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pro vyhledávání: '"Sandra Gail Evans"'
Autor:
Ivan Havlik, Sandra Gail Evans
Publikováno v:
Transactions of the Royal Society of Tropical Medicine and Hygiene. 88:683-686
The interactions of amantadine with classical antimalarial drugs were evaluated against a chloriquine-resistant and a chloroquine-sensitive strain of Plasmodium falciparum in vitro. Amantadine potentiated the effect of chloroquine and quinine in both
Publikováno v:
Transactions of the Royal Society of Tropical Medicine and Hygiene. 92:87-89
Sulphated glycoconjugates have been reported to inhibit malarial merozoite invasion and interfere with rosetting and adhesion. Curdlan sulphate, a sulphated glycoconjugate with a favourable toxicity profile, exhibits antimalarial activity in vitro. T
Autor:
Ivan Havlik, Sandra Gail Evans
Publikováno v:
The American journal of tropical medicine and hygiene. 54(3)
Amantadine is a monoprotic weak base that inhibits intraerythrocytic growth in in vitro cultures of Plasmodium falciparum, specifically chloroquine-resistant strains. Changes in the external PH of the medium are expected to result in a shift in the r
Autor:
Sandra Gail Evans, Ivan Havlik
Publikováno v:
Biochemical pharmacology. 45(5)
The lysosomotropic nature of amantadine suggested potential as an antimalarial. Sensitivity tests to amantadine hydrochloride alone and in combination with chloroquine were carried out in 96-well microtitre plates using the tritiated hypoxanthine upt