Výsledky vyhledávání - "Sandra Fontanière"

Akademický článek

Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases

Autor: Jean-Baptiste Renaud, Charlotte Boix, Marine Charpentier, Anne De Cian, Julien Cochennec, Evelyne Duvernois-Berthet, Loïc Perrouault, Laurent Tesson, Joanne Edouard, Reynald Thinard, Yacine Cherifi, Séverine Menoret, Sandra Fontanière, Noémie de Crozé, Alexandre Fraichard, Frédéric Sohm, Ignacio Anegon, Jean-Paul Concordet, Carine Giovannangeli

Publikováno v: Cell Reports, Vol 14, Iss 9, Pp 2263-2272 (2016)

Genome editing has now been reported in many systems using TALEN and CRISPR-Cas9 nucleases. Precise mutations can be introduced during homology-directed repair with donor DNA carrying the wanted sequence edit, but efficiency is usually lower than for

Externí odkaz: https://doaj.org/article/9e72daf905044cdabb15827d401b0355

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Generation of Rag1 ‐knockout immunodeficient rats and mice using engineered meganucleases

Autor: Alexandre Fraichard, Sandra Fontanière, Laurent Tesson, Séverine Ménoret, Séverine Remy, Ignacio Anegon, Reynald Thinard, Laure-Hélène Ouisse, Claire Usal, Derek Jantz

Publikováno v: The FASEB Journal. 27:703-711

Despite the recent availability of gene-specific nucleases, such as zinc-finger nucleases (ZFNs) and transcription activator-like nucleases (TALENs), there is still a need for new tools to modify the genome of different species in an efficient, rapid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a232d4342fa70dccb5ef57fdad0ca0
https://doi.org/10.1096/fj.12-219907

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Deregulation of anti-Mullerian hormone/BMP and transforming growth factor- pathways in Leydig cell lesions developed in male heterozygous multiple endocrine neoplasia type 1 mutant mice

Autor: Séverine Mazaud Guittot, Sandra Fontanière, Alain Calender, Nader Hussein, Anne-Marie Morera, Nathalie di Clemente, Huguette Casse, Jieli Lu, Chang X. Zhang

Publikováno v: Endocrine-Related Cancer
Endocrine-Related Cancer, BioScientifica, 2008, 15 (1), pp. 217-27. ⟨10.1677/ERC-06-0046⟩

International audience; Multiple endocrine neoplasia type 1 (MEN1) results from the mutation of the predisposing gene, MEN1. Heterozygous Men1 mutant mice previously generated by several laboratories, including ours, mimic largely MEN1 pathology. Int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6663f7a483228b6087407961dd721d71
https://doi.org/10.1677/erc-06-0046

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Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins

Autor: Laurent Tesson, Jean-Paul Concordet, Alison Creneguy, Dominique Gauguier, Carine Giovannangeli, Yacine Cherifi, Alexandre Fraichard, Claire Usal, Reynald Thinard, Ignacio Anegon, Séverine Remy, Jean-Baptiste Boulé, Charlotte Boix, Anne De Cian, Tuan H. Nguyen, Lucas Brusselle, Sandra Fontanière, Séverine Ménoret

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2015, 5, pp.14410. ⟨10.1038/srep14410⟩
Scientific Reports, 2015, 5, pp.14410. ⟨10.1038/srep14410⟩
Scientific Reports, Nature Publishing Group, 2015, 5, pp.14410. 〈10.1038/srep14410〉

The generation of genetically-modified organisms has been revolutionized by the development of new genome editing technologies based on the use of gene-specific nucleases, such as meganucleases, ZFNs, TALENs and CRISPRs-Cas9 systems. The most rapid a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55f5d3103dfd1300e32189ab9fba715
https://hal.sorbonne-universite.fr/hal-01271745/file/srep14410.pdf

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Gene expression profiling in insulinomas of Men1 β-cell mutant mice reveals early genetic and epigenetic events involved in pancreatic β-cell tumorigenesis

Autor: Wierinckx A, Ivo Gut, Jieli Lu, Chang X. Zhang, Hussein N, Lachuer J, Busato F, Sandra Fontanière, Wang Zq, Jörg Tost

Publikováno v: Endocrine-Related Cancer. 13:1223-1236

Mutations of the MEN1 gene lead to the occurrence of multiple endocrine neoplasia type 1 (MEN1). To gain insights into the mechanisms of the tumorigenesis related to MEN1 inactivation, we have used mice in which the Men1 gene was specifically disrupt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9815ed218bacd62b945d7927dcafc9
https://doi.org/10.1677/erc.1.01294

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Reduction of Menin Expression Enhances Cell Proliferation and Is Tumorigenic in Intestinal Epithelial Cells

Autor: Christine Bernard, Jean Alain Chayvialle, Martine Blanc, Sandra Fontanière, Alain Calender, Gilles Poncet, Christelle Ratineau, Claire Josso, Colette Roche, C.X. Zhang

Publikováno v: Journal of Biological Chemistry. 279:24477-24484

Menin, the product of the tumor suppressor gene MEN1, is widely expressed in mammalian endocrine and non-endocrine tissues, including intestine. Its known abundant expression in several types of cells with high proliferative capacity led us to invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2060a1c252f0331d5688b86cd28c22f4
https://doi.org/10.1074/jbc.m401835200

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Tumour suppressor menin is essential for development of the pancreatic endocrine cells

Autor: Chang-Xian Zhang, Raphaël Scharfmann, Christine Carreira, Bertrand Duvillié, Sandra Fontanière, Zhao-Qi Wang

Publikováno v: The Journal of endocrinology. 199(2)

Mutations of the multiple endocrine neoplasia type 1 (MEN1) gene predispose patients to MEN1 that affects mainly endocrine tissues, suggesting important physiological functions of the gene in adult endocrine cells. Homozygous disruption of Men1 in mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af71dc7d2ee57a7f497f8da3a5b1563d
https://pubmed.ncbi.nlm.nih.gov/18772165

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Comparison of nonsense-mediated mRNA decay efficiency in various murine tissues

Autor: Sylvie Mazoyer, Monique Buisson, Chang X Zhang, Delphine Magnin, Sandra Fontanière, Almoutassem B. Zetoune, Olga Anczuków

Publikováno v: BMC Genetics
BMC Genetics, BioMed Central, 2008, 9, pp.83. ⟨10.1186/1471-2156-9-83⟩
BMC Genetics, Vol 9, Iss 1, p 83 (2008)
BMC Genetics, 2008, 9, pp.83. ⟨10.1186/1471-2156-9-83⟩

Background The Nonsense-Mediated mRNA Decay (NMD) pathway detects and degrades mRNAs containing premature termination codons, thereby preventing the accumulation of potentially detrimental truncated proteins. Intertissue variation in the efficiency o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7b76caf4214f8c58ab2264a0279f76
https://hal-univ-lyon1.archives-ouvertes.fr/hal-02307235

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Reconstituted expression of menin in Men1-deficient mouse Leydig tumour cells induces cell cycle arrest and apoptosis

Autor: Philippe Bertolino, Nathalie di Clemente, Nader Hussein, Chang X. Zhang, Isabelle Coste, Marie J. Asensio, Huguette Casse, Jie L. Lu, Anne-Marie Morera, Sandra Fontanière, Skander Bakeli

Publikováno v: European Journal of Cancer
European Journal of Cancer, Elsevier, 2007, 43 (2), pp.402-414

International audience; Multiple endocrine neoplasia. type 1 (MEN1) is a hereditary syndrome caused by the inactivation of the responsible gene, MEN1. To date, the lack of MEN1-deficient cell lines derived directly from MEN1 tumours has hampered the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f749ae1bb5689196d4f831973f650b3b
https://pubmed.ncbi.nlm.nih.gov/17184987

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Analysis of p27(Kip1) expression in insulinomas developed in pancreatic beta-cell specific Men1 mutant mice

Autor: Chang Xian Zhang, Philippe Bertolino, Sandra Fontanière, Huguette Casse

Publikováno v: Familial cancer. 5(1)

Multiple Endocrine Neoplasia type 1 (MEN1) is a hereditary disease characterised by the occurrence of multiple endocrine tumours. The biological functions of the responsible gene, MEN1, and its encoded protein, menin, remain so far largely elusive. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e32ee56e31db9f076c86f478030e84
https://pubmed.ncbi.nlm.nih.gov/16528608

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