Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Sandra Bak-Mueller"'
1
Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice
Autor: Reynold Homan, Sandra Bak Mueller, Mark D. Rekhter, Wendy Rosebury, Jeffrey C. Hanselman, Andrew Robertson, Sotirios K. Karathanasis, Tae-Sik Park, Erick Kindt, Robert L. Panek
Publikováno v: Atherosclerosis. 189:264-272
Plasma sphingomyelin (SM) has been suggested as a risk factor for coronary heart disease independent of cholesterol levels. A decrease of SM in lipoproteins is known to improve the activities of lecithin:cholesterol acyltransferase (LCAT) and lipopro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316d8ddef5d8037d78172db2489f93b2
https://doi.org/10.1016/j.atherosclerosis.2005.12.029
Zobrazit plný text záznamu
2
The combined effect of inhibiting both ACAT and HMG-CoA reductase may directly induce atherosclerotic lesion regression
Autor: Catherine Dagle, Wendy Rosebury, Sandra Bak Mueller, Bruce Auerbach, Xiaokang Lu, Thomas M.A. Bocan, D.Robert Sliskovic, B.R. Krause
Publikováno v: Atherosclerosis. 157:97-105
We hypothesized that coadministration of avasimibe and simvastatin would limit size, composition and extent of atherosclerotic lesions and potentially promote lesion regression, since bioavailable ACAT inhibitors decrease monocyte-macrophage enrichme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eac91234788861a13bb284ce8063aae
https://doi.org/10.1016/s0021-9150(00)00713-9
Zobrazit plný text záznamu
3
The ACAT Inhibitor Avasimibe Reduces Macrophages and Matrix Metalloproteinase Expression in Atherosclerotic Lesions of Hypercholesterolemic Rabbits
Autor: Sandra Bak Mueller, Wendy S. Rosebury, Chetan D. Lathia, T C Major, Thomas M.A. Bocan, Helen T. Lee, Xiaokang Lu, Brian R. Krause, Catherine Dagle
Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 20:70-79
Abstract —Given the significance of cholesteryl ester (CE) accumulation in macrophage foam cell formation, we hypothesized that inhibitors of acyl-CoA:cholesterol O -acyltransferase (ACAT) would produce a histologically stable lesion by limiting ma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1b12b3e5aa23af46a0a5abf3b791b0
https://doi.org/10.1161/01.atv.20.1.70
Zobrazit plný text záznamu
4
A specific 15-lipoxygenase inhibitor limits the progression and monocyte–macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit
Autor: Wendy S. Rosebury, Alan Daugherty, Kathryn Welch, Susan L. Kuchera, Joseph A. Cornicelli, Thomas M.A. Bocan, Sandra Bak Mueller
Publikováno v: Atherosclerosis. 136:203-216
Oxidant signalling and lipoprotein oxidation may play important roles in atherosclerotic lesion development. Given coincident localization of 15-lipoxygenase (15-LO), stereospecific products of 15-LO and epitopes of modified LDL in atherosclerotic le
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69facd305582c50b53aad4b697ed2d17
https://doi.org/10.1016/s0021-9150(97)00204-9
Zobrazit plný text záznamu
5
Tetrazole-substituted ureas as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). A novel preparation of ureas from weakly nucleophilic amines
Autor: Maureen K. Anderson, Andrew D. White, Thomas M.A. Bocan, R. F. Bousley, Claude Forsey Purchase, Sandra Bak Mueller, Brian R. Krause, Peter Lee, J. F. Reindel, Reynold Homan, R. L. Stanfield, K. L. Hamelehle, Cecilia Speyer
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:1753-1758
A novel series of tetrazole-substituted ureas 2 were prepared from weakly nucleophilic amines using a new coupling method. The ureas were found to potently inhibit liver ACAT in vitro and lower total serum cholesterol in vivo. A comparison of urea 2b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19c77c667fa12975e42e0099ca9943ab
https://doi.org/10.1016/0960-894x(96)00310-1
Zobrazit plný text záznamu
7
Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation
Autor: Mark Wallace Creswell, Edie Quenby Brown, Paul D. Uhlendorf, Sandra Bak Mueller, D.Robert Sliskovic, Thomas M.A. Bocan, Roger S. Newton, Michelle J. Mazur, Helen T. Lee, Bruce D. Roth, Patrick Michael O'brien
Publikováno v: Atherosclerosis. 111:127-142
Atherosclerotic lesion development was assessed in the thoracic aorta and chronically denuded iliac-femoral artery of hypercholesterolemic New Zealand White rabbits using inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase which h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920706ccd11732eb955bbb2a721f0736
https://doi.org/10.1016/0021-9150(94)90198-8
Zobrazit plný text záznamu
10
Atherosclerosis in Octodon degus (degu) as a model for human disease
Autor: Sandra Bak-Mueller, Stephen L. Pinkosky, Jeffrey C. Hanselman, Patrick A Lester, Heather Jensen, Christine Castle, Bruce M. Taylor, Reynold Homan, Michelle Washburn
Publikováno v: Atherosclerosis. 212(1)
Objective: Animal models of atherosclerosis are essential to elucidate disease mechanisms and develop new therapies. Each model features advantages and disadvantages in exemplifying the pathophysiology of human atherosclerosis. Diet-induced developme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5833410c047496c2114671a7f07b47
https://pubmed.ncbi.nlm.nih.gov/20638066
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje