Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sandra Aedo"'
Publikováno v:
Antimicrob Agents Chemother
Nitrofurantoin (NIT) is a broad-spectrum bactericidal antibiotic used in the treatment of urinary tract infections. It is a pro-drug that once activated by nitroreductases goes on to inhibit bacterial DNA, RNA, cell wall, and protein synthesis. Previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66180200047576121f072293632e5184
https://doi.org/10.1128/aac.00858-20
https://doi.org/10.1128/aac.00858-20
Publikováno v:
BMC Microbiology
BMC Microbiology, Vol 19, Iss 1, Pp 1-12 (2019)
BMC Microbiology, Vol 19, Iss 1, Pp 1-12 (2019)
Background Persisters are rare phenotypic variants within a bacterial population that are capable of tolerating lethal antibiotic concentrations. Passage through stationary phase is associated with the formation of persisters (type I), and a major ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc43993282d5d30eee66cb96e384f94a
http://europepmc.org/articles/PMC6591824
http://europepmc.org/articles/PMC6591824
Publikováno v:
Methods in Molecular Biology ISBN: 9781493991419
The Keio single gene knockout collection comprises approximately 4000 mutants of E. coli K12 strain BW25113, where each mutant contains a kanamycin resistance cassette in place of a single nonessential gene. This mutant library has proven to be incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0842bef7a21a29f45146a794ef55a9be
https://doi.org/10.1007/978-1-4939-9142-6_9
https://doi.org/10.1007/978-1-4939-9142-6_9
Autor:
Sandra Aedo, Alexander Tomasz
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:2311-2317
Resistance to beta-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) requires the presence of an acquired genetic determinant, mecA or mecC , which encode penicillin-binding protein PBP2A or PBP2A′, respectively. Although all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68616199056f755fe0a14842d9b7652b
https://doi.org/10.1128/aac.02697-15
https://doi.org/10.1128/aac.02697-15
Autor:
Marilyn Chung, Som S. Chatterjee, Eun Ju Choo, Li Basuino, Anatoly Severin, Natalie C. J. Strynadka, J. Andrew N. Alexander, Thaina Miranda da Costa, Stephanie M. Hamilton, Henry F. Chambers, Alexander Tomasz, Sandra Aedo
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Penicillin-binding protein 4 (PBP4), a nonessential, low-molecular-weight penicillin-binding protein of Staphylococcus aureus , has been implicated in low-level resistance to β-lactam antibiotics, although the mechanism is unknown. Mutations in PBP4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f114cc632243a91dab56631429917d3f
https://doi.org/10.1128/aac.02727-16
https://doi.org/10.1128/aac.02727-16
Publikováno v:
Microbial Ecology. 68:324-328
Marine bacteria from aquaculture areas with industrial use of quinolones have the potential to pass quinolone resistance genes to animal and human pathogens. The VPA0095 gene, related to the quinolone resistance determinant qnrA, from clinical isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f4ebfcc35990f343f7c593ef0abf80
https://doi.org/10.1007/s00248-014-0409-2
https://doi.org/10.1007/s00248-014-0409-2
Autor:
Yuk-Ching Tse-Dinh, Sandra Aedo
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:5116-5119
Quinolones trap the covalent gyrase-DNA complex in Escherichia coli , leading to cell death. Processing activities for trapped covalent complex have not been characterized. A mutant strain lacking SbcCD nuclease activity was examined for both accumul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc553919e5a3cf96677197a788abc54f
https://doi.org/10.1128/aac.00130-13
https://doi.org/10.1128/aac.00130-13
Autor:
Sandra Aedo, Yuk-Ching Tse-Dinh
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:5458-5464
DNA topoisomerases are important targets in anticancer and antibacterial therapy because drugs can initiate cell death by stabilizing the transient covalent topoisomerase-DNA complex. In this study, we employed a method that uses CsCl density gradien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af676ddd892b277172fc30f372184c5
https://doi.org/10.1128/aac.01182-12
https://doi.org/10.1128/aac.01182-12
Publikováno v:
Nature Microbiology. 2:1584-1585
The incorporation of additional gene circuits into hosts can often lead to unpredicted and undesirable behaviours. Recent work has developed a modelling framework that accounts for host–circuit interactions and can predict a variety of phenotypes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5c3ed537555d4c1f8b72f69e4cd830
https://doi.org/10.1038/s41564-017-0058-6
https://doi.org/10.1038/s41564-017-0058-6
Autor:
Gagandeep Narula, Elena P. Sorokin, Thirunavukkarasu Annamalai, Bokun Cheng, Agnes Wong, Yuk-Ching Tse-Dinh, Sandra Aedo
Publikováno v:
Journal of Biological Chemistry. 286:18673-18680
The strictly conserved arginine residue proximal to the active site tyrosine of type IA topoisomerases is required for the relaxation of supercoiled DNA and was hypothesized to be required for positioning of the scissile phosphate for DNA cleavage to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f1447545e6e7855fe4831abb5c73b9
https://doi.org/10.1074/jbc.m111.229450
https://doi.org/10.1074/jbc.m111.229450