A Multiregional, Randomized Evaluation of the Lipid-Modifying Efficacy and Tolerability of Anacetrapib Added to Ongoing Statin Therapy in Patients With Hypercholesterolemia or Low High-Density Lipoprotein Cholesterol

Autor: Sukrut Shah, Ignacio Rodriguez Briones, Tanya B. Ashraf, Yale B. Mitchel, Yugang Dong, Wayne Huey-Heng Sheu, Sandra C. Tobias, Tayfun Sahin, Amy O. Johnson-Levonas, Yulia Moiseeva, P Rossi, Duk-Hyun Kang, Aditi Sapre, Christie M. Ballantyne, Ping Ye

Publikováno v: The American journal of cardiology. 120(4)

This phase 3, multiregional, randomized, double-blind, placebo-controlled study assessed the efficacy/safety profile of anacetrapib added to ongoing therapy with statin ± other lipid-modifying therapies in patients with hypercholesterolemia who were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f88f7c89349f6b460508da7c4b7b87a
https://pubmed.ncbi.nlm.nih.gov/28624096

Synthesis and Biological Evaluation of SERMs with Potent Nongenomic Estrogenic Activity

Autor: Sandra C. Tobias, Martin J. Kelly, Jian Qiu, Thomas S. Scanlan

Publikováno v: ChemMedChem. 1:565-571

We have synthesized novel SERMs that activate a rapid response in CNS neurons, but which lack the ability to bind to the nuclear estrogen receptors (ERalpha and ERbeta). These compounds are analogues of 4-hydroxytamoxifen, but unlike 4-hydroxytamoxif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7ca6c17a60f748fadbd10cd65f1a26
https://doi.org/10.1002/cmdc.200500098

3-Iodothyronamine: a novel hormone controlling the balance between glucose and lipid utilisation

Autor: Andrea E. DeBarber, Sandra C. Tobias, Martin Klingenspor, Gerhard Heldmaier, Luzie J. Braulke, David K. Grandy, Thomas S. Scanlan

Publikováno v: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 178(2)

3-Iodothyronamine is considered as a derivate of thyroid hormone as a result of enzymatic deiodination and decarboxylation. The physiological role of thyronamine (T1AM) is not known. The aim of this study was to analyze the metabolic response to T1AM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b00bce904a6de1345e4a511426e9c03
https://pubmed.ncbi.nlm.nih.gov/17912534

A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis

Autor: Oline K. Rønnekleiv, Stephanie J. Murphy, Martha A. Bosch, Thomas S. Scanlan, Martin J. Kelly, Jian Qiu, Kenneth S. Korach, Sharon M Graham, Andrée Krust, Sandra C. Tobias, Pierre Chambon

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2006, 26 (21), pp.5649-55. ⟨10.1523/JNEUROSCI.0327-06.2006⟩

Estrogens are involved in the hypothalamic control of multiple homeostatic functions including reproduction, stress responses, energy metabolism, sleep cycles, temperature regulation, and motivated behaviors. The critical role of 17β-estradiol (E2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ea0a33fe32b05f2d99ce99e9d8171c
https://hal.archives-ouvertes.fr/hal-00188116

Rapid signaling of estrogen in hypothalamic neurons involves a novel G-protein-coupled estrogen receptor that activates protein kinase C

Autor: David K. Grandy, Jian Qiu, Martin J. Kelly, Sandra C. Tobias, Thomas S. Scanlan, Oline K. Rønnekleiv, Martha A. Bosch

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(29)

Classically, 17β-estradiol (E2) is thought to control homeostatic functions such as reproduction, stress responses, feeding, sleep cycles, temperature regulation, and motivated behaviors through transcriptional events. Although it is increasingly ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b66a3535a81f8060f0fb39459dd0aa
https://pubmed.ncbi.nlm.nih.gov/14573532