Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sandra C. Tseng"'
Autor:
Corinna Hintermair, Yi-Hsuan Ho, Rajesh Kumar Kar, Corey M. Nemec, Asfa Ali, Sohail Akhtar, Aseem Z. Ansari, Dirk Eick, Audrey P. Gasch, Sandra C. Tseng, Kennedy J Ringelberg, Mohammad Faiz Ahmad, Amit Kumar Singh, Kirtimaan Syal
Publikováno v:
Nature chemical biology
Nat. Chem. Biol. 15, 123–131 (2019)
Nat. Chem. Biol. 15, 123–131 (2019)
Phosphorylation of the carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) governs stage-specific interactions with different cellular machines. The CTD consists of Y1S2P3T4S5P6S7 heptad repeats, and sequential phospho
Autor:
Audrey P. Gasch, Gabriele Varani, Aseem Z. Ansari, Corinna Hintermair, Laurence Florens, Ying Zhang, Yi-Hsuan Ho, Dirk Eick, Corey M. Nemec, Sandra C. Tseng, Michael P. Washburn, Fan Yang, Joshua M. Gilmore, Martin Heidemann
Publikováno v:
Proc. Natl. Acad. Sci. U.S.A. 114, E3944-E3953 (2017)
The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) orchestrates dynamic recruitment of specific cellular machines during different stages of transcription. Signature phosphorylation patterns of Y1S2P3T4S5P6S7 hept
Autor:
Anton A. Komar, Amber A. Bentley, Ran Zichel, Vijaya L. Simhadri, Sandra C. Tseng, Alon Y. Hershko, Nobuko Hamasaki-Katagiri, Chava Kimchi-Sarfaty
Publikováno v:
Haemophilia. 20:e157-e163
Summary Coagulation factor IX (FIX) is a serine protease that plays a pivotal role in the blood coagulation cascade. FIX deficiency leads to a blood clotting disorder known as haemophilia B. FIX, synthesized as a prepro-peptide of 461 amino acids, is
During transcription initiation, the TFIIH-kinase Kin28/Cdk7 marks RNA polymerase II (Pol II) by phosphorylating the C-terminal domain (CTD) of its largest subunit. Here we describe a structure-guided chemical approach to covalently and specifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76310f0130292c6d3edaba12d2cf6f19
https://europepmc.org/articles/PMC5122673/
https://europepmc.org/articles/PMC5122673/
Autor:
Teresa M. Przytycka, Anton A. Komar, Zuben E. Sauna, Chava Kimchi-Sarfaty, Sandra C. Tseng, Vahan Grigoryan, E. Needlman, Nobuko Hamasaki-Katagiri, Raheleh Salari, Nathan C. Edwards, Vijaya L. Simhadri
Publikováno v:
Haemophilia. 18:933-940
Haemophilia B is an X-linked recessive disorder caused by deficiency of functional coagulation factor IX, which results almost exclusively from mutations in the F9 gene. We sought to determine features, which could distinguish between mutations that
Autor:
Jiayue Liu, Juan Daniel Pedraza Rodriguez, Sandra C. Tseng, Aseem Z. Ansari, Josefat Gregorio
Publikováno v:
The FASEB Journal. 29
Publikováno v:
The FASEB Journal. 28
Publikováno v:
BioMed Research International, Vol 2013 (2013)
BioMed Research International
BioMed Research International
Flow cytometry is widely used in cancer research for diagnosis, detection of minimal residual disease, as well as immune monitoring and profiling following immunotherapy. Detection of specific host proteins for diagnosis predominantly uses quantitati
Autor:
Adam Blaisdell, Richard J. Bram, Anton A. Komar, Alon Y. Hershko, Jae Won Choi, Zuben E. Sauna, Andrew Wu, Ryan C. Hunt, Sandra C. Tseng, Chava Kimchi-Sarfaty, Jordan Newell, Vijaya L. Simhadri, Klilah Hershko
Publikováno v:
The Journal of biological chemistry. 287(53)
The protease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat) cleaves multimers of von Willebrand factor, thus regulating platelet aggregation. ADAMTS13 deficiency leads to the fatal disorder thrombotic thrombocytopenic
Autor:
Sandra C. Tseng, Chava Kimchi-Sarfaty
Publikováno v:
Pharmacogenomics. 12(8)
The multidomain metalloprotease ADAMTS13 limits thrombus formation via the cleavage of large multimeric forms of von Willebrand factor. Deficiency of functional ADAMTS13 is associated with a number of disease pathologies including thrombotic thromboc