Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sandra D. Scherer"'
Autor:
Sandra D. Scherer, Ling Zhao, Andrew J. Butterfield, Chieh-Hsiang Yang, Emilio Cortes-Sanchez, Katrin P. Guillen, Bryan E. Welm, Alana L. Welm
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102402- (2023)
Summary: Patient-derived xenografts (PDXs) have clinical value but are time-, cost-, and labor-intensive and thus ill-suited for large-scale experiments. Here, we present a protocol to convert PDX tumors into PDxOs for long-term cultures amenable to
Externí odkaz:
https://doaj.org/article/caabe65db8564dada1e80756fb6070c9
Autor:
Edward R. Polanco, Tarek E. Moustafa, Andrew Butterfield, Sandra D. Scherer, Emilio Cortes-Sanchez, Tyler Bodily, Benjamin T. Spike, Bryan E. Welm, Philip S. Bernard, Thomas A. Zangle
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
The authors developed a real-time and label-free approach based on quantitative phase imaging to determine drug sensitivity with significant advantages over endpoint viability or metabolic assays, and which reveals single cell response heterogeneity.
Externí odkaz:
https://doaj.org/article/bdafcd4216674d5e8612300cafe2762b
Autor:
Sandra D. Scherer, Alessandra I. Riggio, Fadi Haroun, Yoko S. DeRose, H. Atakan Ekiz, Maihi Fujita, Jennifer Toner, Ling Zhao, Zheqi Li, Steffi Oesterreich, Ahmed A. Samatar, Alana L. Welm
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-18 (2021)
Abstract Background Metastatic breast cancer (MBC) is incurable, with a 5-year survival rate of 28%. In the USA, more than 42,000 patients die from MBC every year. The most common type of breast cancer is estrogen receptor-positive (ER+), and more pa
Externí odkaz:
https://doaj.org/article/9f5a018b7d5f4111b5c00b06970d1c1d
Autor:
Sabarinath V. Radhakrishnan, Tim Luetkens, Sandra D. Scherer, Patricia Davis, Erica R. Vander Mause, Michael L. Olson, Sara Yousef, Jens Panse, Yasmina Abdiche, K. David Li, Rodney R. Miles, William Matsui, Alana L. Welm, Djordje Atanackovic
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
CD229 is expressed on the surface of multiple myeloma cells, as well as B and T lymphocytes. Here, the authors engineer CD229-specific CAR T cells and, using patient samples and mouse models, show that treatment with these cells reduces tumour burden
Externí odkaz:
https://doaj.org/article/4e432057e84c4bb2853dee941535a21e
Autor:
Dror Alishekevitz, Svetlana Gingis-Velitski, Orit Kaidar-Person, Lilach Gutter-Kapon, Sandra D. Scherer, Ziv Raviv, Emmanuelle Merquiol, Yael Ben-Nun, Valeria Miller, Chen Rachman-Tzemah, Michael Timaner, Yelena Mumblat, Neta Ilan, David Loven, Dov Hershkovitz, Ronit Satchi-Fainaro, Galia Blum, Jonathan P. Sleeman, Israel Vlodavsky, Yuval Shaked
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1344-1356 (2016)
Summary: While chemotherapy strongly restricts or reverses tumor growth, the response of host tissue to therapy can counteract its anti-tumor activity by promoting tumor re-growth and/or metastases, thus limiting therapeutic efficacy. Here, we show t
Externí odkaz:
https://doaj.org/article/33aac968c8234da399706c8ab64ff755
Autor:
Jason Gertz, Barbara J. Graves, Margit M. Janát-Amsbury, Bryan E. Welm, Chieh-Hsiang Yang, Sandra D. Scherer, Katrin P. Guillen, Kathleen A. Clark, Kristofer C. Berrett, Jeffery M. Vahrenkamp, Adriana C. Rodriguez
SF1: ETV4 expression levels in endometrial cancer. SF2: Expression levels of ETV4 in candidate knockout clones. SF3: Short-term knockdown of ETV4 reduces ER genomic binding. SF4: Validation of rescue and overexpression of ETV4. SF5: Estrogen induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20fca2f95362a815a5d7fe76da38aef1
https://doi.org/10.1158/0008-5472.22424760.v1
https://doi.org/10.1158/0008-5472.22424760.v1
Autor:
Jason Gertz, Barbara J. Graves, Margit M. Janát-Amsbury, Bryan E. Welm, Chieh-Hsiang Yang, Sandra D. Scherer, Katrin P. Guillen, Kathleen A. Clark, Kristofer C. Berrett, Jeffery M. Vahrenkamp, Adriana C. Rodriguez
Estrogen signaling through estrogen receptor alpha (ER) plays a major role in endometrial cancer risk and progression, however, the molecular mechanisms underlying ER's regulatory role in endometrial cancer are poorly understood. In breast cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c44e4c068cc19c3774e56c196660b729
https://doi.org/10.1158/0008-5472.c.6511863.v1
https://doi.org/10.1158/0008-5472.c.6511863.v1
Autor:
Joseph R Casalini, Chelsea U Kidwell, Soorya Pradeep, Sandra D Scherer, Daniel Greiner, Defne Bayik, Dionysios C Watson, Gregory S Olson, Justin D Lathia, Jarrod S Johnson, Jared Rutter, Alana L Welm, Thomas A Zangle, Minna Roh-Johnson
Publikováno v:
eLife. 12
Recent studies reveal that lateral mitochondrial transfer, the movement of mitochondria from one cell to another, can affect cellular and tissue homeostasis. Most of what we know about mitochondrial transfer stems from bulk cell studies and have led
Autor:
Katrin P. Guillen, Maihi Fujita, Andrew J. Butterfield, Sandra D. Scherer, Matthew H. Bailey, Zhengtao Chu, Yoko S. DeRose, Ling Zhao, Emilio Cortes-Sanchez, Chieh-Hsiang Yang, Jennifer Toner, Guoying Wang, Yi Qiao, Xiaomeng Huang, Jeffery A. Greenland, Jeffery M. Vahrenkamp, David H. Lum, Rachel E. Factor, Edward W. Nelson, Cindy B. Matsen, Jane M. Poretta, Regina Rosenthal, Anna C. Beck, Saundra S. Buys, Christos Vaklavas, John H. Ward, Randy L. Jensen, Kevin B. Jones, Zheqi Li, Steffi Oesterreich, Lacey E. Dobrolecki, Satya S. Pathi, Xing Yi Woo, Kristofer C. Berrett, Mark E. Wadsworth, Jeffrey H. Chuang, Michael T. Lewis, Gabor T. Marth, Jason Gertz, Katherine E. Varley, Bryan E. Welm, Alana L. Welm
Publikováno v:
Nature Cancer. 3:232-250
Models that recapitulate the complexity of human tumors are urgently needed to develop more effective cancer therapies. We report a bank of human patient-derived xenografts (PDXs) and matched organoid cultures from tumors that represent the greatest
Autor:
Joseph R Casalini, Chelsea U Kidwell, Soorya Pradeep, Sandra D Scherer, Daniel Greiner, Defne Bayik, Dionysios C Watson, Gregory S Olson, Justin D Lathia, Jarrod S Johnson, Jared Rutter, Alana L Welm, Thomas A Zangle, Minna Roh-Johnson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37199cdbe46035901be1e3e0fa52c85e
https://doi.org/10.7554/elife.85494.sa2
https://doi.org/10.7554/elife.85494.sa2