Tumor-Derived Extracellular Vesicles Activate Normal Human Fibroblasts to a Cancer-Associated Fibroblast-Like Phenotype, Sustaining a Pro-Tumorigenic Microenvironment

Autor: Ilaria Giusti, Marianna Di Francesco, Giuseppina Poppa, Letizia Esposito, Sandra D’Ascenzo, Vincenza Dolo

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Fibroblasts in the tumor microenvironment have been proven to actively participate in tumor progression; they can be “educated” by cancer cells acquiring an activated state and, as such, are identified as cancer-associated fibroblasts (CAFs); CAF

Externí odkaz: https://doaj.org/article/d8262422e2ef43ea87942e49c89bd527

Cathepsin B Mediates the pH-Dependent Proinvasive Activity of Tumor-Shed Microvesicles

Autor: Ilaria Giusti, Sandra D’Ascenzo, Danilo Millimaggi, Giulia Taraboletti, Gaspare Carta, Nicola Franceschini, Antonio Pavan, Vincenza Dolo

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 5, Pp 481-488 (2008)

Vesicles shed by cancer cells are known to mediate several tumor-host interactions. Tumor microenvironment may, in turn, influence the release and the activity of tumor-shed microvesicles. In this study, we investigated the molecular mediators of the

Externí odkaz: https://doaj.org/article/d99c384a1b364ccaad3b69c74e5e590a

Cancer Three-Dimensional Spheroids Mimic In Vivo Tumor Features, Displaying “Inner” Extracellular Vesicles and Vasculogenic Mimicry

Autor: Ilaria Giusti, Giuseppina Poppa, Sandra D’Ascenzo, Letizia Esposito, Anna Rita Vitale, Giuseppe Calvisi, Vincenza Dolo

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11782

The role of extracellular vesicles (EVs) as mediators of cell-to-cell communication in cancer progression is widely recognized. In vitro studies are routinely performed on 2D culture models, but recent studies suggest that 3D cultures could represent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15835b8485f34595ef967cbdbfbd39e3

Breast Cancer Derived Extracellular Vesicles in Bone Metastasis Induction and Their Clinical Implications as Biomarkers

Autor: Vincenza Dolo, Laura Pizzorno, Sandra D'Ascenzo, Ilaria Giusti, Simona Taverna

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 3573, p 3573 (2020)
International journal of molecular sciences
21 (2020). doi:10.3390/ijms21103573
info:cnr-pdr/source/autori:Simona Taverna; Ilaria Giusti; Sandra D'ascenzo; Laura Pizzorno; Vincenza Dolo./titolo:Breast cancer derived extracellular vesicles in bone metastasis induction and their clinical implications as biomarkers/doi:10.3390%2Fijms21103573/rivista:International journal of molecular sciences (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:21

Cancer incidence and mortality are rapidly growing worldwide. The main risk factors for cancer can be associated with aging as well as the growth of the population and socioeconomic condition. Breast cancer, a crucial public health problem, is the se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8702510cc8a5b9cfb331ec1c69c33ad2
https://doi.org/10.3390/ijms21103573

Ovarian cancer-derived extracellular vesicles affect normal human fibroblast behavior

Autor: Gaspare Carta, Marianna Di Francesco, Maria Grazia Palmerini, Guido Macchiarelli, Ilaria Giusti, Sandra D'Ascenzo, Vincenza Dolo

It has become clear that non-tumor cells in the microenvironment, especially fibroblasts, actively participate in tumor progression. Fibroblasts conditioned by tumor cells become "activated" and, as such, are identified as CAFs (cancer-associated fib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4137b0f0c1d29a9c867369bc98c10ea
http://hdl.handle.net/11697/124103