Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sandra Craig"'
Autor:
Merissa Baxter, Elmar Nurmemmedov, Diego Altomare, Jessy M. Stafford, Danda Chapagai, Campbell McInnes, Sandra Craig, Michael D. Wyatt
Publikováno v:
Eur J Med Chem
Polo-like kinase 1 (PLK1) is a serine/threonine-protein kinase involved in cell cycle regulation and mitotic progression. Studies have shown that PLK1 is upregulated in many tumors and high levels are adversely related to a poor prognosis. Knocking d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969aa721b201d9bdb16662138b80e111
https://europepmc.org/articles/PMC9137042/
https://europepmc.org/articles/PMC9137042/
Autor:
Danda Chapagai, Merissa Baxter, Sandra Craig, Guru Ramamoorthy, Jessy Stafford, Sikirzhytski Vitali, Elmar Nurmemmedov, Campbell McInnes, Michael D. Wyatt
Publikováno v:
Cancer Research. 82:2572-2572
Polo Like Kinase 1 (PLK1) is only expressed in dividing cells and plays a critical role in several stages of mitosis. PLK1 is overexpressed in many tumor types. PLK1 inhibition selectively kills cancer cells because they are dependent on the mitotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::819a92c8aff3c9b63b0ee0197c56f064
https://doi.org/10.1158/1538-7445.am2022-2572
https://doi.org/10.1158/1538-7445.am2022-2572
Autor:
Michael D. Wyatt, Sandra Craig, Merissa Baxter, Jessy Varghese, Danda Chapagai, Campbell McInnes, Cecilia Hurtado, Elmar Nurmemmedov
Publikováno v:
ChemMedChem
The polo-box domain (PBD) of PLK1 determines mitotic substrate recognition and subcellular localization. Compounds that target PLK1 selectively are required due to the tumor-suppressor roles of PLK3. A structure-activity analysis of the PBD phosphope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645740c0fb010eb5bbde88b4927e93d9
https://europepmc.org/articles/PMC7703809/
https://europepmc.org/articles/PMC7703809/
Autor:
Michael D. Wyatt, Sandra Craig, Elmar Nurmemmedov, McInnes Campbell, Danda Chapagai, Merissa Baxter, Guru Ramamoorthy
Publikováno v:
Cancer Research. 81:1241-1241
Polo Like Kinase 1 (PLK1) is only expressed in dividing cells and plays a critical role in several stages of mitosis. PLK1 is highly expressed in tumors of various origins while its expression is largely absent in normal tissues. PLK1 inhibition sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14e5be833e71e108181b7a18994d63b2
https://doi.org/10.1158/1538-7445.am2021-1241
https://doi.org/10.1158/1538-7445.am2021-1241
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3754-3760
Inhibition of Cyclin Dependent Kinase 2 (CDK2) in complex with cyclin A in G1/S phase of the cell cycle has been shown to promote selective apoptosis of cancer cells through the E2F1 pathway. An alternative approach to catalytic inhibition is to targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb974549b8fefa054a1a2c0cd838621
https://doi.org/10.1016/j.bmcl.2016.05.067
https://doi.org/10.1016/j.bmcl.2016.05.067
Autor:
Shu Liu, Tracy L. Perkins, George Kontopidis, Padmavathy Nandha Premnath, Asterios I. Grigoroudis, Campbell McInnes, Erin L. Anderson, Sandra Craig, Douglas L. Pittman, Michael D. Wyatt
Publikováno v:
Journal of Medicinal Chemistry
The cyclin groove is an important recognition site for substrates of the cell cycle cyclin dependent kinases and provides an opportunity for highly selective inhibition of kinase activity through a non-ATP competitive mechanism. The key peptide resid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978af7660c67276d5d3f42b0bca2b722
https://doi.org/10.1021/jm5015023
https://doi.org/10.1021/jm5015023
Autor:
McKenzie, Sandra Craig
Publikováno v:
Journal of Legal Education, 1987 Sep 01. 37(3), 367-368.
Externí odkaz:
https://www.jstor.org/stable/42892960
Publikováno v:
Journal of Medicinal Chemistry. 55:2437-2451
This report describes the design and application of several distinct gold-containing indoles as anticancer agents. When used individually, all gold-bearing compounds display cytostatic effects against leukemia and adherent cancer cell lines. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d03ca143a9bdfc89d918eba19d14b5a
https://doi.org/10.1021/jm2005942
https://doi.org/10.1021/jm2005942
Autor:
Anthony J. Berdis, Jennifer Fishovitz, Kristin S. Ko, Hilary Frase, Min Li, Sandra Craig, Carolyn K. Suzuki, Irene Lee, Jason E. Hudak
Publikováno v:
ACS Chemical Biology. 6:781-788
Lon and ClpXP are the only soluble ATP-dependent proteases within the mammalian mitochondria matrix, which function in protein quality control by selectively degrading misfolded, misassembled, or damaged proteins. Chemical tools to study these protea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3833c9bfb3c1a5f92204097e2e7e6a8a
https://doi.org/10.1021/cb100408w
https://doi.org/10.1021/cb100408w
Autor:
Daniel L. Levey, Mohamed Uduman, Antoine Tanne, Paisley T. Myers, Benjamin Morin, Jeffrey Raizer, Dennis J. Underwood, Shiwen Lin, Robert Stein, Mithun Khattar, Donald F. Hunt, Bishnu P. Joshi, Victor H. Engelhard, John C. Castle, Sandra Craig, Nicholas S. Wilson, Armen Karapetyan, Elise Drouin, Mark Findeis, Jennifer Buell, Erin D. Jeffery, John M. Goldberg, Amy Yang, Mark Cobbold
Publikováno v:
Cancer Research. 77:4609-4609
Most cancer cells carry mutations unique to the patient’s individual tumor and shared biochemical signatures that are not present in healthy cells. Agenus has three vaccine platforms designed to treat cancers based on the unique needs of a given pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f1db61bfbe24a97d166d6cc45282742
https://doi.org/10.1158/1538-7445.am2017-4609
https://doi.org/10.1158/1538-7445.am2017-4609