Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Sandra E. Graham"'
Autor:
Andrzej Pastuszyn, Rita E. Serda, Andrew J. Annalora, John L. Omdahl, Sandra E. Graham, Ekaterina Bobrovnikov-Marjon, Craig B. Marcus
Publikováno v:
Archives of Biochemistry and Biophysics. 460:262-273
Cytochrome P450C24A1 (CYP24A1), a peripheral inner mitochondrial membrane hemoprotein and candidate oncogene, regulates the side-chain metabolism and biological function of vitamin D and many of its related analog drugs. Rational mutational analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a67ed7891abf42c8b5b836b9055c0c
https://doi.org/10.1016/j.abb.2006.11.018
https://doi.org/10.1016/j.abb.2006.11.018
Autor:
Justin R. Scott, Andrew G. Pearson, Katey Witham, Carwyn Davies, Elizabeth M. J. Gillam, Sandra E. Graham, James J. DeVoss
Publikováno v:
Drug Metabolism and Disposition. 32:431-436
CYP2C9 is distinguished by a preference for substrates bearing a negative charge at physiological pH. Previous studies have suggested that CYP2C9 residues R97 and K72 may play roles in determining preference for anionic substrates by interaction at t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5379f0d97090cfc7a442370cae83030e
https://doi.org/10.1124/dmd.32.4.431
https://doi.org/10.1124/dmd.32.4.431
Publikováno v:
Molecular Endocrinology. 16:1456-1468
The porcine gonadal form of aromatase cytochrome P450 (P450arom) exhibits higher sensitivity to inhibition by the imidazole, etomidate, than the placental isozyme. The residue(s) responsible for this functional difference was mapped using chimeragene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f0e537e24de4845fb97f6f8a699ded
https://doi.org/10.1210/mend.16.7.0876
https://doi.org/10.1210/mend.16.7.0876
Autor:
Ronald W. Estabrook, Natalya V. Strushkevich, Sandra E. Graham, Julian A. Peterson, Tamara N. Azeva, Andrei A. Gilep, Galina I. Lepesheva, Sergey A. Usanov
Publikováno v:
Biochemistry. 41:8310-8320
The present study was undertaken to evaluate the role of positively charged amino acid residues proposed to reside on the proximal surface of bovine cytochrome P450 cholesterol side chain cleavage (P450scc, CYP11A1) and to determine which residues ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091cd4fb9e469854c072b47a9ac9ff40
https://doi.org/10.1021/bi0255928
https://doi.org/10.1021/bi0255928
Autor:
Sandra E. Graham
Publikováno v:
Current Directions in Psychological Science. 7:165-170
Many institutions of higher edu cation today are working to pro vide a psychology curriculum that both enables students to engage in the critical-thinking processes of psychology and equips graduates to practice sound psychological principles within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e802221fd6ead25cf080c41a7e78ed
https://doi.org/10.1111/j.1467-8721.1998.tb00222.x
https://doi.org/10.1111/j.1467-8721.1998.tb00222.x
Publikováno v:
Metabolism. 47:1383-1390
Studies were performed to test the hypothesis that the stress response is exaggerated in obesity and to identify which component of the response is modified. Chronically cannulated lean (+/+) and obese (cp/cp) JCR:LA rats were subjected to mild restr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482fda677cc82b4ff02a7568370013a6
https://doi.org/10.1016/s0026-0495(98)90310-9
https://doi.org/10.1016/s0026-0495(98)90310-9
Publikováno v:
Journal of Cardiovascular Pharmacology. 31:971-977
The JCR:LA-cp rat is a unique strain that, if homozygous for the autosomal recessive cp gene, is obese and exhibits the metabolic syndrome of insulin resistance, hyperinsulinemia, and hypertriglyceridemia. Obese male rats spontaneously develop advanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceda2583bccaeec08b50d80d1cbb19da
https://doi.org/10.1097/00005344-199806000-00024
https://doi.org/10.1097/00005344-199806000-00024
Publikováno v:
European Journal of Pharmacology. 350:203-210
Probucol is an antihyperlipidemic agent with antioxidant effects and antiatherosclerotic properties in hypercholesterolemic conditions. The JCR:LA-corpulent strain of rats exhibits all aspects of the human 'metabolic syndrome' characterized by obesit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5fc54cf62ba5e1474c20c0b63c54ef
https://doi.org/10.1016/s0014-2999(98)00244-1
https://doi.org/10.1016/s0014-2999(98)00244-1
Autor:
Sandra E. Graham, L. M. Wenzel, Mary Richardson, G. Shillabeer, James C. Russell, P J Dolphin, D. C. W. Lau, J. Bar-Tana
Publikováno v:
Diabetes. 47:770-778
The JCR:LA-cp rat develops an extreme obese/insulin-resistant syndrome such that by 12 weeks of age, there is no longer any insulin-mediated glucose turnover. At 4 weeks of age, obese and lean rats have essentially identical basal and insulin-mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3600a861867b665aa11e80ce30fe6e82
https://doi.org/10.2337/diabetes.47.5.770
https://doi.org/10.2337/diabetes.47.5.770
Publikováno v:
Diabetologia. 41:380-389
Obese male rats of the JCR:LA-cp strain are insulin resistant, normoglycaemic, hypertriglyceridaemic, and atherosclerosis-prone. Such rats were treated from 6 to 39 weeks of age with 5 mg · kg–1· day–1 of d-fenfluramine. The treatment normalise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870769088fb07e71dd09f51da25e02ae
https://doi.org/10.1007/s001250050920
https://doi.org/10.1007/s001250050920