Grass pollen allergoids conjugated with mannan for subcutaneous and sublingual immunotherapy: a dose-finding study

Autor: Pedro Ojeda, María Concepción Barjau, Javier Subiza, Antonio Moreno, Isabel Ojeda, Emilio Solano, Alicia Alonso, Raquel Caballero, Sandra Del Pozo, Marta Gómez-Perosanz, José Luis Sánchez-Trincado, Cristina Benito-Villalvilla, Alba Angelina, Irene Soria, Pedro A. Reche, Oscar Palomares, José Luis Subiza, Miguel Casanovas

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundPolymerized allergoids conjugated with mannan represent a novel approach of allergen immunotherapy targeting dendritic cells. In this study, we aimed to determine the optimal dose of mannan-allergoid conjugates derived from grass pollen (Ph

Externí odkaz: https://doaj.org/article/68dbca2d079b4619a7822b69b8d02335

First-in-human phase 2 trial with mite allergoids coupled to mannan in subcutaneous and sublingual immunotherapy

Autor: Antonio Nieto, Ángel Mazón, María Nieto, Ethel Ibáñez, Dah‐Tay Jang, Susana Calaforra, Pilar Alba, Carmen Pérez‐Francés, Ruth Llusar, Javier Montoro, Antonio de Mateo, Remedios Alamar, David El‐Qutob, Javier Fernández, Luis Moral, Teresa Toral, Mónica Antón, Carmen Andreu, Ángel Ferrer, Isabel‐María Flores, Neus Cerdá, Sandra del Pozo, Raquel Caballero, José Luis Subiza, Miguel Casanovas

Publikováno v: ALLERGY
r-FISABIO. Repositorio Institucional de Producción Científica
instname
Allergy
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante

BACKGROUND: Polymerized allergens conjugated to non-oxidized mannan (PM-allergoids) are novel vaccines targeting dendritic cells (DCs). Previous experimental data indicate that PM-allergoids are readily taken up by DCs and induce Treg cells. This fir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec043affedbe32c891e276da6d125a6
https://pubmed.ncbi.nlm.nih.gov/35570712

Synthesis of β-Hydroxy α-Amino Acids Through Brønsted Base-Catalyzed

Autor: Silvia, Vera, Ana, Vázquez, Ricardo, Rodriguez, Sandra Del, Pozo, Iñaki, Urruzuno, Abel de, Cózar, Antonia, Mielgo, Claudio, Palomo

Publikováno v: The Journal of organic chemistry. 86(11)

Here we report the highly enantio- and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::710313ef86020ec68da5b21c0f960c98
https://pubmed.ncbi.nlm.nih.gov/33998227

Highly Enantioselective Construction of Tricyclic Derivatives by the Desymmetrization of Cyclohexadienones

Autor: Silvia Cabrera, José Alemán, Sandra del Pozo, Rubén Mas-Ballesté, Carlos Jarava-Barrera, Cecilia Martín-Santos, Sergio Díaz-Tendero, Alejandro Parra

Publikováno v: Angewandte Chemie. 126:8323-8328

The asymmetric synthesis of tricyclic compounds by the desymmetrization of cyclohexadienones is presented. The reaction tolerated a large variety of substituents at different positions of the cyclohexadienone, and heterocyclic rings of different size

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c830a537e2ab816f17a44911162c0892
https://doi.org/10.1002/ange.201402853