Výsledky vyhledávání - "Sandra D. Nkandeu"

A Novel 2-Methoxyestradiol Analogue Is Responsible for Vesicle Disruption and Lysosome Aggregation in Breast Cancer Cells

Autor: Sandra D. Nkandeu, Anna Margaretha Joubert, Marianne J. Cronjé, Iman van den Bout, Dirk van Papendorp

Publikováno v: Pharmacology. 102(1-2)

Background: 2-Methoxyestradiol (2ME2) is an endogenous metabolite of 17-β-estradiol with anti-proliferative and anti-angiogenic properties. Due to 2ME2’s rapid metabolism and low oral bioavailability in in vivo settings, 2ME2 analogues have been d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a1fb77c6125f7acc8ec575b76b2225
https://pubmed.ncbi.nlm.nih.gov/29672318

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Novel estradiol analogue induces apoptosis and autophagy in esophageal carcinoma cells

Autor: T.V. Mqoco, Andre Stander, Robert McKenna, Sandra D. Nkandeu, Elize Wolmarans, Annie M. Joubert, Katherine H. Sippel

Publikováno v: Cellular & Molecular Biology Letters

Cancer is the second leading cause of death in South Africa. The critical role that microtubules play in cell division makes them an ideal target for the development of chemotherapeutic drugs that prevent the hyperproliferation of cancer cells. The n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34222cc734ecc12aee58ce082e4c7f7
http://europepmc.org/articles/PMC6275608

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Effects of estradiol analogues on blood: A pilot study

Autor: Barend Andre Stander, T. Piorkowski, Sandra D. Nkandeu, Elize Wolmarans, Annie M. Joubert, Anne Elisabeth Theron, Lisa Repsold, T.V. Mqoco

Publikováno v: Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie. 33

Effects of estradiol analogues on blood : a pilot study This study demonstrated that both ESE-15-ol en ESE-16 have no effect on blood cells. Future ex vivo and in vivo studies into the mechanism of these potentially anticancer drugs are warranted.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f1bf6f29b7bcabc52adc64e3010e2a9
https://doi.org/10.4102/satnt.v33i1.1251

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Ultrastructural changes of erythrocytes in whole blood after exposure to prospective in silico-designed anticancer agents: a qualitative case study

Autor: Tomek Piorkowski, Sandra D. Nkandeu, J. J. Theron, Peet J. Du Toit, T.V. Mqoco, Lisa Repsold, Elize Wolmarans, Annie M. Joubert, Dirk van Papendorp

Publikováno v: Biological Research v.47 2014
SciELO Chile
CONICYT Chile
instacron:CONICYT
Biological Research
Biological Research, Volume: 47, Pages: 1-7, Published: 2014
Biological Research, Vol 47, Iss 0, Pp 1-7 (2014)

BACKGROUND: Novel, in silico-designed anticancer compounds were synthesized in our laboratory namely, 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol) and 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16). These compounds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ba7643b6bcec26f2ae7d21f02cbfd7
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100039

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In vitro veranderinge in mitochondriale membraan potensiaal, aggresoom formasie en kaspase aktiwiteit deur 'n nuwe 17-β-estradiol analoog in bors adenokarsinoomselle

Autor: Barend Andre Stander, Sandra D. Nkandeu, Michelle H. Visagie, Sumari Marais, Annie M. Joubert, T.V. Mqoco

Publikováno v: South African Journal of Science and Technology, Vol 31, Iss 1 (2012)

Die natuurlike metaboliet van estradiol, naamlik 2-metoksieëstradiol (2ME2) oefen antiproliferatiewe en anti-tumor effekte in vitro en in vivo uit met minimale of geen toksisiteit nie.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cffd5f10167cb7a2ff983f3d042e76a
https://doi.org/10.4102/satnt.v31i1.297

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