Výsledky vyhledávání - "Sandra Beyer"

Akademický článek

The Role of Hypoxia-Inducible Factor 1 Alpha in Acute-on-Chronic Liver Failure

Autor: Marcus M. Mücke, Nihad El Bali, Katharina M. Schwarzkopf, Frank Erhard Uschner, Nico Kraus, Larissa Eberle, Victoria Therese Mücke, Julia Bein, Sandra Beyer, Peter J. Wild, Robert Schierwagen, Sabine Klein, Stefan Zeuzem, Christoph Welsch, Jonel Trebicka, Angela Brieger

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 3, p 1542 (2024)

Acute-on-chronic liver failure (ACLF) is associated with increased mortality. Specific therapy options are limited. Hypoxia-inducible factor 1 alpha (HIF-1α) has been linked to the pathogenesis of chronic liver disease (CLD), but the role of HIF-1α

Externí odkaz: https://doaj.org/article/1d587200b84a4bc888e33a8ee8bc764d

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Akademický článek

Renal Mesangial Cells Isolated from Sphingosine Kinase 2 Transgenic Mice Show Reduced Proliferation and are More Sensitive to Stress-Induced Apoptosis

Autor: Sandra Beyer, Stephanie Schwalm, Josef Pfeilschifter, Andrea Huwiler

Publikováno v: Cellular Physiology and Biochemistry, Vol 47, Iss 6, Pp 2522-2533 (2018)

Background/Aims: Sphingosine 1-phosphate (S1P) is considered as a key molecule regulating various cell functions including cell growth and death. It is produced by two sphingosine kinases (SK) denoted as SK-1 and SK-2. Whereas SK-1 has been extensive

Externí odkaz: https://doaj.org/article/fff45a5ff0c2466ab6e07b5e1ea2ceb1

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Akademický článek

Sorafenib Treatment and Modulation of the Sphingolipid Pathway Affect Proliferation and Viability of Hepatocellular Carcinoma In Vitro

Autor: Katja Jakobi, Sandra Beyer, Alexander Koch, Dominique Thomas, Stephanie Schwalm, Stefan Zeuzem, Josef Pfeilschifter, Georgios Grammatikos

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 7, p 2409 (2020)

Hepatocellular carcinoma (HCC) shows a remarkable heterogeneity and is recognized as a chemoresistant tumor with dismal prognosis. In previous studies, we observed significant alterations in the serum sphingolipids of patients with HCC. This study ai

Externí odkaz: https://doaj.org/article/2a054cf024464b1ab102bbf0b89bafab

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