Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Sandra G Heil"'
Epigenome wide association study of response to methotrexate in early rheumatoid arthritis patients.
Autor:
Helen R Gosselt, Costanza L Vallerga, Pooja R Mandaviya, Erik Lubberts, Johanna M W Hazes, Robert de Jonge, Sandra G Heil
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0247709 (2021)
AimTo identify differentially methylated positions (DMPs) and regions (DMRs) that predict response to Methotrexate (MTX) in early rheumatoid arthritis (RA) patients.Materials and methodsDNA from baseline peripheral blood mononuclear cells was extract
Externí odkaz:
https://doaj.org/article/736434ab899447cabb519e42f9e12903
Autor:
Natanja Oosterom, Robert de Jonge, Desiree E C Smith, Rob Pieters, Wim J E Tissing, Marta Fiocco, Bertrand D van Zelst, Marry M van den Heuvel-Eibrink, Sandra G Heil
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221591 (2019)
BackgroundMethotrexate (MTX) is an important anti-folate agent in pediatric acute lymphoblastic leukemia (ALL) treatment. Folinic acid rescue therapy (Leucovorin) is administered after MTX to reduce toxicity. Previous studies hypothesized that Leucov
Externí odkaz:
https://doaj.org/article/c5f9c4f6e20e4367a49b88df7fd4d397
Autor:
Sandra G Heil, Emilie M Herzog, Pieter H Griffioen, Bertrand van Zelst, Sten P Willemsen, Yolanda B de Rijke, Regine P M Steegers-Theunissen, Eric A P Steegers
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226969 (2019)
IntroductionThe pathophysiology of preeclampsia is largely unknown. Serum placental induced growth factor (PlGF) levels are decreased during second trimester pregnancy. Aberrant DNA methylation is suggested to be involved in the etiology of preeclamp
Externí odkaz:
https://doaj.org/article/297c506e5fd242ddb78803be2212945d
Autor:
Natanja Oosterom, Pieter H Griffioen, Marissa A H den Hoed, Rob Pieters, Robert de Jonge, Wim J E Tissing, Marry M van den Heuvel-Eibrink, Sandra G Heil
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199574 (2018)
BACKGROUND:Children with acute lymphoblastic leukemia (ALL) often suffer from toxicity of chemotherapeutic drugs such as Methotrexate (MTX). Previously, we reported that 20% of patients receiving high-dose MTX developed oral mucositis. MTX inhibits f
Externí odkaz:
https://doaj.org/article/436c64c86ccf458d979c75358d09a3c1
Autor:
Pooja R Mandaviya, Roby Joehanes, Dylan Aïssi, Brigitte Kühnel, Riccardo E Marioni, Vinh Truong, Lisette Stolk, Marian Beekman, Marc Jan Bonder, Lude Franke, Christian Gieger, Tianxiao Huan, M Arfan Ikram, Sonja Kunze, Liming Liang, Jan Lindemans, Chunyu Liu, Allan F McRae, Michael M Mendelson, Martina Müller-Nurasyid, Annette Peters, P Eline Slagboom, John M Starr, David-Alexandre Trégouët, André G Uitterlinden, Marleen M J van Greevenbroek, Diana van Heemst, Maarten van Iterson, Philip S Wells, Chen Yao, Ian J Deary, France Gagnon, Bastiaan T Heijmans, Daniel Levy, Pierre-Emmanuel Morange, Melanie Waldenberger, Sandra G Heil, Joyce B J van Meurs, CHARGE Consortium Epigenetics group and BIOS Consortium
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0182472 (2017)
BACKGROUND:DNA methylation is affected by the activities of the key enzymes and intermediate metabolites of the one-carbon pathway, one of which involves homocysteine. We investigated the effect of the well-known genetic variant associated with mildl
Externí odkaz:
https://doaj.org/article/a894904b6bef47d19d0b9de51287e06e
Autor:
Giulietta S. Monasso, Thanh T. Hoang, Giulia Mancano, Sílvia Fernández-Barrés, John Dou, Vincent W.V. Jaddoe, Christian M. Page, Laura Johnson, Mariona Bustamante, Kelly M. Bakulski, Siri E. Håberg, Per M. Ueland, Thomas Battram, Simon K. Merid, Erik Melén, Doretta Caramaschi, Leanne K. Küpers, Jordi Sunyer, Wenche Nystad, Sandra G. Heil, Rebecca J. Schmidt, Martine Vrijheid, Gemma C. Sharp, Stephanie J. London, Janine F. Felix
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Circulating vitamin B12 concentrations during pregnancy are associated with offspring health. Foetal DNA methylation changes could underlie these associations. Within the Pregnancy And Childhood Epigenetics Consortium, we meta-analysed epigenome-wide
Externí odkaz:
https://doaj.org/article/e080ef2c12ef4dcea3bef66544558f52
Autor:
Helen R. Gosselt, Pieter H. Griffioen, Bertrand D. van Zelst, Natanja Oosterom, Robert de Jonge, Sandra G. Heil
Publikováno v:
Epigenetics, Vol 16, Iss 1, Pp 45-53 (2021)
Background: Epigenetic markers are often quantified and related to disease in stored samples. While, effects of storage on stability of these markers have not been thoroughly examined. In this longitudinal study, we investigated the influence of stor
Externí odkaz:
https://doaj.org/article/ee25caab32914f6885619b8238933cdd
Autor:
Sjoerd N. Duim, L. Tom Vlasveld, Stephanie T.P. Mezger, Alma M.A. Mingels, Christian R.B. Ramakers, Douwe de Boer, Sandra G. Heil, Ebba Nexo, André P. van Rossum
Publikováno v:
Annals of Clinical Biochemistry, 59(4), 302-307. SAGE Publications Ltd
Annals of Clinical Biochemistry, 59(4):00045632221087132, 302-307. SAGE Publications Inc.
Duim, S N, Vlasveld, L T, Mezger, S T P, Mingels, A M A, Ramakers, C R B, de Boer, D, Heil, S G, Nexo, E & van Rossum, A P 2022, ' “Macro transcobalamin causing raised vitamin B12 : Case-based laboratory investigation" ', Annals of Clinical Biochemistry, vol. 59, no. 4, pp. 302-307 . https://doi.org/10.1177/00045632221087132
Annals of Clinical Biochemistry, 59(4):00045632221087132, 302-307. SAGE Publications Inc.
Duim, S N, Vlasveld, L T, Mezger, S T P, Mingels, A M A, Ramakers, C R B, de Boer, D, Heil, S G, Nexo, E & van Rossum, A P 2022, ' “Macro transcobalamin causing raised vitamin B12 : Case-based laboratory investigation" ', Annals of Clinical Biochemistry, vol. 59, no. 4, pp. 302-307 . https://doi.org/10.1177/00045632221087132
Determination of plasma vitamin B12 (B12) is a frequently requested laboratory analysis, mainly employed to establish B12 deficiency. However, an increased level of B12 is a common unexpected finding that may be related to an increased concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d83349e7c45166a69ceb4879bc7a21
http://www.scopus.com/inward/record.url?scp=85130012797&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85130012797&partnerID=8YFLogxK
Autor:
Madelon L. Geurtsen, Janine F. Felix, Vincent W. V. Jaddoe, Giulietta S Monasso, Susana Santos, Sandra G. Heil
Publikováno v:
The Journal of Nutrition
Journal of Nutrition, 151(6), 1628-1636. American Society for Nutrition
Journal of Nutrition, 151(6), 1628-1636. American Society for Nutrition
Background: Higher circulating folate and vitamin B-12 concentrations and lower circulating homocysteine concentrations during pregnancy seem to be associated with fetal development. These micronutrients may also be associated with cardiometabolic he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822e167304319ab98bfc3ff134ef409e
https://doi.org/10.1093/jn/nxab039
https://doi.org/10.1093/jn/nxab039
Autor:
Sean Gullette, Rita Castro, Thomas Neuberger, Cristina Florindo, Sandra G. Heil, Floyd J. Mattie, Courtney Whalen, Neil K. Huang, A. Catharine Ross
Publikováno v:
Nutrients, Vol 13, Iss 3576, p 3576 (2021)
Nutrients
Volume 13
Issue 10
Nutrients, 13(10):3576. Multidisciplinary Digital Publishing Institute (MDPI)
Nutrients
Volume 13
Issue 10
Nutrients, 13(10):3576. Multidisciplinary Digital Publishing Institute (MDPI)
Hyperhomocysteneinemia (HHcy) is common in the general population and is a risk factor for atherosclerosis by mechanisms that are still elusive. A hypomethylated status of epigenetically relevant targets may contribute to the vascular toxicity associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d999c372677777a103f8d8e3adf86d
https://www.mdpi.com/2072-6643/13/10/3576
https://www.mdpi.com/2072-6643/13/10/3576