Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sandra C. O'Buckley"'
Autor:
Clementine Adeyemi, Katie Kanter, Andrea G. Nackley, Jiegen Chen, Sandra C. O’Buckley, Yaomin Wang, Seungtae Kim, Xin Zhang
Publikováno v:
Pain. 161:446-458
Low levels of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, and stress, which potentiates catecholamine release from sympathetic nerves, are fundamental to chronic functional pain syndromes and comorbid depression, w
Autor:
Folabomi A Oladosu, Matthew S Conrad, Sandra C O'Buckley, Naim U Rashid, Gary D Slade, Andrea G Nackley
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135711 (2015)
BackgroundA subset of the population receiving opioids for the treatment of acute and chronic clinical pain develops a paradoxical increase in pain sensitivity known as opioid-induced hyperalgesia. Given that opioid analgesics are one of few treatmen
Externí odkaz:
https://doaj.org/article/7e580d06c0b743ec90d9782e2cab2d25
Autor:
Andrey V. Bortsov, Xin Zhang, Jane E. Hartung, Seungtae Kim, Julia Kozlowski, Andrea G. Nackley, Sandra C. O’Buckley
Publikováno v:
Brain, Behavior, and Immunity. 73:520-532
Functional pain syndromes, such as fibromyalgia and temporomandibular disorder, are associated with enhanced catecholamine tone and decreased levels of catechol-O-methyltransferase (COMT; an enzyme that metabolizes catecholamines). Consistent with cl
Autor:
James M. Harrington, Leah M. Johnson, Ginger Denison Rothrock, Sarah D. Shepherd, Andrea G. Nackley, Laura G. Haines, Sandra C. O’Buckley
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
A moldable and biodegradable dental material was designed for customized placement and sustained delivery of bupivacaine (BP) within an extraction cavity. Microparticles comprising poly(lactic-co-glycolic acid) (PLGA) containing BP were generated via
Autor:
Xin, Zhang, Jane E, Hartung, Andrey V, Bortsov, Seungtae, Kim, Sandra C, O'Buckley, Julia, Kozlowski, Andrea G, Nackley
Publikováno v:
Brain, behavior, and immunity. 73
Functional pain syndromes, such as fibromyalgia and temporomandibular disorder, are associated with enhanced catecholamine tone and decreased levels of catechol-O-methyltransferase (COMT; an enzyme that metabolizes catecholamines). Consistent with cl
Publikováno v:
The Journal of Pain. 19:1384.e1-1384.e14
Patients with chronic overlapping pain conditions have decreased levels of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines. Consistent with clinical syndromes, we previously demonstrated that COMT inhibition in rodents
Catheter systems that permit targeted delivery of genes, molecules, ligands, and other agents represent an investigative tool critical to the development of clinically relevant animal models that facilitate the study of neurological health and diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cccd561dd0a1434fbed9a8df6982eec
Publikováno v:
The Journal of Pain. 19:S101
Reduced catechol-O-methyltransferase (COMT) activity resulting from genetic variation or pharmacological depletion results in enhanced pain perception in humans and nociceptive behaviors in animals. Using phasic mechanical and thermal reflex tests (e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f79610b32132336e1566c825ac99ef0
https://europepmc.org/articles/PMC4359658/
https://europepmc.org/articles/PMC4359658/
Autor:
Inna E. Tchivileva, Olivia Eskew, Sandra C. O’Buckley, Folabomi A. Oladosu, Andrea G. Nackley, Terrence Wong, Jane E. Hartung
Nuclear factor-kappa B (NF-κB) is a ubiquitously expressed protein complex regulating the transcription of genes involved in inflammation and pain. Increased NF-κB activity in immune and nervous system cells is linked to several chronic pain condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c080df45f423654b98ac9d9abf7a036