Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Sandra Amor"'
Autor:
Erik Nutma, Nurun Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C. Marzin, Robert C. J. Muirhead, Irene Falk, Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper Anink, David Story, Siddharthan Chandran, Jiabin Tang, Maria C. Trolese, Takashi Saito, Takaomi C. Saido, Katharine H. Wiltshire, Paula Beltran-Lobo, Alexandra Phillips, Jack Antel, Luke Healy, Marie-France Dorion, Dylan A. Galloway, Rochelle Y. Benoit, Quentin Amossé, Kelly Ceyzériat, Aurélien M. Badina, Enikö Kövari, Caterina Bendotti, Eleonora Aronica, Carola I. Radulescu, Jia Hui Wong, Anna M. Barron, Amy M. Smith, Samuel J. Barnes, David W. Hampton, Paul van der Valk, Steven Jacobson, Owain W. Howell, David Baker, Markus Kipp, Hannes Kaddatz, Benjamin B. Tournier, Philippe Millet, Paul M. Matthews, Craig S. Moore, Sandra Amor, David R. Owen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quanti
Externí odkaz:
https://doaj.org/article/6e4226618e024c669f4f230499a8801b
Autor:
Anneke Miedema, Emma Gerrits, Nieske Brouwer, Qiong Jiang, Laura Kracht, Michel Meijer, Erik Nutma, Regina Peferoen-Baert, Anna T. E. Pijnacker, Evelyn M. Wesseling, Marion H. C. Wijering, Hans-Joachim Gabius, Sandra Amor, Bart J. L. Eggen, Susanne M. Kooistra
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Multiple sclerosis (MS) is a disease of the central nervous system that is characterized by inflammation and focal areas of demyelination, ultimately resulting in axonal degradation and neuronal loss. Several lines of evidence point towards
Externí odkaz:
https://doaj.org/article/e6a6235939ee4b9089024f9f8ef305b6
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1969 (2023)
The occurrence of B cell aggregates within the central nervous system (CNS) has prompted the investigation of the potential sources of pathogenic B cell and T cell responses in a subgroup of secondary progressive multiple sclerosis (MS) patients. Nev
Externí odkaz:
https://doaj.org/article/61a69c74158a4efe99551eda64c3cc4c
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
There has been a growing interest in the presence and role of B cell aggregates within the central nervous system of multiple sclerosis patients. However, very little is known about the expression profile of molecules associated with these aggregates
Externí odkaz:
https://doaj.org/article/7974cc2a5c3747ad8c3e68a7e39814ff
Autor:
Sabela Rodríguez-Lorenzo, Julia Konings, Susanne van der Pol, Alwin Kamermans, Sandra Amor, Jack van Horssen, Maarten E. Witte, Gijs Kooij, Helga E. de Vries
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract The choroid plexus (CP) is strategically located between the peripheral blood and the cerebrospinal fluid, and is involved in the regulation of central nervous system (CNS) homeostasis. In multiple sclerosis (MS), demyelination and inflammat
Externí odkaz:
https://doaj.org/article/8c7ddcfe2bec45a086daa724750ab49d
Autor:
Ella A. Zuiderwijk-Sick, Céline van der Putten, Raissa Timmerman, Jennifer Veth, Erica M. Pasini, Linda van Straalen, Paul van der Valk, Sandra Amor, Jeffrey J. Bajramovic
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Interleukin (IL)-4 is a cytokine that affects both adaptive and innate immune responses. In the central nervous system, microglia express IL-4 receptors and it has been described that IL-4-exposed microglia acquire anti-inflammatory properties. We he
Externí odkaz:
https://doaj.org/article/000ca16e7f24436986f08d1b1ba48e40
Publikováno v:
BMJ Neurology Open, Vol 3, Iss 2 (2021)
Background and objective The concentration of neurofilament light (NfL) protein in cerebrospinal fluid (CSF) and blood is widely considered as a quantitative measure of neuro-axonal injury. Immune reactivity to NfL released into extracellular fluids
Externí odkaz:
https://doaj.org/article/cdd6a9370b6d48f7aaa21e0d359882c0
Autor:
Jiangshan Zhan, Florian Nepomuk Fegg, Hannes Kaddatz, Sebastian Rühling, Julia Frenz, Bernd Denecke, Sandra Amor, Peter Ponsaerts, Tanja Hochstrasser, Markus Kipp
Publikováno v:
Neurobiology of Disease, Vol 155, Iss , Pp 105371- (2021)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) with episodes of inflammatory demyelination and remyelination. While remyelination has been linked with functional recovery in MS patients, there is evidenc
Externí odkaz:
https://doaj.org/article/d0c5a8f42ac54b1498bcc32084c4d86c
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 8, Pp 1362-1372 (2019)
Abstract Objective Despite progress in treating relapsing multiple sclerosis (MS), effective inhibition of nonrelapsing progressive MS is an urgent, unmet, clinical need. Animal models of MS, such as experimental autoimmune encephalomyelitis (EAE), p
Externí odkaz:
https://doaj.org/article/c433fd89108b4b11a8e6fffbe7672209
Autor:
David W. Hampton, Sandra Amor, David Story, Megan Torvell, Malika Bsibsi, Johannes M. van Noort, Siddarthan Chandran
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Progressive neuronal death during tauopathies is associated with aggregation of modified, truncated or mutant forms of tau protein. Such aggregates are neurotoxic, promote spreading of tau aggregation, and trigger release of pro-inflammatory factors
Externí odkaz:
https://doaj.org/article/2aa29171a7c64b26aa76954d35b5498e