Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sandra D. Kirley"'
Autor:
Bo R. Rueda, Sandra D. Kirley, Maria Pino, Lawrence R. Zukerberg, Daniel C. Chung, Thomas Arnason, Ömer H. Yilmaz
Publikováno v:
Cancer Biology & Therapy. 14:672-678
The transformation of colonic mucosal epithelium to adenocarcinoma requires progressive oncogene activation and tumor suppressor gene inactivation. Loss of chromosome 18q is common in colon cancer but not in precancerous adenomas. A few candidate tum
Autor:
Hai Ou Duan, Hua Xiao, Yifen Zhang, Hui H. Zhang, W. Scott McDougal, Sharron X. Lin, Chin-Lee Wu, Sandra D. Kirley
Publikováno v:
International Journal of Cancer. 123:810-816
Tat-interacting protein 30 (TIP30), a transcriptional repressor for ERalpha-mediated transcription, possesses several characteristics of a tumor suppressor in certain human and mouse cells. It is reported that deletion of TIP30 gene preferentially in
Publikováno v:
Cancer Biology & Therapy. 4:654-658
Cables (Cables1), a recently described growth suppressor protein that maps to human chromosome 18q11-12, is lost in many primary colon, lung, and gynecological malignancies. Cultured cell lines that overexpress Cables show a reduction in cell prolife
Autor:
Linda R. Duska, Sandra D. Kirley, Hongwei Luo, Lawrence R. Zukerberg, Ramey D. Littell, Bo R. Rueda, Robert L. DeBernardo, Maureen P. Lynch, Esther Oliva
Publikováno v:
Cancer Biology & Therapy. 4:110-114
Loss of Cables expression is associated with a high incidence of endometrial hyperplasia and endometrial adenocarcinoma in humans. The Cables mutant mouse develops endometrial hyperplasia and following exposure to chronic estrogen develops early endo
Autor:
Linda R. Duska, Robert L. DeBernardo, Sandra D. Kirley, Lawrence R. Zukerberg, Maureen P. Lynch, Massimo D'Apuzzo, Ramey D. Littell, Bo R. Rueda, Landin Boring
Publikováno v:
Cancer Research. 64:202-208
Endometrial cancer is the most common gynecological cancer in Western industrialized countries. Cables, a cyclin-dependent kinase binding protein, plays a role in proliferation and/or differentiation. Cables mutant mice are viable, but develop endome
Publikováno v:
Journal of Urology. 166:678-683
Stromal-epithelial interactions of growth factors and the androgen receptor may have implications for the pathophysiology of benign and neoplastic transformation of the human adult prostate. We investigated a possible interaction of keratinocyte grow
Autor:
Chi-Wei Lin, Bernhard Planz, Qifa Wang, Sandra D. Kirley, Shahin Tabatabaei, H. Thomas Aretz, W. Scott McDougal
Publikováno v:
The Prostate. 41:233-242
BACKGROUND Growth and development of the prostate are androgen-dependent. Keratinocyte growth factor (KGF), widely expressed by mesenchymal cells, is thought to act like an andromedin between stroma and epithelium of the prostate. Since KGF has recen
Autor:
Shahin Tabatabaei, Sandra D. Kirley, Qifa Wang, H. Thomas Aretz, Bernhard Planz, W. Scott McDougal
Publikováno v:
The Journal of Urology. :1329-1336
Purpose: There is a lack of suitable in vitro models for the human prostate. To study stromal-epithelial interactions, we established stromal cells in cultures from benign and malignant prostate tissue that resemble more closely the in vivo condition
Publikováno v:
The Journal of Urology. :1850-1855
Growth and development of the prostate are androgen dependent and mainly influenced by stromal-epithelial interaction. It is believed that indirect androgenic activation of paracrine factors like keratinocyte growth factor (KGF) in the prostatic stro
Autor:
Chi‐Wei ‐W Lin, Janine R. Shulok, James W. Foley, Margaret E. Sherwood, Cindy M. Bachelder, Sandra D. Kirley, Louis Cincotta, Thomas J. Flotte
Publikováno v:
Photochemistry and Photobiology. 58:81-91
Previous studies have established that a number of Nile blue derivatives are potent photosensitizers and that they are localized primarily in the lysosomes. The present study examines whether the lysosome is a main target of the photocytotoxic action