunol.190.supp.132.21
https://doi.org/10.4049/jimmunol.190.supp.132.21
Autor:
Peter Cohen, Latha Pathangey, Dustin McCurry, Jessica Gorman, Carole Viso, Sandra Gendler, Mary Disis
Publikováno v:
The Journal of Immunology. 190:205.19-205.19
Although tumors from melanoma patients can often provide a source of therapeutically active T cells for adoptive therapy, it has historically proved challenging to employ peripheral blood as the T cell source for any type of cancer. We have observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::530d0cb8f29a78b69a42515bdb9b000f
https://doi.org/10.4049/jimmunol.190.supp.205.19
https://doi.org/10.4049/jimmunol.190.supp.205.19
Autor:
Dominique Hoelzinger, Ana Dominguez, Kevin Pollock, Joseph Lustgarten, Peter Cohen, Sandra Gendler
Publikováno v:
The Journal of Immunology. 190:140.9-140.9
IL-9 is a cytokine that is primarily associated with mast cells and airway inflammation, however it also plays a role in T regulatory cell (Treg) survival and recruitment to tumors. We previously reported that 4-1BB treatment of Tregs inhibits both T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3062fb3842a4420a6590e703368ed705
https://doi.org/10.4049/jimmunol.190.supp.140.9
https://doi.org/10.4049/jimmunol.190.supp.140.9
Publikováno v:
The Journal of Immunology. 190:53.25-53.25
We demonstrate that a membrane-tethered epithelial mucin, Muc1 affects the differentiation of immature myeloid derived cells (IMCs) in the bone marrow (BM). First, in wild-type (WT) mice, BM-derived Lin-Sca1+ hematopoietic progenitor cells (HPCs) exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f7a1120de1deb8bd9a370ec5588424b
https://doi.org/10.4049/jimmunol.190.supp.53.25
https://doi.org/10.4049/jimmunol.190.supp.53.25
Aging subverts immune function by dictating alternative STAT responses to cytokine signaling (P5078)
Autor:
Noweeda Mirza, Soraya Zorro Manrique, Skylar Cohen, Ana Dominguez, Peter Cohen, Sandra Gendler
Publikováno v:
The Journal of Immunology. 190:180.22-180.22
Chronic inflammation in the aged closely resembles tumor-induced immune suppression, manifested as a progressive T1→T2 shift and an increased presence of MDSCs. We hypothesize that reversing these age-related phenomena should reduce the elderly’s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8544b16846ff9bfd3995b04de6ddc1b0
https://doi.org/10.4049/jimmunol.190.supp.180.22
https://doi.org/10.4049/jimmunol.190.supp.180.22
Autor:
Noweeda Mirza, Dominique Hoelzinger, Cheryl Myers, Kevin Pollock, Ana Dominguez, Joseph Lustgarten, Peter Cohen, Sandra Gendler
Publikováno v:
The Journal of Immunology. 188:54.4-54.4
Chronic inflammation associated with aging is termed inflamm-aging. It manifests as a rise in many proinflammatory mediators and contributes to a decline in immune function. Unregulated inflammasome activation initiates an inappropriate inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::968949cbc3f83f1f0eb0ba776868e8ac
https://doi.org/10.4049/jimmunol.188.supp.54.4
https://doi.org/10.4049/jimmunol.188.supp.54.4