Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sandra A. Dando"'
Autor:
Lisa Zadjura, Ivette Medina, Rita L. Civiello, Eugene V. Genovesi, Celia D’Arienzo, Sandra A. Dando, H. Belgin Gulgeze, Anthony M. Marino, Keith D. Combrink, X. Alan Wang, Richard J. Colonno, Christopher Cianci, Nicholas A. Meanwell, Kuo-Long Yu, Richard A. Dalterio, Mark Krystal, Lucinda Lamb, Zheng Yang, J. J. Kim Wright, Kathleen F. Kadow, Brian Lee Venables, Junius Clarke, Zhufang Li, Ny Sin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:895-901
A series of benzimidazole-based inhibitors of respiratory syncytial virus (RSV) fusion were optimized for antiviral potency, membrane permeability and metabolic stability in human liver microsomes. 1-Cyclopropyl-1,3-dihydro-3-[[1-(4-hydroxybutyl)-1H-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f0b15de4e6b963a15896b9c356593f
https://doi.org/10.1016/j.bmcl.2006.11.063
https://doi.org/10.1016/j.bmcl.2006.11.063
Autor:
Richard A. Morrison, William J. Irwin, Saeho Chong, Peter A. Lambert, Peter Timmins, Vanessa A. Moore, Sandra A. Dando
Publikováno v:
International Journal of Pharmaceutics. 210:29-44
Purpose: To assess the affinities of a series of ACE inhibitors for the di/tri/oligopeptide transport system (DTS) using a rapid in vitro system. Methods: Monolayers of Caco-2 cells were cultured in plastic wells for 7–9 days and the uptake of Gly-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445ffd273472c10816f6c5cdc86230be
https://doi.org/10.1016/s0378-5173(00)00564-0
https://doi.org/10.1016/s0378-5173(00)00564-0
Autor:
Bethanne M. Warrack, Anthony M. Marino, Gerald C. DiDonato, Sandra A. Dando, Saeho Chong, Anne Starrett-Arroyo, Ronald E. White, Mary T. Obermeier, Denis E. Ryono, Richard A. Morrison
Publikováno v:
Journal of Pharmaceutical Sciences. 85:828-833
The oral bioavailability of BMS-183920, a diacidic, potent angiotensin II receptor antagonist, is low in rats (approximately 11%). In vivo studies in bile duct-cannulated rats indicated that BMS-183920 was metabolically stable and that the low bioava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910061b6378eca06de011201f17be086
https://doi.org/10.1021/js9600282
https://doi.org/10.1021/js9600282
Autor:
Anthony M. Marino, Saeho Chong, Sandra A. Dando, Richard Morrison, Amrita Kamath, Neil Mathias
Publikováno v:
Archives of pharmacal research. 30(8)
Permeability estimates using Caco-2 cells do not accurately predict the absorption of hydrophilic drugs that are primarily absorbed via the paracellular pathway. The objective of this study was to investigate whether modulation of tight junctions wou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4052c7ad01de1d89e20e6ebf3b0678f
https://pubmed.ncbi.nlm.nih.gov/17879754
https://pubmed.ncbi.nlm.nih.gov/17879754
Publikováno v:
Pharmaceutical Research. 14:1835-1837
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8117692375e49efcbc6d3c7d4042d4ef
https://doi.org/10.1023/a:1012112820371
https://doi.org/10.1023/a:1012112820371
Autor:
William J. Irwin, Sandra A. Dando, Saeho Chong, Richard A. Morrison, Peter Timmins, Vanessa A. Moore
Publikováno v:
International journal of pharmaceutics. 210(1-2)
Purpose: To establish an in vitro system for the rapid assessment of the affinities of potential substrates for the di/tri/oligopeptide transport system (DTS). Methods: Monolayers of Caco-2 cells were cultured in plastic wells for 7–9 days and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3193b7ad7c880cae9843feabbbec9ce7
https://pubmed.ncbi.nlm.nih.gov/11163984
https://pubmed.ncbi.nlm.nih.gov/11163984
Autor:
M. S. Bathala, K.J. Kripalani, Anthony M. Marino, Saeho Chong, Richard A. Morrison, Sandra A. Dando
Publikováno v:
Journal of pharmaceutical sciences. 85(3)
Peptidic drugs such as β -lactam aminocephalosporin antibiotics (e.g., cephalexin) and the ACE inhibitors lisinopril, quinapril, and benzazepril are apparently absorbed, at least in part, by the intestinal dipeptide transporter system (DTS). Althoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9623a2c198db046f25085295c37dfb98
https://pubmed.ncbi.nlm.nih.gov/8699329
https://pubmed.ncbi.nlm.nih.gov/8699329
Autor:
J. J. Kim Wright, Keith D. Combrink, H. Belgin Gulgeze, Eugene V. Genovesi, Sandra A. Dando, Richard A. Dalterio, Celia D’Arienzo, Brian Lee Venables, Junius Clarke, Lisa Zadjura, Kuo-Long Yu, Lucinda Lamb, Christopher Cianci, Mark Krystal, Ivette Medina, Richard J. Colonno, Ny Sin, Zhufang Li, Rita L. Civiello, Anthony M. Marino, Nicholas A. Meanwell, Kathleen F. Kadow, Zheng Yang, X. Alan Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2385
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3631113fb5fdc2be16660ebf488560e
https://doi.org/10.1016/j.bmcl.2007.03.020
https://doi.org/10.1016/j.bmcl.2007.03.020