Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Sandra E Wiley"'
Autor:
Adam J Pollak, Canzhao Liu, Aparna Gudlur, Joshua E Mayfield, Nancy D Dalton, Yusu Gu, Ju Chen, Joan Heller Brown, Patrick G Hogan, Sandra E Wiley, Kirk L Peterson, Jack E Dixon
Publikováno v:
eLife, Vol 7 (2018)
Ca2+ signaling is important for many cellular and physiological processes, including cardiac function. Although sarcoplasmic reticulum (SR) proteins involved in Ca2+ signaling have been shown to be phosphorylated, the biochemical and physiological ro
Externí odkaz:
https://doaj.org/article/ecc097f1b4894d6997ab24d9a2cc0ed7
Autor:
Jerry R Colca, William G McDonald, Gregory S Cavey, Serena L Cole, Danielle D Holewa, Angela S Brightwell-Conrad, Cindy L Wolfe, Jean S Wheeler, Kristin R Coulter, Peter M Kilkuskie, Elena Gracheva, Yulia Korshunova, Michelle Trusgnich, Robert Karr, Sandra E Wiley, Ajit S Divakaruni, Anne N Murphy, Patrick A Vigueira, Brian N Finck, Rolf F Kletzien
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e61551 (2013)
Thiazolidinedione (TZD) insulin sensitizers have the potential to effectively treat a number of human diseases, however the currently available agents have dose-limiting side effects that are mediated via activation of the transcription factor PPARγ
Externí odkaz:
https://doaj.org/article/810bfe5fc88043a1a3d87fdcdaabf016
Autor:
Vasudha Tandon, Rita Moreno, Kira Allmeroth, Jean Quinn, Sandra E. Wiley, Lynden G. Nicely, Martin S. Denzel, Joanne Edwards, Laureano de la Vega, Sourav Banerjee
Publikováno v:
Biosci Rep.
Preserving proteostasis is a major survival mechanism for cancer. Dual specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) is a key oncogenic kinase that directly activates the transcription factor heat-shock factor 1 (HSF1) and the 26S p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c2db095d9e03c1e0cfaadaa653e515
https://hdl.handle.net/21.11116/0000-000C-969A-D21.11116/0000-000C-969C-B
https://hdl.handle.net/21.11116/0000-000C-969A-D21.11116/0000-000C-969C-B
Autor:
Katie H. Hurrish, Yongwei Su, Shraddha Patel, Sandra E. Wiley, Zhanjun Hou, Jenna Carter, Hasini Kalpage, Maik Hüttemann, Connie Weng, Holly Edwards, Lisa Polin, Jing Li, Jay Yang, Larry H. Matherly, Sergej Naumovich Konoplev, Jeffrey W. Taub, Marina Konopleva, Yubin Ge, Natalia Baran
Publikováno v:
Cancer Research. 82:3785-3785
Acute myeloid Leukemia (AML) is an aggressive hematologic malignancy with poor prognosis. Despite chromosomal and genetic heterogeneity, AML are uniformly characterized by increased reliance on oxidative phosphorylation (OXPHOS). This key metabolic h
Autor:
Shixian Lin, Jack E. Dixon, Natalie Chen, Weidi Xiao, Yawen Zheng, Ping Xu, Lu Chen, Xiaoyan Liu, Tao Zuo, Lan Huang, Sandra E. Wiley, Yingying Zheng, Yanan Zhang, Xing Guo, Xiaorong Wang, Anne N. Murphy
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 1
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 1
The fundamental importance of the 26S proteasome in health and disease suggests that its function must be finely controlled, and yet our knowledge about proteasome regulation remains limited. Posttranslational modifications, especially phosphorylatio
Autor:
Jenna J Lee, Haydee L. Gutierrez, Sourav Banerjee, Junyu Xiao, Liang Ruqi, Sandra E. Wiley, Vasudha Tandon, Tiantian Wei, Jue Wang, Kimberly L. Cooper, Lukas Chavez, Edwin F. Juarez, Xiaoguang Lei, Caitlin Costello, Jack E. Dixon, Owen Chapman, Laureano de la Vega, Jill P. Mesirov, Robert L. Sah, Joshua E. Mayfield
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 49
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Multiple myeloma (MM) and triple-negative breast cancer (TNBC) are dependent on 26S proteasome for malignancy. We have previously shown that the proteasome-regulating kinase DYRK2 is a viable target for both MM and TNBC. Here we identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7db7d51ffd9e6896fe3714cfa965dda
https://escholarship.org/uc/item/10h2v4tz
https://escholarship.org/uc/item/10h2v4tz
Autor:
Jeffrey W. Taub, Jing Li, Katie Hege Hurrish, Jay Yang, Jenna L. Carter, Zhanjun Hou, Yongwei Su, Yubin Ge, Lisa Polin, Hasini A. Kalpage, Holly Edwards, Maik Hüttemann, Larry H. Matherly, Sandra E. Wiley
Publikováno v:
Blood. 138:2238-2238
The 5-year survival rate for adult patients with acute myeloid leukemia (AML) treated with cytarabine-based chemotherapy remains less than 30%, due to drug resistance and disease relapse. Recently, a selective inhibitor of anti-apoptotic Bcl-2, venet
Publikováno v:
Cancer Research. 81:1962-1962
Mutations in KRAS at G12, G13, and Q61 are oncogenic drivers in many cancers, including lung, colorectal, pancreatic, multiple myeloma, and uterine carcinomas. KRAS mutations are frequently accompanied by stabilization of the MYC oncoprotein through
Autor:
Adam J. Pollak, Sandra E. Wiley, Philip Bidwell, Evangelia G. Kranias, Despina Sanoudou, Kobra Haghighi, Guan-Sheng Liu, Demetrios A. Arvanitis, Vivek P. Singh, Jack E. Dixon, David Gonzalez, Swati Kunduri
Publikováno v:
Proceedings of the National Academy of Sciences. 114:9098-9103
Precise Ca cycling through the sarcoplasmic reticulum (SR), a Ca storage organelle, is critical for proper cardiac muscle function. This cycling initially involves SR release of Ca via the ryanodine receptor, which is regulated by its interacting pro
Autor:
Aparna Gudlur, Kirk L. Peterson, Joan Heller Brown, Adam J. Pollak, Patrick G. Hogan, Yusu Gu, Nancy D. Dalton, Joshua E. Mayfield, Canzhao Liu, Jack E. Dixon, Sandra E. Wiley, Ju Chen
Publikováno v:
Pollak, Adam J; Liu, Canzhao; Gudlur, Aparna; Mayfield, Joshua E; Dalton, Nancy D; Gu, Yusu; et al.(2018). A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure.. eLife, 7. doi: 10.7554/eLife.41378. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/6399b99w
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Ca2+ signaling is important for many cellular and physiological processes, including cardiac function. Although sarcoplasmic reticulum (SR) proteins involved in Ca2+ signaling have been shown to be phosphorylated, the biochemical and physiological ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021b212fc3ce0abe294c1789475c2881
https://escholarship.org/uc/item/6399b99w
https://escholarship.org/uc/item/6399b99w