Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sandra G. McLaren"'
Evaluation of dynamic [18F]-FDG-PET imaging for the detection of acute post-surgical bone infection.
Autor:
Tracy L Y Brown, Horace J Spencer, Karen E Beenken, Terri L Alpe, Twyla B Bartel, William Bellamy, J Michael Gruenwald, Robert A Skinner, Sandra G McLaren, Mark S Smeltzer
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41863 (2012)
Diagnosing bone infection in its acute early stage is of utmost clinical importance as the failure to do so results in a therapeutically recalcitrant chronic infection that can only be resolved with extensive surgical intervention, the end result oft
Externí odkaz:
https://doaj.org/article/c38cd7ecf7a4421a924091e0bfa26746
Autor:
Karen E. Beenken, Robert A. Skinner, Jessica A. Jennings, Warren O. Haggard, Horace J. Spencer, Mark S. Smeltzer, William T. Bellamy, James Keaton Smith, M. Johannes Gruenwald, Sandra G. McLaren
Publikováno v:
Journal of Biomaterials Applications. 29:514-523
We demonstrate that coating calcium sulfate with deacetylated chitosan enhances the elution profile of daptomycin by prolonging the period during which high concentrations of antibiotic are released. Coatings reduced initial bolus release of daptomyc
Publikováno v:
Clinical Orthopaedics & Related Research. 461:64-67
Particulate soluble filler added to polymethylmethacrylate increases its permeability, leading to increased elution. We asked whether particle size affects permeability and elution rate associated with a given volume fraction of filler. Permeability
Autor:
Dong, Sun, Michael, McCarthy, Adam C, Dooley, Raghu H, Ramakrishnaiah, R Shane, Shelton, Sandra G, McLaren, Robert A, Skinner, Larry J, Suva, Richard E, McCarthy
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 35(1)
Current convex tethering techniques for treatment of scoliosis have centered on anterior convex staples or polypropylene tethers. We hypothesized that an allograft tendon tether inserted via the costo-transverse foramen would correct an established s
Autor:
Carl L. Nelson, Larry J. Suva, J. Roby Thomas, Ronald C. Walker, Mark S. Smeltzer, Sandra G. McLaren, Ernest J. Ferris, Laurie Jones-Jackson, Robert A. Skinner, Gary L. Purnell, Marisa H. Miceli, Elias Anaissie
Publikováno v:
Journal of Orthopaedic Research. 23:1484-1489
Diagnosing bone infection in the context of post-surgical inflammation is problematic since many of the early signs of infection are similar to normal post-surgical changes. We used a rabbit osteomyelitis model to evaluate the use of 2-deoxy-2-[18F]-
Publikováno v:
Clinical Orthopaedics and Related Research. :25-30
Surgeons who treat osteomyelitis or infected implants think that microorganisms can live on and around implanted biomaterials and necrotic bone without clinical manifestations of infection. Gristina and Costerton, in their seminal work, suggested tha
Publikováno v:
Clinical Orthopaedics and Related Research. 414:65-68
The purpose of this study was to determine whether the practice of surgical hand scrubbing among orthopaedic surgeons, faculty, residents, and nurses met the institution's recommended 5-minute scrub policy and how often a 2-minute surgical hand scrub
Publikováno v:
Clinical Orthopaedics and Related Research. 403:54-57
Release rate is a critical property of all drug delivery vehicles, including antibiotic-laden bioerodibles. In vitro elution studies, used to evaluate release rates, use different sampling methods, including changing the entire amount of buffer and p
Autor:
Larry L. Nguyen, Sandra G. McLaren, David L. Wassell, Carl L. Nelson, Michael Saccente, Mark S. Smeltzer
Publikováno v:
Clinical Orthopaedics and Related Research. 403:29-37
Glycocalyx-producing bacteria have been observed on orthopaedic devices that were removed for reasons other than infection. It has been suggested that the bacteria adhere to foreign surfaces within a biofilm and elude standard culture techniques. The
Autor:
J. Roby Thomas, Robert A. Skinner, Keith M. Olsen, Carl L. Nelson, Mark S. Smeltzer, Sandra G. McLaren
Publikováno v:
Journal of Orthopaedic Research. 20:643-647
Calcium sulfate was used as a biodegradable delivery system for the administration of antibiotics in musculoskeletal infection. New Zealand white rabbits were infected with Staplylococcus aureus, debrided, and randomized to one of four treatment grou