Tig1 regulates proximo-distal identity during salamander limb regeneration

Autor: Catarina R. Oliveira, Dunja Knapp, Ahmed Elewa, Tobias Gerber, Sandra G. Gonzalez Malagon, Phillip B. Gates, Hannah E. Walters, Andreas Petzold, Hernan Arce, Rodrigo C. Cordoba, Elaiyaraja Subramanian, Osvaldo Chara, Elly M. Tanaka, András Simon, Maximina H. Yun

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

The mechanisms by which cells determine their position within the 3D space are poorly understood. Research in salamanders offers fresh insights into this question, uncovering Tig1 as a central determinant of proximo-distal identity in regeneration.

Externí odkaz: https://doaj.org/article/a28a56187f184641a6673eeccce239c0

Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus

Autor: Sandra G. Gonzalez Malagon, Anna M. Lopez Muñoz, Daniel Doro, Triòna G. Bolger, Evon Poon, Elizabeth R. Tucker, Hadeel Adel Al-Lami, Matthias Krause, Christopher J. Phiel, Louis Chesler, Karen J. Liu

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Defects in neural crest development cause neurocristopathies and cancer, but what regulates this is unclear. Here, the authors show that glycogen synthase kinase 3 (GSK3) regulates migration of neural crest cells, as shown on genetic deletion of GSK3

Externí odkaz: https://doaj.org/article/e4c7c11b83d34ab0a2deda0f04ee42da

Tig1 regulates proximo-distal identity during salamander limb regeneration

Autor: Catarina R, Oliveira, Dunja, Knapp, Ahmed, Elewa, Tobias, Gerber, Sandra G, Gonzalez Malagon, Phillip B, Gates, Hannah E, Walters, Andreas, Petzold, Hernan, Arce, Rodrigo C, Cordoba, Elaiyaraja, Subramanian, Osvaldo, Chara, Elly M, Tanaka, András, Simon, Maximina H, Yun

Publikováno v: Nature communications. 13(1)

Salamander limb regeneration is an accurate process which gives rise exclusively to the missing structures, irrespective of the amputation level. This suggests that cells in the stump have an awareness of their spatial location, a property termed pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0293d9a99323c6e202f1223178d681cf
https://pubmed.ncbi.nlm.nih.gov/35922435

Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration

Autor: Karen J. Liu, Lisa Dobson, Petros Marangos, William B. Barrell, Matthias Krause, Sandra G. Gonzalez Malagon, Anna M. Lopez Muñoz, Marcus Dawson

Publikováno v: Journal of visualized experiments : JoVE

Over the past several decades there has been an increased availability of genetically modified mouse models used to mimic human pathologies. However, the ability to study cell movements and differentiation in vivo is still very difficult. Neurocristo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed20b79ad3a2a8aac616fd2563c6437
https://doi.org/10.3791/60051

ALK and GSK3:shared features of neuroblastoma and neural crest cells

Autor: Karen J. Liu, Sandra G. Gonzalez Malagon

Publikováno v: Gonzalez Malagon, S G & Liu, K J 2018, ' ALK and GSK3 : shared features of neuroblastoma and neural crest cells ', Journal of Experimental Neuroscience, vol. 12 . https://doi.org/10.1177/1179069518792499
Journal of Experimental Neuroscience, Vol 12 (2018)
Journal of Experimental Neuroscience

Neuroblastoma is one of the most common and deadly childhood cancers. Neuroblastoma arises from transformed cells of the neural crest lineage. Outcomes of the disease vary greatly, ranging from spontaneous regression to aggressive metastases. While t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c828e9afd492c9ce5018dedd7d159a7
https://kclpure.kcl.ac.uk/ws/files/98663234/JEXPNEUR2018_FinalSubmission.pdf