Protein-Functionalized Microgel for Multiple Myeloma Cells’ 3D Culture

Autor: Juan Carlos Marín-Payá, Sandra Clara-Trujillo, Lourdes Cordón, Gloria Gallego Ferrer, Amparo Sempere, José Luis Gómez Ribelles

Publikováno v: Biomedicines, Vol 10, Iss 11, p 2797 (2022)

Multiple myeloma is a hematologic neoplasm caused by an uncontrolled clonal proliferation of neoplastic plasma cells (nPCs) in the bone marrow. The development and survival of this disease is tightly related to the bone marrow environment. Proliferat

Externí odkaz: https://doaj.org/article/b71367c8981e4898a4a216e328826b46

Novel microgel culture system as semi-solid three-dimensional in vitro model for the study of multiple myeloma proliferation and drug resistance

Autor: Sandra Clara-Trujillo, Laia Tolosa, Lourdes Cordón, Amparo Sempere, Gloria Gallego Ferrer, José Luis Gómez Ribelles

Publikováno v: Biomaterials advances. 135

Multiple myeloma (MM) is a hematological malignancy in which the patient's drug resistance is one of the main clinical problems. As 2D cultures do not recapitulate the cellular microenvironment, which has a key role in drug resistance, there is an ur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b8a93b1ebc6db0469299108462a37b
https://pubmed.ncbi.nlm.nih.gov/35929221

WITHDRAWN: Computational modeling of multiple myeloma growth and tumor aggregate formation

Autor: Pau Urdeitx, Sandra Clara-Trujillo, Jose Luis Gomez Ribelles, Mohamed H. Doweidar

Publikováno v: Computer Methods and Programs in Biomedicine Update. :100073

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::559f457093e7dacaf05772177238c9c9
https://doi.org/10.1016/j.cmpbup.2022.100073

Biomimetic 3D environment based on microgels as a model for the generation of drug resistance in multiple myeloma

Autor: Luis Amaro Martins, Gloria Gallego Ferrer, Blanca Díaz-Benito, Juan Carlos Marín-Payá, José Luis Gómez Ribelles, Senentxu Lanceros-Méndez, Lourdes Cordón, Amparo Sempere, Sandra Clara Trujillo

Publikováno v: RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Materials (Basel, Switzerland)
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Materials; Volume 14; Issue 23; Pages: 7121
Materials, Vol 14, Iss 7121, p 7121 (2021)
Materials

[EN] The development of three-dimensional environments to mimic the in vivo cellular response is a problem in the building of disease models. This study aimed to synthesize and validate three-dimensional support for culturing monoclonal plasma cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89faaf405f8a55b69970cf2e903bd95

In Vitro Modeling of Non-Solid Tumors: How Far Can Tissue Engineering Go?

Autor: Gloria Gallego Ferrer, José Luis Gómez Ribelles, Sandra Clara-Trujillo

Publikováno v: RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname
International Journal of Molecular Sciences, Vol 21, Iss 5747, p 5747 (2020)
International Journal of Molecular Sciences

[EN] In hematological malignancies, leukemias or myelomas, malignant cells present bone marrow (BM) homing, in which the niche contributes to tumor development and drug resistance. BM architecture, cellular and molecular composition and interactions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117c52c414748f4b80b809482a259291
http://hdl.handle.net/10251/169419