Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sandra Chocron"'
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
TrxR2 overexpression in mice enhances metabolism and prevents high-fat diet induced metabolic deficits in mice through alteration in function of several enzymes in the tricarboxylic acid cycle and complexes of the electron transport chain.
Externí odkaz:
https://doaj.org/article/b14f713e241845ca819bb151140f98b3
Autor:
Harper S. Kim, John Son, Donghwan Lee, Joy Tsai, Danny Wang, E. Sandra Chocron, Seongwoo Jeong, Pamela Kittrell, Charles F. Murchison, Richard E. Kennedy, Alejandro Tobon, Carlayne E. Jackson, Andrew M. Pickering
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-19 (2022)
Abstract Background Prior studies on the role of gut-microbiome in Amyotrophic Lateral Sclerosis (ALS) pathogenesis have yielded conflicting results. We hypothesized that gut- and oral-microbiome may differentially impact two clinically-distinct ALS
Externí odkaz:
https://doaj.org/article/60dbb1c4887c44839d8512a58bdef49b
Akademický článek
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Publikováno v:
Physiology. 38
Obesity is characterized by an increase in adipose mass and is the leading risk factor for type 2 diabetes. Recent research suggests that activation of brown or beige fat and white adipose tissue browning represent a new therapeutic strategy for meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fec2044b10a4ddb948cf8c86d1db81b2
https://doi.org/10.1152/physiol.2023.38.s1.5734213
https://doi.org/10.1152/physiol.2023.38.s1.5734213
Autor:
E. Sandra Chocron, Erin Munkácsy, Harper S. Kim, Przemyslaw Karpowicz, Nisi Jiang, Candice E. Van Skike, Nicholas DeRosa, Andy Q. Banh, Juan P. Palavicini, Paweł Wityk, Leszek Kalinowski, Veronica Galvan, Pawel A. Osmulski, Elzbieta Jankowska, Maria Gaczynska, Andrew M. Pickering
Publikováno v:
Science Advances. 8
The proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d0c249675ddb11b594b4f2b710fb99
https://doi.org/10.1126/sciadv.abk2252
https://doi.org/10.1126/sciadv.abk2252
Autor:
Laura Quintanilla, Christi M. Gendron, Scott D. Pletcher, E. Sandra Chocron, Andrew M. Pickering, Erin Munkácsy
Publikováno v:
Aging Cell
Cognitive function declines with age throughout the animal kingdom, and increasing evidence shows that disruption of the proteasome system contributes to this deterioration. The proteasome has important roles in multiple aspects of the nervous system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c2d008afa0eb8c91972698a74a5a83
https://doi.org/10.1111/acel.13005
https://doi.org/10.1111/acel.13005
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1865(2)
The mitochondrial genome (mtDNA) represents a tiny fraction of the whole genome, comprising just 16.6 kilobases encoding 37 genes involved in oxidative phosphorylation and the mitochondrial translation machinery. Despite its small size, much interest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6798c153325fbd3827837321ab23ce3e
https://pubmed.ncbi.nlm.nih.gov/30419337
https://pubmed.ncbi.nlm.nih.gov/30419337
Autor:
Andrew M. Pickering, E. Sandra Chocron
Publikováno v:
Innovation in Aging
Mitochondrial Thioredoxin Reductase (TrxR2) is a rate limiting enzyme in the mitochondrial thioredoxin system which serves as one of the major mitochondrial ROS scavenging pathways. Txnrd2 is also a repressor of the ASK-1 oxidative stress induced apo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092b143d63bde2e8d1615242458507c9
http://europepmc.org/articles/PMC6840544
http://europepmc.org/articles/PMC6840544
Autor:
Ian J. Holt, Sara García-Gómez, Silvana Mouron, Christopher A. Powell, E. Sandra Chocron, Gloria Terrados, Luis Blanco, Juan Méndez, Aurelio Reyes, Eduardo Salido, María I. Martínez-Jiménez
Publikováno v:
Molecular Cell
Summary We describe a second primase in human cells, PrimPol, which has the ability to start DNA chains with deoxynucleotides unlike regular primases, which use exclusively ribonucleotides. Moreover, PrimPol is also a DNA polymerase tailored to bypas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e945e2d39ff358e2b41eb46bc586a3e3
https://pubmed.ncbi.nlm.nih.gov/24207056
https://pubmed.ncbi.nlm.nih.gov/24207056
Autor:
E. Sandra Chocron, Juan Méndez, Sara Rodriguez-Acebes, Luis Blanco, Sara García-Gómez, Silvana Mouron, María I. Martínez-Jiménez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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instname
DNA replication forks that collapse during the process of genomic duplication lead to double-strand breaks and constitute a threat to genomic stability. The risk of fork collapse is higher in the presence of replication inhibitors or after UV irradia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9056bf5389b1492a25a064b2ab47c660
http://hdl.handle.net/10261/98409
http://hdl.handle.net/10261/98409
