Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sandra F Gallego"'
Autor:
Josch K Pauling, Martin Hermansson, Jürgen Hartler, Klaus Christiansen, Sandra F Gallego, Bing Peng, Robert Ahrends, Christer S Ejsing
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188394 (2017)
Advances in mass spectrometry-based lipidomics have in recent years prompted efforts to standardize the annotation of the vast number of lipid molecules that can be detected in biological systems. These efforts have focused on cataloguing, naming and
Externí odkaz:
https://doaj.org/article/116b0c47a2a54f21b3dcbca12c694c4e
Autor:
Christer S. Ejsing, Sandra F Gallego, Anthony H. Futerman, Richard R. Sprenger, Ole N. Jensen, Nanna Albæk, Steffen Schmidt, Marie W. Lindholm, Charlotte Øverup, Yael Pewzner-Jung, Sergey Kovalchuk, Iris D. Zelnik
Publikováno v:
Mol Ther
Schmidt, S, Gallego, S F, Zelnik, I D, Kovalchuk, S, Albæk, N, Sprenger, R R, Øverup, C, Pewzner-Jung, Y, Futerman, A H, Lindholm, M W, Jensen, O N & Ejsing, C S 2022, ' Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death ', Molecular Therapy, vol. 30, no. 4, pp. 1661-1674 . https://doi.org/10.1016/j.ymthe.2021.08.021
Schmidt, S, Gallego, S F, Zelnik, I D, Kovalchuk, S, Albæk, N, Sprenger, R R, Øverup, C, Pewzner-Jung, Y, Futerman, A H, Lindholm, M W, Jensen, O N & Ejsing, C S 2022, ' Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death ', Molecular Therapy, vol. 30, no. 4, pp. 1661-1674 . https://doi.org/10.1016/j.ymthe.2021.08.021
Emerging clinical data show that three ceramide molecules, Cer d18:1/16:0, Cer d18:1/24:1, and Cer d18:1/24:0, are biomarkers of a fatal outcome in patients with cardiovascular disease. This finding raises basic questions about their metabolic origin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b0e637383248c3671fcfcbf8c482c6
https://doi.org/10.1016/j.ymthe.2021.08.021
https://doi.org/10.1016/j.ymthe.2021.08.021
Autor:
Adekunle T. Bademosi, Marianna Decet, Sabine Kuenen, Carles Calatayud, Jef Swerts, Sandra F. Gallego, Nils Schoovaerts, Spyridoula Karamanou, Nikolaos Louros, Ella Martin, Jean-Baptiste Sibarita, Katlijn Vints, Natalia V. Gounko, Frédéric A. Meunier, Anastassios Economou, Wim Versées, Frederic Rousseau, Joost Schymkowitz, Sandra-F. Soukup, Patrik Verstreken
Publikováno v:
Neuron. 111:1402-1422.e13
Neuronal activity causes use-dependent decline in protein function. However, it is unclear how this is coupled to local quality control mechanisms. We show in Drosophila that the endocytic protein Endophilin-A (EndoA) connects activity-induced calciu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0810cbd9c9d27c4f1798bb2adf77be17
https://doi.org/10.1016/j.neuron.2023.02.001
https://doi.org/10.1016/j.neuron.2023.02.001
Autor:
Adekunle T. Bademosi, Marianna Decet, Sabine Kuenen, Carles Calatayud, Jef Swerts, Sandra F Gallego, Nils Schoovaerts, Nikolaos Louros, Ella Martin, Spyridoula Karamanou, Jean-Baptiste Sibarita, Katlijn Vints, Natalia V. Gounko, Frédéric A. Meunier, Anastassios Economou, Wim Versées, Frederic Rousseau, Joost Schymkowitz, Sandra-F. Soukup, Patrik Verstreken
Neuronal activity and neurotransmitter release cause use-dependent decline in protein function. However, it is unclear how this is coupled to local protein turnover and quality control mechanisms. Here we show that the endocytic protein Endophilin-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cfc352cf7c293cb641e007cb4ca4881
https://doi.org/10.1101/2022.04.29.490010
https://doi.org/10.1101/2022.04.29.490010
Autor:
Sandra F. Gallego, Antonio Pisani, Christine Klein, Patrik Verstreken, Philip Seibler, Joyce Foroozandeh, Rose E. Goodchild, Ana Cascalho, Maria Meringolo, Lise Hennebel, Jef Swerts, Beatriz Dominguez Gonzalez, Stef Rous
Publikováno v:
Brain
TOR1A/TorsinA mutations cause two incurable diseases: a recessive congenital syndrome that can be lethal, and a dominantly-inherited childhood-onset dystonia (DYT-TOR1A). TorsinA has been linked to phosphatidic acid lipid metabolism in Drosophila mel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d813482960f81ccf094ae4766b4705cb
https://doi.org/10.1093/brain/awaa139
https://doi.org/10.1093/brain/awaa139
Autor:
Joyce Foroozandeh, Julie Jacquemyn, Sandra F. Gallego, Rose E. Goodchild, Patrik Verstreken, Natalia V. Gounko, Katlijn Vints, Jef Swerts
Publikováno v:
The EMBO Journal
The interphase nuclear envelope (NE) is extensively remodeled during nuclear pore complex (NPC) insertion. How this remodeling occurs and why it requires Torsin ATPases, which also regulate lipid metabolism, remains poorly understood. Here, we show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d8b445abf34e88ce015424738ccc19d
Autor:
Jef Swerts, Patrik Verstreken, Natalia V. Gounko, Joyce Foroozandeh, Julie Jacquemyn, Rose E. Goodchild, Sandra F. Gallego, Katlijn Vints
Torsin ATPases of the endoplasmic reticulum (ER) and nuclear envelope (NE) lumen inhibit Lipin-mediated phosphatidate (PA) to diacylglycerol (DAG) conversion by an unknown mechanism. This excess PA metabolism is implicated inTOR1A/TorsinA diseases, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf2a95ecd4da325ca47a9ff8afb8a05a
https://doi.org/10.1101/2020.07.05.188599
https://doi.org/10.1101/2020.07.05.188599
Autor:
Joyce Foroozandeh, Rose E. Goodchild, Sandra F. Gallego, Stef Rous, Ana Cascalho, Natalia Martínez Vizcaíno
SummaryThere has been enormous progress defining the genetic landscape of disease. However, genotypes rarely fully predict neurological phenotypes, and we rarely understand why.TOR1A+/Δgag that causes dystonia with ~30% penetrance is a classic case.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5789519b064fa92b6bc4c5b8e8f3d293
https://doi.org/10.1101/2020.03.18.997247
https://doi.org/10.1101/2020.03.18.997247
Publikováno v:
Gallego, S F, Højlund, K & Ejsing, C S 2018, ' Easy, Fast, and Reproducible Quantification of Cholesterol and Other Lipids in Human Plasma by Combined High Resolution MSX and FTMS Analysis ', Journal of the American Society for Mass Spectrometry, vol. 29, no. 1, pp. 34–41 . https://doi.org/10.1007/s13361-017-1829-2
Reliable, cost-effective, and gold-standard absolute quantification of non-esterified cholesterol in human plasma is of paramount importance in clinical lipidomics and for the monitoring of metabolic health. Here, we compared the performance of three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2580b0b1879ca34305470161bc18df4b
https://doi.org/10.1007/s13361-017-1829-2
https://doi.org/10.1007/s13361-017-1829-2
Autor:
Sandra F. Gallego, Beatriz Dominguez Gonzalez, Ana Cascalho, Antonio Pisani, Hennebel L, Christine Klein, Patrik Verstreken, Maria Meringolo, Philip Seibler, Joyce Foroozandeh, Stef Rous, Rose E. Goodchild
TOR1A/TorsinA mutations cause poorly explained neurological diseases. A dominantly inherited mutation causes isolated dystonia, while biallelic mutations cause a recessive infant-onset syndrome with cases of lethality. Here we report an unexpected co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d61d45e2a0317fdee97696135e42ec